Hematocrit of mammals (Artiodactyla, Carnivora, Primates) at 1500 m and 2100 m altitudes

Mortola, Jacopo P.; Wilfong, DeeAnn

doi:10.1016/j.zool.2017.07.001

Cited by 8 publications

(3 citation statements)

References 71 publications

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“…For a suitable systemic ozone evaluation, differences between animal and human blood composition have to be taken into consideration. It is also important to notice that the human hematological and biochemical range are different when compared with the animals, which also diverges according to the gender, age, species, breed, and the altitude that those animals are ( Miglio et al., 2020 ; Mortola and Wilfong, 2017 ; Scholkmann et al., 2019 ; Wintrobe and Shumacker, 1936 ). For example, while in dogs, the hematocrit references value are between 37-55% in dogs, 24-45% in cats, 32-48% in horses and 41-54% in humans; the blood cell distribution in M/mm³ is 5-8,5 in dogs, 5-10 in cats, 6-12,9 in horses and 4,3-6 in humans ( Klaassen, 1999 ; Soares et al., 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Ozone and its derivatives in veterinary medicine: A careful appraisal

Orlandin

Machado

Ambrósio

et al. 2021

Veterinary and Animal Science

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Highlights In the Vet field, there are lot of scientific publications with missing or incomplete data, poor case reports and papers without a control group or unrepresentative sample. Differences between animal and human blood composition, anatomy and physiology must be taken into consideration, especially in therapies not yet fully approved. Some practitioners produce their own ozonated solution or autohemotherapy, in the absence of information regarding the compatibility of the material used. Other than the properties of the commercial preparations, the standardization of both treatment methods and times influence the results obtained with ozone therapy.

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Section: Discussionmentioning

confidence: 99%

Ozone and its derivatives in veterinary medicine: A careful appraisal

Orlandin

Machado

Ambrósio

et al. 2021

Veterinary and Animal Science

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“…Although the effect of elevation on the change in Hct is a relatively well-studied phenomenon in some mammals including humans (e.g. Mortola & Wilfong 2017), rodents (apart from laboratory rats and mice) are rather overlooked in this context. Thus, Hct has been sufficiently studied only in a few rodents from different elevations in the South-American Andes (various species - Morrison et al 1963a, b), the Rocky Mountains in North America (the North American deer mouse Peromyscus maniculatus -e.g.…”

Section: The Effect Of Elevation On Haematocrit In Ethiopian Rodentsmentioning

confidence: 99%

The effect of elevation on haematocrit in Ethiopian rodents

Lövy

Lavrenchenko

Kostin

et al. 2020

Journal of Vertebrate Biology

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“…The structure and composition of gut microbiota in NHPs are closely related to factors, such as dietary composition 28,29 , habitat occupancy 30 , social interactions 30 , eco-environmental factors 31 , and health status 32,33 . The mechanisms of high-altitude adaptation in NHPs, including physiological, behavioral, and genetic, have been widely studied [34][35][36] . However, less is known about the role of gut microbiota in high-altitude adaptation.…”

Section: Introductionmentioning

confidence: 99%

Metagenome and metabolome insights into the energy compensation and exogenous toxin degradation of gut microbiota in high-altitude rhesus macaques (Macaca mulatta)

Zhao

Yao

et al. 2023

npj Biofilms Microbiomes

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There have been many reports on the genetic mechanism in rhesus macaques (RMs) for environmental adaptation to high altitudes, but the synergistic involvement of gut microbiota in this adaptation remains unclear. Here we performed fecal metagenomic and metabolomic studies on samples from high- and low-altitude populations to assess the synergistic role of gut microbiota in the adaptation of RMs to high-altitude environments. Microbiota taxonomic annotation yielded 7471 microbiota species. There were 37 bacterial species whose abundance was significantly enriched in the high-altitude populations, 16 of which were previously reported to be related to the host’s dietary digestion and energy metabolism. Further functional gene enrichment found a stronger potential for gut microbiota to synthesize energy substrate acetyl-CoA using CO2 and energy substrate pyruvate using oxaloacetate, as well as a stronger potential to transform acetyl-CoA to energy substrate acetate in high-altitude populations. Interestingly, there were no apparent differences between low-altitude and high-altitude populations in terms of genes enriched in the main pathways by which the microbiota consumed the three energy substrates, and none of the three energy substrates were detected in the fecal metabolites. These results strongly suggest that gut microbiota plays an important energy compensatory role that helps RMs to adapt to high-altitude environments. Further functional enrichment after metabolite source analysis indicated the abundance of metabolites related to the degradation of exogenous toxins was also significantly higher in high-altitude populations, which suggested a contributory role of gut microbiota to the degradation of exogenous toxins in wild RMs adapted to high-altitude environments.

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Hematocrit of mammals (Artiodactyla, Carnivora, Primates) at 1500 m and 2100 m altitudes

Cited by 8 publications

References 71 publications

Ozone and its derivatives in veterinary medicine: A careful appraisal

Ozone and its derivatives in veterinary medicine: A careful appraisal

The effect of elevation on haematocrit in Ethiopian rodents

Metagenome and metabolome insights into the energy compensation and exogenous toxin degradation of gut microbiota in high-altitude rhesus macaques (Macaca mulatta)

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