HELLP sendromu

ACAR, Dilek; ÇETİNDAĞ, Elif Nazlı; ALKILIÇ, Ayşegül; Kalafat, Erkan; Aytaç, Ruşen

doi:10.17827/aktd.80953

Cited by 2 publications

(2 citation statements)

References 56 publications

(95 reference statements)

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“…When considered as an independent clinical picture, similar to preeclampsia, abnormal placentation accompanies HELLP syndrome, but unlike preeclampsia, excessive hepatic inflammation and overactivation of the coagulation system play a role in the pathogenesis. Hemolysis increases over time [ 31 ]. The problem in the coagulation system should be tackled in the first place, and if we have a predefinition of HELLP, coagulation parameters should be kept in balance to prevent quickly bleeding.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting ICU Stay and Length of Stay in the ICU in Patients with HELLP Syndrome in a Tertiary Referral Hospital

Ağaçayak

Buğday

Peker

et al. 2022

International Journal of Hypertension

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Objective. The study aimed to compare patients with HELLP syndrome who require intensive care and who do not require intensive care and evaluate the factors affecting the length of stay in the intensive care unit. Methods. Patients were divided into two groups as follows: requiring intensive care (group 1) and not requiring intensive care (group 2). The data of both groups were compared in terms of demographic characteristics, transfusion amounts, length of stay in the intensive care unit, maternal complications, and mortality. Results. 14032 births in a tertiary center between 2011 and 2018 were evaluated in this study. During the study period, 342 patients were diagnosed with HELLP, and 32 (9.4%) of these were followed up in the intensive care unit. The length of stay in the intensive care unit was determined as 8.1 (7.2) days on average. Fresh frozen plasma, erythrocyte suspension, apheresis, and random thrombocyte transfusion were observed to be significantly more in group 1 patients. In the regression analysis, the most effective factor was found to be erythrocyte suspension and the length of stay in the intensive care unit was significantly longer in patients who had erythrocyte suspension transfusion. The receiver operating characteristic curve showed that the area under the curve value for erythrocyte transfusion was 70.6%. When the cutoff value of erythrocyte suspension was 450 (95% CI: 365–681) ml, the sensitivity was 43.8% and the specificity was 91.6%. Conclusion. We think that physicians should be careful that maternal morbidity and mortality may increase as the need for erythrocyte suspension transfusion increases in patients with HELLP syndrome. Minimum transfusion to hemodynamically stable patients can be more suitable in terms of morbidity and mortality in managing patients with HELLP syndrome requiring erythrocyte suspension transfusion. Precautions and measures should be taken in this regard.

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Section: Discussionmentioning

confidence: 99%

Factors Affecting ICU Stay and Length of Stay in the ICU in Patients with HELLP Syndrome in a Tertiary Referral Hospital

Ağaçayak

Buğday

Peker

et al. 2022

International Journal of Hypertension

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“…9 HELLP sendorumu ciddi preeklampsiye sekonder geliştiğinde patogenezinde anormal plasentasyon gelişimi ve fonksiyonu suçlanırken, bağımsız bir hastalık tablosu olarak düşünüldüğünde, anormal plasentasyonun yanında, aşırı hepatik inflamasyon ve koagülasyon sistem aktivasyonunun da hastalı-ğın gelişiminde rol oynadığı gösterilmiştir. 10 HELLP sendromu, en sık epigastrium ortasında hassasiyet, karın sağ üst kadran ağrısı ya da sternum altındaki ağrı ile prezente olmaktadır.…”

Section: Discussionunclassified

A Case of HELLP Syndrome Complicated with Acute Pancreatitis

Bakar¹,

Aydın²,

Aydin³

et al. 2016

Turkiye Klinikleri J Gynecol Obst

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Ö ÖZ ZE ET T HELLP sendromu preeklampsinin bir komplikasyonu olarak gelişen hemoliz, yükselmiş karaciğer enzimleri ve düşük trombosit sayısı ile karakterize ciddi bir tablodur. Ağır preeklampsi ve eklampsi hastalarının %10-20'sinde görülür ve yüksek maternal morbidite ve mortalite ile seyreder . Pankreas dokusunun akut inflamasyonu olan akut pankreatit, morbidite ve mortaliteye yol açan ciddi sistemik komplikasyonların görüldüğü geniş spektrumlu bir hastalık olup gebelikte nadiren görümektedir. Akut pankreatitin gebelikte görülme oranı 1/1000 -1/12,000 arasında değişmekte ve hastalık olguların çoğunda üçüncü trimesterde ortaya çıkmaktadır. Bu çalışmada, 35 hafta 6 gün gestasyonel yaşı olan preeklampsi nedeni ile sezaryen ile gebeliği sonlandırılan, postoperatif HELLP sendomu geçiren ve akut pankreatit ile komplike olmuş bir olgu sunulmmuştur. Karın ağrısı, bulantı, kusma şikâyetleri olan olgularda akut panreatit gibi letal komplikasyonlara yol açabilecek bir hastalık gözden kaçırılmamalı ve tanıya yardımcı görüntüleme yöntemlerinden ve laboratuvar tetkiklerinden faydalanılmalıdır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : HELLP sendromu; pankreatit A AB BS S T TR RA AC CT T The HELLP syndrome is a serious complication in pregnancy characterized by hemolysis, elevated liver enzymes and low platelet count occurring in 10-20% of cases preeclampsia, associated with maternal morbidity and mortality. Acute pancreatitis, defined as acute inflammation of pancreas, is a broad spectrum disease which rarely seen in pregnancy associated with serious systemic complication that causes morbidity and mortality. The incidence of acute pancreatitis in pregnancy is between 1/1000 and 1/12000. Most of the cases in pregnancy occur in third trimester. In this case report, we presented a preeclampsia with 35 weeks 6 days of gestation delivered via cesarean delivery then complicated with HELLP syndrome and acute pancreatitis. In patients with complaint of abdominal pain, nausea and vomiting diseases such as acute pancreatitis that causes lethal complications should not be missed and appropriate imaging methods and laboratory test should be used for diagnosis. K Ke ey y W Wo or rd ds s: : HELLP syndrome; pancreatitis T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J G Gy yn ne ec co ol l O

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HELLP sendromu

Cited by 2 publications

References 56 publications

Factors Affecting ICU Stay and Length of Stay in the ICU in Patients with HELLP Syndrome in a Tertiary Referral Hospital

Factors Affecting ICU Stay and Length of Stay in the ICU in Patients with HELLP Syndrome in a Tertiary Referral Hospital

A Case of HELLP Syndrome Complicated with Acute Pancreatitis

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