Abstract:The processes and factors that regulate B cell fate decisions during IgM memory cell development and differentiation are unknown, and may differ from those required by canonical memory cells. In our experimental model of Ehrlichia muris infection, we have characterized two long-lived B cell populations: IgM memory cells, and IgM bone marrow (BM) antibody secreting cells (ASCs). The IgM+ memory B cells are required for recall IgG responses, while the BM ASCs produce antigen-specific IgM responsible for maintain… Show more
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