Hemodynamic changes in pregnancy

Comparison of subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia

“…28 In addition, gestational age should be considered in studies of pregnant women because systemic and ocular changes persist until the end of the pregnancy. [28][29][30][31] In this study and Takahashi et al, the target subjects were limited to the last trimester, whereas Sayin et al included subjects in both the second and third trimesters, which may have caused the difference. Moreover, as mentioned previously, endothelial cell dysfunction and hyperpermeability are major causes of multi-organ failure in pre-eclampsia.…”

Alterations in maternal and fetal heart functions accompany failed spiral arterial remodeling in pregnant mice

“…16 Early in normal human and mouse pregnancies, mean arterial blood pressure decreases slightly or is stable. 17,18 This indicates that gains in uterine flow are more attributable to morphological remodeling of uterine arteries than to alterations in their smooth muscle tone. 19 Mouse models have promoted understanding of mechanisms regulating gestational changes to the cardiovascular system.…”

Correlação entre cálcio e insulina durante o teste de tolerância à glicose em ovelhas gestantes e não gestantes

“…Esta ação da insulina pode ter relevância clínica na ocorrência de hipocalcemia e hipomagnesemia em ruminantes alimentados com alto nível de energia no pré-parto, já que o grau de adiposidade neste período está associado a maiores concentrações séricas de insulina, aumentando a resistência a este hormônio nos tecidos periféricos (Beever, 2006;Kerestes et al, 2009;Roche et al, 2009). Tal fato, somado à maior taxa de filtração glomerular na gestante (Baylis, 1994;Thornburg et al, 2000), poderia predispor à hipocalcemia e à hipomagnesemia, pela perda destes minerais via filtração renal (Defronzo et al, 1976). Figura 1.…”