Hemispheric asymmetry and aging: right hemisphere decline or asymmetry reduction

Dolcos, Florin; Rice, Heather J.; Cabeza, Roberto

doi:10.1016/s0149-7634(02)00068-4

Cited by 397 publications

(274 citation statements)

References 61 publications

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“…The observation of consistent lateral bias in representational tasks like mental number line and tactile bisection are especially problematic under the HAROLD model with its focus on decreasing hemispheric asymmetry over age especially in prefrontal cortex, given the role Running Head: ADULT DEVELOPMENTAL TRAJECTORIES 26 prefrontal cortex is known to play in spatial memory (Courtney et al, 1998). For similar reasons, our findings are not in line with the right hemi-ageing model (Dolcos et al, 2002;Prodan et al, 2007) nor with findings indicating rightward biases for older adults (Benwell et al, 2014b).…”

contrasting

confidence: 76%

“…The extent to which this attenuation of pseudoneglect should occur is also likely to reflect the degree of of prefrontal Running Head: ADULT DEVELOPMENTAL TRAJECTORIES 6 involvement -hence tasks that have a high level cognitive component such as representational tasks are likely to be more affected than more perceptual tasks that are likely to be processed by more posterior brain regions. One alternative to HAROLD is the right hemi-ageing model of cognitive ageing which posits that the right hemisphere ages in a different way to the left hemisphere (for discussion see Dolcos, Rice & Cabeza, 2002;Prodan, Orbelo & Ross, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Adult developmental trajectories of pseudoneglect in the tactile, visual and auditory modalities and the influence of starting position and stimulus length

Brooks

Darling

Malvaso

et al. 2016

Brain and Cognition

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Pseudoneglect is a tendency to pay more attention to the left side of space, typically demonstrated on tasks like visuo-spatial line bisection, tactile rod bisection and the mental representation of numbers. The developmental trajectory of this bias on these three tasks is not fully understood. In the current study younger participants aged between 18 and 40 years of age and older participants aged between 55 and 90 years conducted three spatial tasks: 1) visuospatial line bisection -participants were asked to bisect visually presented lines of different lengths at the perceived midpoint; 2) touch-driven tactile rod bisection in the absence of vision -participants were asked to feel the length of a wooden rod with their index finger and bisect the rod at the perceived centre; and 3) mental number line bisection in the absence of vision -participants were asked to listen to a pair of numbers and respond with the numerical midpoint between the pair. The results showed that both younger and older participants demonstrated pseudoneglect (leftward biases) in the visual, tactile and mental number line tasks and that the magnitude of pseudoneglect for each group was influenced by physical or mentally represented starting side (start left versus start right) and stimulus length. We provide an exploration of pseudoneglect in younger and older adults in different tasks that vary in the degree to which mental representations are accessed and argue that pseudoneglect is a result of a right hemisphere attentional orienting process that is retained throughout adulthood. Our results indicate that, contrary to some current models of cognitive ageing, asymmetrical patterns of hemispheric activity may occur in older age.

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contrasting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Adult developmental trajectories of pseudoneglect in the tactile, visual and auditory modalities and the influence of starting position and stimulus length

Brooks

Darling

Malvaso

et al. 2016

Brain and Cognition

View full text Add to dashboard Cite

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“…If our attenuated hemispheric asymmetry in older as compared to younger adults results from compensatory or de-differentiation mechanisms (e.g. Dolcos, Rice, & Cabeza, 2002;Hommet et al, 2008), we would expect the respective brain correlates to be found in callosal structures or their connectivities (Regard et al, 1994), because it is likely to be within these structures that dynamic changes in hemispheric asymmetry occur (e.g. Bachtold et al, 2001;Cherry et al, 2005;Hausmann & Gunturkun, 2000;e.g.…”

Section: Resultsmentioning

confidence: 98%

Performance of younger and older adults in lateralised right and left hemisphere asymmetry tasks supports the HAROLD model

Collins

Möhr

2013

Laterality: Asymmetries of Body, Brain and Cognition

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“…Similarly, the aging literature demonstrated reduced laterality in hemisphere-specific findings indicating more equally distributed representation of memory with age (see Doleos et al, 2002 for review). These findings were based upon task-elicited signal change and generally did not focus on synchrony in the signal generated between regions of interest (ROI).…”

Section: A Model For Hyperconnectivitymentioning

confidence: 90%

Hyperconnectivity is a fundamental response to neurological disruption.

et al. 2015

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Objective: In the cognitive and clinical neurosciences, the past decade has been marked by dramatic growth in a literature examining brain "connectivity" using noninvasive methods. We offer a critical review of the blood oxygen level dependent functional MRI (BOLD fMRI) literature examining neural connectivity changes in neurological disorders with focus on brain injury and dementia. The goal is to demonstrate that there are identifiable shifts in local and large-scale network connectivity that can be predicted by the degree of pathology. We anticipate that the most common network response to neurological insult is hyperconnectivity but that this response depends upon demand and resource availability. Method: To examine this hypothesis, we initially reviewed the results from 1,426 studies examining functional brain connectivity in individuals diagnosed with multiple sclerosis, traumatic brain injury, mild cognitive impairment, and Alzheimer's disease. Based upon inclusionary criteria, 126 studies were included for detailed analysis. Results: Results from 126 studies examining local and whole brain connectivity demonstrated increased connectivity in traumatic brain injury and multiple sclerosis. This finding is juxtaposed with findings in mild cognitive impairment and Alzheimer's disease where there is a shift to diminished connectivity as degeneration progresses. Conclusion: This summary of the functional imaging literature using fMRI methods reveals that hyperconnectivity is a common response to neurological disruption and that it may be differentially observable across brain regions. We discuss the factors contributing to both hyper-and hypoconnectivity results after neurological disruption and the implications these findings have for network plasticity.

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Hemispheric asymmetry and aging: right hemisphere decline or asymmetry reduction

Cited by 397 publications

References 61 publications

Adult developmental trajectories of pseudoneglect in the tactile, visual and auditory modalities and the influence of starting position and stimulus length

Adult developmental trajectories of pseudoneglect in the tactile, visual and auditory modalities and the influence of starting position and stimulus length

Performance of younger and older adults in lateralised right and left hemisphere asymmetry tasks supports the HAROLD model

Hyperconnectivity is a fundamental response to neurological disruption.

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