Hemangiosarcoma in chronic leg ulcer

Kofler, H.

doi:10.1001/archderm.124.7.1080

Cited by 6 publications

(4 citation statements)

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“…The preferred treatment is surgical excision with grafting, or irradiation if surgery is not possible. Other rare skin tumours have been reported to arise on CLUVO, such as fibrosarcomas, 17,18 malignant fibrous histiocytomas, 19,20 leiomyosarcomas 21 and angiosarcomas, [22][23][24] which were not observed in our series. As for BCC, in the absence of previous histologic examination, it is not known with certainty whether these tumours arose secondarily on the ulcer or were ab initio ulcerated sarcomas.…”

Section: Discussionmentioning

confidence: 54%

Malignant transformation of leg ulcers: a retrospective study of 85 cases

Combemale

Bousquet

Kanitakis

et al. 2007

Acad Dermatol Venereol

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Malignant transformation of chronic leg ulcers of vascular origin is mainly encountered in elderly patients and manifests as an abnormally vegetating lesion, which may be occasionally bilateral. Malignant transformation usually occurs towards well-differentiated SCC and only exceptionally towards BCC. The high death rate, especially in metastatic cases, is at least partly due to delay in diagnosis. Surgery remains the treatment of choice. Leg amputation should be considered in the most extensive cases.

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Section: Discussionmentioning

confidence: 54%

Malignant transformation of leg ulcers: a retrospective study of 85 cases

Combemale

Bousquet

Kanitakis

et al. 2007

Acad Dermatol Venereol

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“…Two cases of angiosarcoma involving a cutaneous ulcer were reported. 10,11 The first case report described a chronic ulcer that developed in a gumma scar which has been associated with lymphoedema for 20 years. The histopathology described in the report is not clearly stated.…”

Section: Discussionmentioning

confidence: 99%

“…The histopathology described in the report is not clearly stated. 10 On the other hand, the second reported case was a poorly differentiated angiosarcoma that developed in an ulcer that persisted for 15 years in the left lower leg. The lesion recurred following multiple radiation therapies.…”

Section: Discussionmentioning

confidence: 99%

Chronic venous ulceration with associated angiosarcoma

Alenezi

Brassard²

2009

J Dermatol Case Rep

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Background: Angiosarcoma is a malignant tumor of the blood vessels' endothelial lining. The tumor is very aggressive and tends to recur locally and metastasize to distant organs. Commonly, it is associated with different risk factors like lymphoedema, prior radiotherapy but rarely, it may also be associated with chronic venous ulceration.Main observation: We present a patient with a chronic venous ulceration who developed angiosarcoma of the ulcerated leg with good outcome after treatment.Conclusion: It is very important to follow patients with chronic wounds and recognize changes which may be life threatening. In addition to squamous cell carcinoma (Marjolin's tumor), which is most common, angiosarcoma can develop within a venous ulcer.

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“…Lever and Schaumburg-Lever (1) classified angiosarcoma of the skin into (I) angiosarcoma occurring on the scalp and face of elderly persons, the most common form, and (II) angiosarcoma secondary to persistent chronic lymphedema, often developing several years after radical mastectomy in the edematous tissue of the ipsilateral arm and sometimes in a chronically and severely edematous extremity without a preceding tumor. In addition to these two representative types and Kaposi's sarcoma, other types of angiosarcoma have also been encountered in clinical practice (2)(3)(4)(5). We report a case of angiosarcoma on the thigh with unusual clinical and histologic characteristic features.…”

Section: Introductionmentioning

confidence: 94%

Angiosarcoma of the Thigh with Thrombosis in the Femoral Artery

Miyamoto

Mihara

Iwasaki

et al. 1992

The Journal of Dermatology

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We report a case of angiosarcoma with some peculiar clinical features developing on the left thigh of a 63-year-old man. The early primary lesion was erythematous with necrotic areas. The initial biopsy specimen of the lesion indicated a benign angioproliferative process. However, the necrotic area enlarged rapidly, ulcerated with severe pain, and thus was widely excised. The excised specimen had a malignant histologic appearance, particularly in the fascia, and was diagnosed as angiosarcoma. Following local recurrence, the lesion was complicated by thrombosis of the femoral artery at the affected site. A similar cutaneous lesion subsequently arose on the right lower leg, and thrombosis developed in the right femoral artery. Both legs had to be amputated. There were no distant metastases.

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Hemangiosarcoma in chronic leg ulcer

Cited by 6 publications

References 0 publications

Malignant transformation of leg ulcers: a retrospective study of 85 cases

Malignant transformation of leg ulcers: a retrospective study of 85 cases

Chronic venous ulceration with associated angiosarcoma

Angiosarcoma of the Thigh with Thrombosis in the Femoral Artery

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