Hematopoietic Stem Cell Transplantation: An Overview of Infection Risks and Epidemiology

Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

“…4,5 Donor lymphocyte infusion may control infections and, to a limited extent, leukemia/lymphoma relapse, but the associated graft-versus-host disease (GVHD) significantly limits the clinical success of this procedure. [6][7][8][9][10] We and others have previously demonstrated that life-threatening viral infections with pathogens such as Epstein-Barr virus (EBV), cytomegalovirus (CMV), and adenoviruses (AdV) occurring after allogeneic HSCT can be treated without toxicity (including GVHD) by infusing ex vivo-expanded, donorderived, virus-specific cytotoxic T cells (VSTs).…”

Antifungal prophylaxis in stem cell transplantation centers in Turkey

“…The use of F led to a decrease in the number of Candida infections, which was subsequently followed by an increase in the number of Aspergillus infections [1]. The main problem was that F has no effect on Aspergillus and Aspergillus infection is associated with a very high mortality rate in SCT patients [1,2,[7][8][9]. The need for an antifungal drug with a wider spectrum of effect led to the use of I prophylaxis in SCT, with some success; however, bioavailability and tolerability issues precluded its use as a primary agent for prophylaxis in SCT [10][11][12].…”

Invasive Fungal Infections in Patients with Acute Leukemia and Hematopoietic Stem Cell Transplant Recipients

“…account for the majority of mold fungal infections, primarily mold pneumonias. Zygomycetes are indentified in 10% to 20% of mold pneumonias, Scedosporium spp., Fusarium spp., and other molds are responsible for a very small percent of cases [16]. In the case of invasive Aspergillosis (IA), when infection spreads beyond the respiratory tract, patients often develop signs of systemic inflammation and multiorgan failure.…”

“…Paronychia is often caused by bacteria or yeasts; however, in severely immunocompromised recipients it can be caused by Fusarium spp. or other molds and lead to life-threatening IFI [16].…”

Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host disease after allogeneic stem cell transplantation

“…[4][5][6] However, allo-HSCT is associated with major complications, such as severe acute graft-versus-host disease (aGvHD) and infections. [7][8][9] Differential diagnosis of aGvHD from treatment-related toxicities can be difficult and is mainly made according to clinical symptoms and biopsies. Thus, a method is urgently needed to diagnose early onset of aGvHD and to identify patients at risk of developing severe GvHD in an observerindependent, unbiased fashion.…”