Hemarthrosis in hemophilic mice results in alterations in M1-M2 monocyte/macrophage polarization

Nieuwenhuizen, Laurens; Schutgens, Roger E. G.; Coeleveld, K.; Mastbergen, S.C.; Roosendaal, G.; Biesma, Douwe H.; Lafeber, Floris P. J. G.

doi:10.1016/j.thromres.2013.10.039

Cited by 32 publications

(26 citation statements)

References 34 publications

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“…Decrement in M2 and induction of M1 macrophage polarization after induction was observed in the red pulp of spleen, and the M1 monocytes sharply decreased on the first day of induction, followed by gradual recovery afterwards. Polarization of synovial macrophages and joint lavage into M1/M2 state were in a similar trend at the affected knee, but no significant effect was noted for the unaffected knee, as expected, which reached to the top on the first day and returned to the normal state within seven days [48]. Levels and changes of each polarized monocyte and macrophage were found to be distinct in circulating blood, spleen and synovial fluid after occurrence of hemarthrosis.…”

Section: Role Of Macrophages In Joint Diseases and Hemodynamic Dissupporting

confidence: 53%

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Koh

Yang

Lai

et al. 2018

IJMS

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Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokines and chemokines from macrophages can lead to the modification of the microenvironment for bridging innate and adaptive immune responses. Increasing evidence suggests that polarized macrophages are pivotal for disease progression, and the regulation of macrophage polarization may provide a new approach in therapeutic treatment of inflammation-related diseases, including cancer, obesity and metabolic diseases, fibrosis in organs, brain damage and neuron injuries, and colorectal disease. Polarized macrophages affect the microenvironment by secreting cytokines and chemokines while cytokines or mediators that are produced by resident cells or tissues may also influence macrophages behavior. The interplay of macrophages and other cells can affect disease progression, and therefore, understanding the activation of macrophages and the interaction between polarized macrophages and disease progression is imperative prior to taking therapeutic or preventive actions. Manipulation of macrophages can be an entry point for disease improvement, but the mechanism and potential must be understood. In this review, some advanced studies regarding the role of macrophages in different diseases, potential mechanisms involved, and intervention of drugs or phytochemicals, which are effective on macrophage polarization, will be discussed.

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Section: Role Of Macrophages In Joint Diseases and Hemodynamic Dissupporting

confidence: 53%

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Koh

Yang

Lai

et al. 2018

IJMS

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“…In models of chronic venous leg ulcers and wound healing, macrophage iron overload correlates with a proinflammatory M1 phenotype, TNFa, and hydroxyl radical production. 58 Nieuwenhuizen et al 59 observed a decrease in M2 and an increase in M1 macrophages in the red pulp of the spleen and in synovial tissue in hemophilic mice. The authors speculated that this results from an increased number of damaged RBCs and a higher level of circulating Hb following hemarthrosis.…”

Section: Org Frommentioning

confidence: 97%

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Vinchi

Silva

Ingoglia

et al. 2016

Blood

231

247

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“…We found that acute hemarthrosis can lead to temporary changes of synovium and cartilage histology [3,5,14], but it can not cause persistent damage. The result is consistent with foreign reports [15,16].…”

Section: Discussionmentioning

confidence: 76%

Effects of hemarthrosis on cartilage and synovium in rabbits

Zhao

Chen

et al. 2016

Eur J Trauma Emerg Surg

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Hemarthrosis in hemophilic mice results in alterations in M1-M2 monocyte/macrophage polarization

Cited by 32 publications

References 34 publications

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Effects of hemarthrosis on cartilage and synovium in rabbits

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