Helium-Oxygen Therapy for Infants With Bronchiolitis

Abstract

To compare nebulized racemic epinephrine delivered by 70% helium and 30% oxygen or 100% oxygen followed by helium-oxygen inhalation therapy via high-flow nasal cannula (HFNC) vs oxygen inhalation via HFNC in the treatment of bronchiolitis.

Helium–oxygen in bronchiolitis—A systematic review and meta‐analysis

“…Of these, 22 were further assessed in the full-text phase. Six RCTs were found, [12][13][14][15]17,18 and all of these were included in the final analysis. We did not find any additional studies from other sources to be included (the references of the included studies were checked; see Figure 1).…”

Comparison of Kristjansson Respiratory Score and Wang Respiratory Score in infants with bronchiolitis in a hospital emergency department

“…Most of the previous comparative studies between two scores, or treatments efficacy studies using one specific score, were conducted in inpatients and only few studies have been conducted in an emergency department environment and outpatients. 21 , 25 , 26 , 27 This is probably due to the fact that it is easier to obtain a sample of hospitalized patients than that of outpatients, since it is unpredictable when eligible patients access the emergency department and are in conditions to be discharged home. In our study, although recognizing the challenges of recruiting patients in the emergency department, we specifically tried to evaluate the performance of respiratory scores used by different health professionals in an emergency department.…”

A pilot study of heated and humidified low flow oxygen therapy: An assessment in infants with mild and moderate bronchiolitis (HHOT AIR study)

“…There are many studies that explored various treatment modalities for acute bronchiolitis but none has been shown to be considerably effective . Supportive care remains as the mainstay treatment for bronchiolitis.…”