Hematological Abnormalities in COVID-19: A Narrative Review

Rahman, Asma; Niloofa, Roshan; Jayarajah, Umesh; Mel, Sanjay de; Abeysuriya, V.; Seneviratne, Suranjith L.

doi:10.4269/ajtmh.20-1536

Cited by 78 publications

(70 citation statements)

References 136 publications

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“…A temporal trend of lowering PLT counts in COVID-19 patients could indicate a worsening thrombotic state [ 87 , 88 , 89 , 90 ]. It was reported that a PTL count <200 × 10 9 /L at admission was related to a threefold higher mortality rate [ 91 ]. On the other hand, improvement of thrombocytopenia in COVID-19 patients can indicate clinical progress [ 91 ].…”

Section: Plateletsmentioning

confidence: 99%

“…It was reported that a PTL count <200 × 10 9 /L at admission was related to a threefold higher mortality rate [ 91 ]. On the other hand, improvement of thrombocytopenia in COVID-19 patients can indicate clinical progress [ 91 ]. It was also reported that patients with severe COVID-19 displayed a higher degree of PTs activation, PLT–monocyte aggregation, and PLT–lymphocyte ratio (PLR) [ 88 , 92 , 93 , 94 ].…”

Section: Plateletsmentioning

confidence: 99%

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Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling

Salamanna

Maglio

Sartori

et al. 2021

IJMS

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Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy and vitamin D also involves platelets (PLTs), since vitamin D deficiency stimulates PLT activation and aggregation and increases fibrinolysis and thrombosis. Vitamin D and PLTs share and play specific roles not only in coagulation and thrombosis but also during inflammation, endothelial dysfunction, and immune response. Additionally, another ‘fil rouge’ between vitamin D and PLTs is represented by their role in mineral metabolism and bone health, since vitamin D deficiency, low PLT count, and altered PLT-related parameters are linked to abnormal bone remodeling in certain pathological conditions, such as osteoporosis (OP). Hence, it is possible to speculate that severe COVID-19 patients are characterized by the presence of several predisposing factors to bone fragility and OP that may be monitored to avoid potential complications. Here, we hypothesize different pervasive actions of vitamin D and PLT association in COVID-19, also allowing for potential preliminary information on bone health status during COVID-19 infection.

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Section: Plateletsmentioning

confidence: 99%

Section: Plateletsmentioning

confidence: 99%

Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling

Salamanna

Maglio

Sartori

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…The most common hematological findings in patients with COVID-19 include reduced lymphocyte count, while the platelet count differs according to the severity of the disease as well as the total number of the white blood cell count [ 7 , 8 , 9 ]. Severe lymphopenia was linked to more severe disease compared to milder lymphopenia, although leukocytosis was referred as an indication of severe inflammation process [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms

et al. 2021

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Since the beginning of the COVID-19 pandemic, there have been numerous reports and reviews on the complications caused by the disease, analyzing the acute and chronic consequences. The main symptoms of SARS-CoV-2 are dry cough, fever, and fatigue. COVID-19 appears to affect all systems, including renal, cardiovascular, circulatory, and respiratory systems, causing chronic obstructive pulmonary disease. We report on a 14-year-old male adolescent, who presented with thrombocytopenia (platelet count 92 × 109 /L) and leukopenia (white blood count 4.2 × 103 /μL) that was observed two months ago. Ten days before the first blood test, a viral infection with nasal congestion and runny nose was reported, without other accompanying symptoms. Viral antibodies screening revealed positivity for all the three specific COVID-19 antibodies. Further haematological evaluation with bone marrow aspiration revealed non-specific dysplastic features of the red cell and megakaryocyte progenitors. Although haematological alterations due to COVID-19 infection are available from adult patients’ reports, the effect of COVID-19 infection in the pediatric population is underestimated and this is the first case with such haematological involvement. Noteworthy, in the current case, the impact of the COVID-19 infection was not related to the severity of the disease, as the symptoms were mild. In similar cases, bone marrow aspiration would not be performed as a part of routine work-up. Thus, it is important when evaluating pediatric patients with COVID-19 infection to search and report those alterations in order to better understand the impact and the spectrum of clinical manifestations of the specific viral infection in children and adolescents.

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“…Despite being commonly associated with hypercoagulability, COVID-19 is also associated with thrombocytopenia [12]. Therefore, a full blood count is mandated before providing neuraxial anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

Anaesthetic implications during the COVID-19 pandemic: an appraisal of the literature

et al. 2021

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The coronavirus disease-2019 (COVID-19) pandemic has raised many concerns regarding the safety of patients and healthcare workers. Anaesthetic implications and the impact of this pandemic on anaesthesiologists have been discussed widely in the recent past. Operating theatres are high-risk areas where anaesthesiologists perform various aerosolgenerating procedures (AGPs).Prolong patient contact predisposes them to the risk of exposure. Scarcity of resources and limitations in testing pose an additional risk to the anesthesiologist. Although guidance from various professional bodies is in abundance, there is a general lack of consensus. This review summarises current evidence and guidelines related to anaesthesiology during the COVID-19 pandemic. Ensuring the provision of unhindered care, ensuring patient safety and protecting oneself with optimum utilization of available resources remain a challenge to the anesthesiologist.

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Hematological Abnormalities in COVID-19: A Narrative Review

Cited by 78 publications

References 136 publications

Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling

Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling

A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms

Anaesthetic implications during the COVID-19 pandemic: an appraisal of the literature

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