Hemangiosarcoma in chronic leg ulcer

Malignant transformation of leg ulcers: a retrospective study of 85 cases

“…The preferred treatment is surgical excision with grafting, or irradiation if surgery is not possible. Other rare skin tumours have been reported to arise on CLUVO, such as fibrosarcomas, 17,18 malignant fibrous histiocytomas, 19,20 leiomyosarcomas 21 and angiosarcomas, [22][23][24] which were not observed in our series. As for BCC, in the absence of previous histologic examination, it is not known with certainty whether these tumours arose secondarily on the ulcer or were ab initio ulcerated sarcomas.…”

Chronic venous ulceration with associated angiosarcoma

“…Two cases of angiosarcoma involving a cutaneous ulcer were reported. 10,11 The first case report described a chronic ulcer that developed in a gumma scar which has been associated with lymphoedema for 20 years. The histopathology described in the report is not clearly stated.…”

“…The histopathology described in the report is not clearly stated. 10 On the other hand, the second reported case was a poorly differentiated angiosarcoma that developed in an ulcer that persisted for 15 years in the left lower leg. The lesion recurred following multiple radiation therapies.…”

Angiosarcoma of the Thigh with Thrombosis in the Femoral Artery

“…Lever and Schaumburg-Lever (1) classified angiosarcoma of the skin into (I) angiosarcoma occurring on the scalp and face of elderly persons, the most common form, and (II) angiosarcoma secondary to persistent chronic lymphedema, often developing several years after radical mastectomy in the edematous tissue of the ipsilateral arm and sometimes in a chronically and severely edematous extremity without a preceding tumor. In addition to these two representative types and Kaposi's sarcoma, other types of angiosarcoma have also been encountered in clinical practice (2)(3)(4)(5). We report a case of angiosarcoma on the thigh with unusual clinical and histologic characteristic features.…”