Hematology and blood biochemistry in wild hybrid marmosets from the Atlantic Forest, Brazil

Silva, Ita de Oliveira e; Silva, Fernanda de Fátima Rodrigues da; Fuzessy, Lisieux Franco; Tavela, Alexandre de Oliveira; Júnior, Moacir Carretta; Silva, Vinícius Herold Dornelas e; Paula, Tarcízio Antônio Rêgo de; Boere, Vanner

doi:10.1590/0103-8478cr20120822

Cited by 14 publications

(23 citation statements)

References 10 publications

(7 reference statements)

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“…However, in the case of A pigra , higher levels were found in the females . The MCHC levels obtained were similar to those previously described for several other primate species . However, compared with the cited examples, this is the only case where levels in females were significantly higher than in males, which enhances the differences between the sexes in A guariba clamitans .…”

Section: Discussionsupporting

confidence: 87%

Hematological and serum biochemistry data on southern brown howler monkeys (Alouatta guariba clamitans) in captivity in Brazil

Gonçalves

Souza

Pitz

et al. 2019

J of Medical Primatology

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Background: Physiological values reflect the health condition and responses of individuals to handling in captivity. The aim of this study was to establish hematological and serum biochemistry parameters of clinically healthy animals of the Alouatta guariba clamitans subspecies. Methods:We collected blood samples from adult males and females kept at the Center for Biological Research of Indaial after chemical containment with 3.9 mg/kg of tiletamine hydrochloride and zolazepam.Results: Significant differences between males and females were found in the levels of erythrocytes, hemoglobin, hematocrit, lymphocytes, neutrophils, platelets, mean corpuscular hemoglobin concentration (MCHC), and gamma-glutamyltranspeptidase (GGT). Conclusions: Our results suggest the existence of sexual dimorphism in some physiological parameters of A guariba clamitans. The parameters reported herein can be used as reference values for other populations kept under similar conditions. K E Y W O R D S Alouatta guariba clamitans, blood biochemistry, electrophoresis, hematology, neotropical primates, reference values, serum proteinogram How to cite this article: Gonçalves GHP, de Souza Junior JC, Pitz HS, Peruchi AR, Branco FS, Hirano ZMB. Hematological and serum biochemistry data on southern brown howler monkeys (Alouatta guariba clamitans) in captivity in Brazil. J Med Primatol. 2019;48:313-319. https ://doi.

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Section: Discussionsupporting

confidence: 87%

Hematological and serum biochemistry data on southern brown howler monkeys (Alouatta guariba clamitans) in captivity in Brazil

Gonçalves

Souza

Pitz

et al. 2019

J of Medical Primatology

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“…geoffroyi (data not shown). Our findings are different from those described for other species of marmosets 1016 . Low erythrocytes counts and low hemoglobin concentrations are related to anemia, but the young marmosets of this study seem healthy.…”

Section: Discussioncontrasting

confidence: 99%

“…Complete blood count and blood chemistry values are important tools as a means of assessing animal health status. Hematological values and blood chemistry studies of free‐ranging marmosets in a natural environment are still scarce 9,10 . Considering the health risks to the marmosets, humans, and wildlife, the objective of this study was to describe the hematological and blood chemistry values of free‐ranging C .…”

Section: Introductionmentioning

confidence: 99%

Hematology and blood chemistry reference values of free‐ranging Callithrix geoffroyi in Urban environment in Espírito Santo state, Brazil

Gariglio

Boere

Malukiewicz

et al. 2021

J of Medical Primatology

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Background The Callithrix geoffroyi are increasingly present in Brazilian urban areas, where they are vulnerable to health problems. The purpose of this study was a description of hematology and nine blood chemistry parameters of free‐ranging C. geoffroyi. Methods Thirty individuals were captured in urban‐forested settings. The marmosets were anesthetized, venopunctioned, and released shortly after recovery. The analysis was carried on in a veterinary laboratory, using automatic cells counter, staining methods, and an automatic biochemical analyzer. Results and Conclusions Male and female free‐ranging C. geoffroyi have similar hematological and blood chemistry values. The adults presented higher concentrations of erythrocytes (P <.02) and hemoglobin (P <.02) than young marmosets. The platelet concentration was lower (P <.05) in adults comparing to young marmosets. There were not statistically significant differences between young and adult blood chemistry concentrations. This is the first time that are presented hematology and blood biochemistry data on free‐ranging C. geoffroyi.

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“…However, there have also been numerous reports of sex-specific phenotypes including behavior (Yamamoto, Domeniconi, & Box, 2004), endocrine beyond the basic sex hormones (de Sousa, Galvao, Sales, de Castro, & Galvao-Coelho, 2015), and even at the molecular level in terms of gene expression differences (Reinius et al, 2008). Hematological differences have been reported between male and female marmosets though in relatively young animals (Silva et al, 2014). It is of note that our animals originated from at least two sources (UTHSA and SNPRC) but were housed within our animal facility for a period of at least 2 months prior to sampling.…”

Section: Discussionmentioning

confidence: 99%

Long‐term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle‐aged marmosets

Sills

Artavia

DeRosa

et al. 2018

American J Primatol

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Interventions to extend lifespan and improve health with increasing age would have significant impact on a growing aged population. There are now several pharmaceutical interventions that extend lifespan in laboratory rodent models with rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR) being the most well studied. In this study, we report on the hematological effects on a cohort of middle-aged common marmosets (Callithrix jacchus) that were enrolled in a study to test the effects of daily rapamycin treatment on aging in this species. In addition, we assessed whether sex was a significant factor in either baseline assessment or as an interaction with rapamycin treatment. Among our cohort at baseline, we found few differences in either basic morphology or hematological markers of blood cell counts, metabolism or inflammation between male and female marmosets. After dosing with rapamycin, surprisingly we found trough blood concentrations of rapamycin were significantly lower in female compared to male marmosets. Despite this pharmacological difference, both sexes had only minor changes in cellular blood counts after 9 months of rapamycin. These data then suggest that the potential clinical hematological side effects of rapamycin are not likely outcomes of long-term rapamycin in relatively healthy, middle-aged marmosets.

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Hematology and blood biochemistry in wild hybrid marmosets from the Atlantic Forest, Brazil

Abstract: This paper aims to describe the hematological and biochemical values of wild hybrid marmoset (Callithrix penicillata and C. geoffroyi) found in a forest zone of Southeastern Brazil.The marmosets were anaesthetized using ketamine and xylazine hydrochloride. Blood samples (0.5-1mL)

Cited by 14 publications

References 10 publications

Hematological and serum biochemistry data on southern brown howler monkeys (Alouatta guariba clamitans) in captivity in Brazil

Hematological and serum biochemistry data on southern brown howler monkeys (Alouatta guariba clamitans) in captivity in Brazil

Hematology and blood chemistry reference values of free‐ranging Callithrix geoffroyi in Urban environment in Espírito Santo state, Brazil

Long‐term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle‐aged marmosets

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