2018
DOI: 10.18632/aging.101506 View full text |Buy / Rent full text
|
|

Abstract: Aim: Premature senescence of vascular endothelial cells is a leading cause of various cardiovascular diseases. Therapies targeting endothelial senescence would have important clinical implications. The present study was aimed to evaluate the potential of heme oxygenase-1 (HO-1) as a therapeutic target for endothelial senescence.Methods and Results: Upregulation of HO-1 by Hemin or adenovirus infection reversed H2O2-induced senescence in human umbilical vein endothelial cells (HUVECs); whereas depletion of HO-1… Show more

Help me understand this report

Search citation statements

Order By: Relevance
0
0
0
0
0
0
21
0

Publication Types

Select...

Relationship

0
0

Authors

Journals