Heliox for croup in children

Abstract

At present there is a lack of evidence to establish the effect of heliox inhalation in the treatment of croup in children. A methodologically well-designed and adequately powered RCT is needed to assess whether there is a role for heliox therapy in the management of children with croup.

Heliox for croup in children

“…Treatment of croup with heliox has demonstrated a beneficial effect, albeit in a small numbers of patients (Beckmann 2000;DiCecco 2004;Duncan 1979;Nelson 1982;Smith 1999) and in one study the benefit appeared to be no different to nebulised epinephrine (Weber 2001). No significant evidence of benefit was reported in the previous version of this review (Vorwerk 2010), but there are new data from a Spanish randomised controlled trial (RCT) to suggest that heliox, when added to corticosteroids, clinically improves moderate croup (Pardillo 2009). Also a recently published retrospective cohort study indicates that heliox, when added to standard treatment for transporting critically ill children with croup, provides rapid and sustained improvement in croup scores with no extension of length of stay in the intensive care unit (ICU) (Kline-Krammes 2012).…”

Heliox for croup in children

“…Treatment of croup with heliox has demonstrated a beneficial effect, albeit in a small numbers of patients (Beckmann 2000;DiCecco 2004;Duncan 1979;Nelson 1982;Smith 1999) and in one study the benefit appeared to be no different to nebulised epinephrine (Weber 2001). No significant evidence of benefit was reported in the previous version of this review (Vorwerk 2010), but there are new data from a Spanish randomised controlled trial (RCT) to suggest that heliox, when added to corticosteroids, clinically improves moderate croup (Pardillo 2009). Also a recently published retrospective cohort study indicates that heliox, when added to standard treatment for transporting critically ill children with croup, provides rapid and sustained improvement in croup scores with no extension of length of stay in the intensive care unit (ICU) (Kline-Krammes 2012).…”

Heliox for croup in children

“…The benefit of heliox appeared not to di er from that of nebulised epinephrine in one study (Weber 2001). No significant evidence of benefit was reported in a previous version of this review (Vorwerk 2010), but data from a Spanish randomised controlled trial suggested that heliox, when added to corticosteroids, clinically improves moderate croup (Pardillo 2009). A published retrospective cohort study indicated that heliox, when added to standard treatment for transporting critically ill children with croup, provides rapid and sustained improvement in croup scores with no extension of length of stay in the intensive care unit (Kline-Krammes 2012).…”

“…We thank C Vorwerk and TJ Coats, who wrote the 2010 version of this review (Vorwerk 2010). We thank the referees who provided feedback on the dra review, including Carlos Cuello, Noorin Bhimani, Gina Neto, Elaine Beller, and Anca Zalmanovici Trestioreanu; and Sarah Thorning and Justin Clark, Cochrane Acute Respiratory Infections Group Information Specialists, for conducting and updating the searches.…”

“…This review is based on the withdrawn review by C Vorwerk and TJ Coats (Vorwerk 2010). The current author team updated the searches and made considerable changes to the text.…”

Ventilation distribution in rats: Part I - The effect of gas composition as measured with electrical impedance tomography

“…: the use of helium-oxygen mixtures to treat patients with severe upper airway obstruction or asthma [26,27]. With the introduction of lung imaging techniques such as He3MRI, the impact of gas properties on ventilation distribution needs to be addressed.…”

Heliox for croup in children

“…Treatment of croup with heliox has demonstrated a beneficial effect, albeit in a small numbers of patients (Beckmann 2000;DiCecco 2004;Duncan 1979;Nelson 1982;Smith 1999) and in one study the benefit appeared to be no different to nebulised epinephrine (Weber 2001). No significant evidence of benefit was reported in the previous version of this review (Vorwerk 2010), but there are new data from a Spanish randomised controlled trial (RCT) to suggest that heliox, when added to corticosteroids, clinically improves moderate croup (Pardillo 2009). Also a recently published retrospective cohort study indicates that heliox, when added to standard treatment for transporting critically ill children with croup, provides rapid and sustained improvement in croup scores with no extension of length of stay in the intensive care unit (ICU) (Kline-Krammes 2012).…”

Heliox for croup in children

“…The benefit of heliox appeared not to di er from that of nebulised epinephrine in one study (Weber 2001). No significant evidence of benefit was reported in a previous version of this review (Vorwerk 2010), but data from a Spanish randomised controlled trial suggested that heliox, when added to corticosteroids, clinically improves moderate croup (Pardillo 2009). A published retrospective cohort study indicated that heliox, when added to standard treatment for transporting critically ill children with croup, provides rapid and sustained improvement in croup scores with no extension of length of stay in the intensive care unit (Kline-Krammes 2012).…”

“…We thank C Vorwerk and TJ Coats, who wrote the 2010 version of this review (Vorwerk 2010). We thank the referees who provided feedback on the dra review, including Carlos Cuello, Noorin Bhimani, Gina Neto, Elaine Beller, and Anca Zalmanovici Trestioreanu; and Sarah Thorning and Justin Clark, Cochrane Acute Respiratory Infections Group Information Specialists, for conducting and updating the searches.…”

“…This review is based on the withdrawn review by C Vorwerk and TJ Coats (Vorwerk 2010). The current author team updated the searches and made considerable changes to the text.…”

Ventilation distribution in rats: Part I - The effect of gas composition as measured with electrical impedance tomography

“…: the use of helium-oxygen mixtures to treat patients with severe upper airway obstruction or asthma [26,27]. With the introduction of lung imaging techniques such as He3MRI, the impact of gas properties on ventilation distribution needs to be addressed.…”

Heliox for croup in children

“…Treatment of croup with heliox has demonstrated a beneficial effect, albeit in a small numbers of patients (Beckmann 2000;DiCecco 2004;Duncan 1979;Nelson 1982;Smith 1999) and in one study the benefit appeared to be no different to nebulised epinephrine (Weber 2001). No significant evidence of benefit was reported in the previous version of this review (Vorwerk 2010), but there are new data from a Spanish randomised controlled trial (RCT) to suggest that heliox, when added to corticosteroids, clinically improves moderate croup (Pardillo 2009). Also a recently published retrospective cohort study indicates that heliox, when added to standard treatment for transporting critically ill children with croup, provides rapid and sustained improvement in croup scores with no extension of length of stay in the intensive care unit (ICU) (Kline-Krammes 2012).…”

Heliox for croup in children

“…The benefit of heliox appeared not to di er from that of nebulised epinephrine in one study (Weber 2001). No significant evidence of benefit was reported in a previous version of this review (Vorwerk 2010), but data from a Spanish randomised controlled trial suggested that heliox, when added to corticosteroids, clinically improves moderate croup (Pardillo 2009). A published retrospective cohort study indicated that heliox, when added to standard treatment for transporting critically ill children with croup, provides rapid and sustained improvement in croup scores with no extension of length of stay in the intensive care unit (Kline-Krammes 2012).…”

“…We thank C Vorwerk and TJ Coats, who wrote the 2010 version of this review (Vorwerk 2010). We thank the referees who provided feedback on the dra review, including Carlos Cuello, Noorin Bhimani, Gina Neto, Elaine Beller, and Anca Zalmanovici Trestioreanu; and Sarah Thorning and Justin Clark, Cochrane Acute Respiratory Infections Group Information Specialists, for conducting and updating the searches.…”

“…This review is based on the withdrawn review by C Vorwerk and TJ Coats (Vorwerk 2010). The current author team updated the searches and made considerable changes to the text.…”

Ventilation distribution in rats: Part I - The effect of gas composition as measured with electrical impedance tomography

“…: the use of helium-oxygen mixtures to treat patients with severe upper airway obstruction or asthma [26,27]. With the introduction of lung imaging techniques such as He3MRI, the impact of gas properties on ventilation distribution needs to be addressed.…”