Hemodynamic arterial changes in heart failure: a proposed new paradigm of "heart and vessels failure"

Galati, Giuseppe; Germanova, Olga; Iozzo, Renato V.; Buraschi, Simone; Shchukin, Y.; Germanov, Andrey; Germanov, Vladimir; Терешина, О.В.; Senni, Michele; Margonato, Alberto

doi:10.23736/s2724-5683.21.05786-0

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…Galati et al have shown an active compensatory vascular role, a reduction in all measured vascular kinetic parameters, consistently across patients with three groups of heart failure (heart failure with reduced ejection fraction [HFrEF], heart failure with moderately reduced ejection fraction and heart failure with preserved ejection fraction [HFpEF]), establishing the clear interplay of the heart and its tributary peripheral vessels. [ 24 ]…”

Section: Alcoholic Dilated Cardiomyopathymentioning

confidence: 99%

Alcohol and Heart Failure

Rasoul,

Ajay,

Abdullah

et al. 2023

Eur Cardiol

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Alcohol is the most frequently consumed toxic substance in the world and remains a major global public health issue, with one in three adults consuming it worldwide. Alcohol use is a leading risk factor for disease, contributing to over 60 acute and chronic health conditions, with a particularly complex association with cardiovascular disease. Chronic excessive alcohol consumption is associated with a range of cardiac complications, including decreased myocardial contractility, hypertension, arrhythmias, MI and heart failure. However, low-level alcohol consumption is believed to have a protective effect against ischaemic heart disease and diabetes. In most cohort studies, small to moderate amounts of alcohol consumption have not been linked to heart failure, indicating a threshold effect of alcohol with individual (possibly genetic) predisposition rather than a continuous effect of exposure. This review article explores the potential benefits of alcohol on the heart, the association between alcohol use and alcoholic cardiomyopathy and the epidemiology, clinical correlates and management of alcoholic cardiomyopathy.

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Section: Alcoholic Dilated Cardiomyopathymentioning

confidence: 99%

Alcohol and Heart Failure

Rasoul,

Ajay,

Abdullah

et al. 2023

Eur Cardiol

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“…New drugs, such as vericiguat specifically act on arterial function and can be more beneficial in specific populations with a more compromised arterial function -such as older women with HF and HFpEF patients. 71…”

Section: New Molecules With Impact On Quality Of Life In Hfref Verici...mentioning

confidence: 99%

Women and Diabetes: Preventing Heart Disease in a New Era of Therapies

et al. 2021

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Despite major advances in cardiovascular research over the past decade, women with type 2 diabetes have a high risk of cardiovascular events. Several factors contribute to the poor prognosis for women, including higher levels of frailty and comorbidities, but their cardiovascular risk is underestimated and there is suboptimal implementation and uptitration of new evidence-based therapies, leading to high morbidity and mortality. Recent studies highlight the need for better management of diabetes in women that can be pursued and achieved in light of recent results from randomised controlled trials demonstrating evidence of the benefits of new therapeutic strategies in improving cardiovascular outcomes and quality of life of women covering the entire cardiovascular continuum. This review critically discusses the multiple benefits for women of new pharmacological treatments, such as glucagon-like peptide-1 receptor agonists, sodium–glucose cotransporter type 2 inhibitors (SGLT2i), proprotein convertase subtilisin/kexin type 9 inhibitors, inclisiran, icosapent ethyl and bempedoic acid in preventing cardiovascular events, and treatments, such as angiotensin receptor neprilysin inhibitors, SGLT2i, vericiguat and omecamtiv mecarbil, for preventing heart failure.

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“…Moreover, the phenotyping should include also the vessels' function, and in particular that of arteries that currently are considered as mere bystanders (or “passive tubes”), whereas they cover an important and poorly studied role. 11 …”

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confidence: 99%

LV Strain Superiority Over LVEF in HFmrEF

Galati,

Germanova,

Pedretti

2023

JACC: Advances

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Hemodynamic arterial changes in heart failure: a proposed new paradigm of "heart and vessels failure"

Cited by 8 publications

References 29 publications

Alcohol and Heart Failure

Alcohol and Heart Failure

Women and Diabetes: Preventing Heart Disease in a New Era of Therapies

LV Strain Superiority Over LVEF in HFmrEF

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