Mai N. Vu, Hannah G. Kelly, Hyon‐Xhi Tan, Jennifer A. Juno, Robyn Esterbauer, Thomas P. Davis, Nghia P. Truong, Adam K. Wheatley, Stephen J. Kent
Abstract:Despite remarkable successes of immunization in protecting public health, safe and effective vaccines against a number of life-threatening pathogens such as HIV, ebola, influenza, and SARS-CoV-2 remain urgently needed. Subunit vaccines can avoid potential toxicity associated with traditional whole virion-inactivated and live-attenuated vaccines; however, the immunogenicity of subunit vaccines is often poor. A facile method is here reported to produce lipid nanoparticle subunit vaccines that exhibit high immuno…
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