Hemodynamic Monitoring of the Contralateral Testis during Unilateral Testicular Torsion Describes the Mechanism of Damage

Salman, Ahmet Bedii; Mutlu, Sevgi; Ab, Iskit; Mo, Guc; Mutlu, Mehmet Fırat; Fc, Tanyel

doi:10.1159/000019659

Cited by 25 publications

(13 citation statements)

References 24 publications

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“…Different theories have been put forward to explain contralateral testicular damage. The proposed theories include reflex decrease in contralateral testicular blood flow [4, 5, 6, 7, 8, 9], autoimmunity [10, 11], associated congenital anomalies [12, 13]and subclinical torsion attacks of the contralateral testis [14]. Since spermatic cord torsion even in the absence of testis and epididymis is shown to cause contralateral testicular injury and contralateral testicular injury has been demonstrated by DNA flow cytometry within 24 h of ipsilateral testicular torsion [15], autoimmunity, associated congenital anomalies and subclinical torsion attacks of the contralateral testis seem unlikely.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin in Albino Rats Prevents Contralateral Testis from the Damaging Effects Posed by Ipsilateral Testis That Underwent Torsion

Sarioğlu

Gedikoğlu²,

Bingöl-Koloğlu

et al. 2001

Eur Urol

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Section: Introductionmentioning

confidence: 99%

Capsaicin in Albino Rats Prevents Contralateral Testis from the Damaging Effects Posed by Ipsilateral Testis That Underwent Torsion

Sarioğlu

Gedikoğlu²,

Bingöl-Koloğlu

et al. 2001

Eur Urol

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“…It allows measurement of microvascular perfusion continuously and precisely. With these properties, it is superior to other modalities such as microsphere or isotope method because these methods cannot measure continuous blood flow [22,23].…”

Section: Discussionmentioning

confidence: 99%

Rosuvastatin protects tissue perfusion in the experimental testicular torsion model

et al. 2009

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Recently, anti-inflammatory and tissue protective effects of statins have been shown independent from its anti-hyperlipidemic effect. It has been shown that one of the statins, rosuvastatin, may reduce ischemia/reperfusion (I/R)-induced tissue injury in the brain, intestines, and heart. We planned an experimental study to evaluate the effect of rosuvastatin on I/R injury encountered after the detorsion of the testicular torsion. Rats were divided into three groups. In group 1, testis basal blood flow (basal value) was measured with LASER Doppler flowmeter (LDF). Testis was relocated into the scrotum without torsion. Two and 3 h after the basal measurement, testis was brought out from the same incision, and the second (second value) and third (third value) testicular blood flow measurements were done, respectively. In group 2, after the measurement of basal value testicular torsion was created. Second and third value measurements were obtained with LDF at the end of the 2 h of testicular torsion just before the detorsion and 1 h after detorsion. In group 3, same procedures in torsion/detorsion group were repeated in this group, but 10 mg/kg rosuvastatin was injected intraperitoneally 30 min before detorsion. Second values in groups 2 and 3 were significantly lower than group 1. Third values were significantly low in group 2 compared to groups 1 and 3. Regarding the third measurement, there was no significant difference between the groups 1 and 3. Tissue injury is closely related with condition of microvascular perfusion after I/R. Rosuvastatin can protect tissue perfusion in the experimental testicular torsion model.

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“…ROI, regions of interest; TIC, timeintensity curve. et al [4] suggested that, following unilateral testicular torsion, the blood flow in the contralateral testis slowed through the mediation of body fluids, causing ischemia, hypoxia, and the subsequent pathological changes stated above. However, differing from earlier reports, Figure 4.…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal, biochemical, immunological, histopathological, and vasculogenic studies have been performed, but the results are still controversial. Different mechanisms have been proposed for this phenomenon, including ischemia, hypoxia [4], and activation of oxygen-free radicals caused by reperfusion [5].…”

Section: Introductionmentioning

confidence: 99%

TRPM8 and prostate cancer: to overexpress or repress, that is the question—comment on “Effects of TRPM8 on proliferation and motility of prostate cancer PC-3 cells” by Yang ZH et al. in Asian Journal of Andrology

Kulkarni¹

2009

Asian J Androl

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The changes of blood perfusion of contralateral testis after unilateral testicular torsion remain controversial. In this study, 28 New Zealand white male rabbits were randomly divided into five groups. Group A (n = 8), the control group, underwent a sham operation on the unilateral testis without inducing testicular torsion. In groups B, C, and D (n = 5 each), unilateral testicular torsion was induced, and, after 3, 6 or 24 h, respectively, detorsion was performed. In group E (n = 5), permanent unilateral testicular torsion was applied. Contrast-enhanced ultrasound was used to observe the blood perfusion of the contralateral testis at the following stages: pre-torsion (preopration), immediately post-torsion (postopration), pre-detorsion, immediately post-detorsion, and late-stage post-detorsion (6-12 h post-detorsion in groups B-D) or at a similar time point (15-21 h post-torsion in group E). Time-intensity curves were generated, and the following parameters were derived and analyzed: arrival time, time to peak intensity, peak intensity, and half-time of the descending peak intensity. The analysis revealed that blood perfusion of the contralateral testis increased immediately after testicular torsion on the opposite side (P < 0.05), which increased with prolonged testicular torsion of the other testis. This research demonstrated that contrast-enhanced ultrasound was valuable in evaluating blood perfusion of the contralateral testis after unilateral testicular torsion.

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Hemodynamic Monitoring of the Contralateral Testis during Unilateral Testicular Torsion Describes the Mechanism of Damage

Cited by 25 publications

References 24 publications

Capsaicin in Albino Rats Prevents Contralateral Testis from the Damaging Effects Posed by Ipsilateral Testis That Underwent Torsion

Capsaicin in Albino Rats Prevents Contralateral Testis from the Damaging Effects Posed by Ipsilateral Testis That Underwent Torsion

Rosuvastatin protects tissue perfusion in the experimental testicular torsion model

TRPM8 and prostate cancer: to overexpress or repress, that is the question—comment on “Effects of TRPM8 on proliferation and motility of prostate cancer PC-3 cells” by Yang ZH et al. in Asian Journal of Andrology

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