Hemihypertrophy and a poorly differentiated embryonal rhabdomyosarcoma of the pelvis

Samuel, David; Tsokos, Maria; DeBaun, Michael R.

doi:10.1002/(sici)1096-911x(199901)32:1<38::aid-mpo8>3.0.co;2-h

Cited by 19 publications

(2 citation statements)

References 25 publications

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“…Owing to the early age of onset, in utero exposures have been suggested to have a role in its aetiology, including in utero X-ray exposure (Grufferman, 1991(Grufferman, , 2009, maternal drug use (Grufferman et al, 1993(Grufferman et al, , 1982, advanced maternal age (Grufferman, 1991) and stillbirths (Ghali et al, 1992). In addition, several familial syndromes (Diller et al, 1995;DeBaun and Tucker, 1998;Samuel et al, 1999;Tekin et al, 2002;Meyer et al, 2004;Aoki et al, 2005;Gripp, 2005;Ferrari et al, 2007;Moschovi et al, 2007;Trahair et al, 2007;Li and Fraumeni, 1969a, b) and a larger prevalence of congenital malformations (Ruymann et al, 1988) among affected children suggest that genetic predisposition may be important. However, collectively these factors account for only a small fraction of cases.…”

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confidence: 99%

Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype

et al. 2009

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BACKGROUND: Little is known about risk factors for childhood rhabdomyosarcoma (RMS) and the histology-specific details are rare. METHODS: Case -control studies formed by linking cancer and birth registries of California, Minnesota, New York, Texas and Washington, which included 583 RMS cases (363 embryonal and 85 alveolar RMS) and 57 966 randomly selected control subjects, were analysed using logistic regression. The associations of RMS (overall, and based on embryonal or alveolar histology) with birth weight across five 500 g categories (from 2000 to 4500 g) were examined using normal birth weight (2500 -3999 g) as a reference. Large (490th percentile) and small (o10th percentile) size for gestational age were calculated based on birth weight distributions in controls and were similarly examined. RESULTS: High birth weight increased the risk of embryonal RMS and RMS overall. Each 500 g increase in birth weight increased the risk of embryonal RMS (odds ratio (OR) ¼ 1.27, 95% confidence interval (CI) ¼ 1.14 -1.42) and RMS overall (OR ¼ 1.18, 95% CI ¼ 1.09 -1.29). Large size for gestational age also significantly increased the risk of embryonal RMS (OR ¼ 1.42, 95% CI ¼ 1.03 -1.96). CONCLUSIONS: These data suggest a positive association between accelerated in utero growth and embryonal RMS, but not alveolar RMS. These results warrant cautious interpretation owing to the small number of alveolar RMS cases.

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confidence: 99%

Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype

et al. 2009

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“…Thus, evaluation of the malignant grade of hepatoblastoma is necessary to improve the outcome of patients with advanced hepatoblastoma. Several molecular markers have been analysed to identify hepatoblastomas with high malignant potential: loss of heterozygosity (LOH) of chromosome 11p15.5, which is often affected in nephroblastoma and rhabdomyosarcoma in children, may contain a putative tumour suppressor gene for hepatoblastoma (Albrecht et al, 1994), but is unlikely to be a prognostic marker (Samuel et al, 1999;von Schweinitz et al, 2002). The mutation or deletion of the b-catenin gene exon 3 is frequently detected in hepatoblastoma, suggesting overactivation of the wingless/WNT signal pathway (Koch et al, 1999).…”

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High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma

et al. 2004

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Risk of tumorigenesis in overgrowth syndromes: A comprehensive review

Lapunzina

2005

American J of Med Genetics Pt C

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215

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Overgrowth syndromes (OGS) comprise a heterogeneous group of disorders in which the main characteristic is that either weight, height, or head circumference is 2-3 standard deviations (SD) above the mean for sex and age. A striking feature of OGS is the risk of neoplasms. Here, the relative frequency of specific tumors in each OGS, topographic location, and age of appearance is determined by reviewing published cases. In some OGS (Perlman, Beckwith-Wiedemann, and Simpson-Golabi-Behmel syndromes and hemihyperplasia) more than 94% of tumors appeared in the abdomen usually before 10 years of age, mainly embryonal in type. In Perlman syndrome, only Wilms tumor has been recorded, whereas in Sotos syndrome, lympho-hematologic tumors are most frequent. Based on literature review, a specific schedule protocol for tumor screening is suggested for each OGS. A schedule with different intervals and specific tests is proposed for a more rational cost/benefit program for these disorders.

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Hemihypertrophy and a poorly differentiated embryonal rhabdomyosarcoma of the pelvis

Cited by 19 publications

References 25 publications

Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype

Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype

High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma

Risk of tumorigenesis in overgrowth syndromes: A comprehensive review

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