Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms

Nam, Ji Hyung; Hong, Chang Won; Kim, Jae Hak; Shin, Aesun; Ryu, Kum Hei; Park, Bum-Joon; Kim, Bun; Sohn, Dae Kyung; Han, Kyung Su; Kim, Jeongseon; Lee, Chan Wha

doi:10.1007/s10552-016-0839-x

Cited by 46 publications

(41 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a Korean study on 4,466 subjects who underwent screening colonoscopy and esophagogastroduodenoscopy (EGD), H. pylori infection was associated with a twofold increase in the risk of advanced colon adenomas and multiple colon adenomas. 20 Similar data were reported in a retrospective cross-sectional study on 6,351 Korean subjects (mean age 51.7±8.1 years) who had a GI endoscopy for screening purposes. 21 In this study, Lee et al Previous studies, however, showed that the observed relationship between H. pylori and CRC could be population related.…”

Section: H Pylori and Colorectal Cancersupporting

confidence: 83%

“…Colorectal cancer (CRC) has been confirmed to be positively associated with H. pylori . In a Korean study on 4,466 subjects who underwent screening colonoscopy and esophagogastroduodenoscopy (EGD), H. pylori infection was associated with a twofold increase in the risk of advanced colon adenomas and multiple colon adenomas …”

Section: H Pylori and Colorectal Cancermentioning

confidence: 99%

See 1 more Smart Citation

Helicobacter pylori, gastric cancer and other gastrointestinal malignancies

et al. 2017

View full text Add to dashboard Cite

In a retrospective study performed in California, U.S.A., ca. 3% of patients with gastric intestinal metaplasia (GIM) developed gastric cancer (GC) within a median time period of 4.6 years after diagnosis of GIM. This observation stresses the importance of targeted surveillance even in regions with a low GC prevalence. Patients with alcoholic liver disease as well as survivors of colorectal and lobular breast cancer were found to be at increased risk of secondary GC. A population-based Chinese study confirmed "serologic biopsy" as a useful screening tool for stratifying the individual risk of developing GC. Concerning GC therapy, a post hoc analysis of the MAGIC trial reported that regression of lymph node metastases, but not the tumor regression itself, predicts overall survival. Furthermore, in patients with high microsatellite instable tumors, perioperative chemotherapy leads to an increased risk of mortality. Two studies confirmed that eradication therapy is worthwhile as an initial treatment for gastric mucosa-associated lymphoid tissue (MALT) lymphoma irrespective of the H. pylori infection status and stage. An increased risk of a second primary malignancy including GC was observed in these patients treated with immuno/chemotherapy but not in patients treated solely with an H. pylori eradication treatment. With respect to gastrointestinal malignancies other than GC, discrepant data have been published regarding the association of H. pylori with pancreatic cancer whereas no association has been reported with esophageal squamous cell carcinoma. The majority of published studies still support an association of H. pylori with colon neoplasms.

show abstract

Section: H Pylori and Colorectal Cancersupporting

confidence: 83%

Section: H Pylori and Colorectal Cancermentioning

confidence: 99%

Helicobacter pylori, gastric cancer and other gastrointestinal malignancies

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The association between H. pylori infection and CRC is still controversial with studies showing a close link with a higher prevalence of H. pylori infection in patients with colonic adenomas and carcinomas [169,170,171,172], while others do not [173,174,175]. Recent studies released in 2017 have suggested indeed a significant association between H. pylori infection and an increase in CRC occurrence [176,177,178]. Yan and colleagues showed a positive association between H. pylori and CRC only when H. pylori is associated with intestinal metaplasia [178].…”

Section: Possible Mechanisms Of Action Of the Intestinal Microbiotmentioning

confidence: 99%

“…Yan and colleagues showed a positive association between H. pylori and CRC only when H. pylori is associated with intestinal metaplasia [178]. Analyzing 1245 colorectal adenomas and 3221 control subjects without polyp, Nam and colleagues showed that the overall rate of positive H. pylori infection is increased in adenoma cases compared to polyp-free control cases, and that the positive association of H. pylori infection with colorectal adenomas is more prominent in advanced adenomas and multiple adenomas [177]. Despite this controversy, some studies have tried to clarify the mechanism underlying the potential association between this pathogen and CRC with some hypotheses including release of toxin or hormone, intestinal microbiota fluctuation and chronic inflammation.…”

Section: Possible Mechanisms Of Action Of the Intestinal Microbiotmentioning

confidence: 99%

Microbiota, Inflammation and Colorectal Cancer

Lucas

Barnich

Nguyen

2017

IJMS

259

134

View full text Add to dashboard Cite

Colorectal cancer, the fourth leading cause of cancer-related death worldwide, is a multifactorial disease involving genetic, environmental and lifestyle risk factors. In addition, increased evidence has established a role for the intestinal microbiota in the development of colorectal cancer. Indeed, changes in the intestinal microbiota composition in colorectal cancer patients compared to control subjects have been reported. Several bacterial species have been shown to exhibit the pro-inflammatory and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis. This review will summarize the current knowledge about the potential links between the intestinal microbiota and colorectal cancer, with a focus on the pro-carcinogenic properties of bacterial microbiota such as induction of inflammation, the biosynthesis of genotoxins that interfere with cell cycle regulation and the production of toxic metabolites. Finally, we will describe the potential therapeutic strategies based on intestinal microbiota manipulation for colorectal cancer treatment.

show abstract

“…(8,9) Moreover, several investigations have reported an association between H. pylori infection and colorectal neoplasms. (10)(11)(12)(13) In general, risk of colorectal neoplasms increases because of some risk factors, such as lifestyle characteristics, anthropometric parameters, and metabolic syndrome. (14,15) Most colorectal neoplasms found during endoscopic examinations are adenomas that possess the potential for cancer in the adenomacarcinoma sequences.…”

mentioning

confidence: 99%

Endoscopic gastric mucosal atrophy as a predictor of colorectal polyps: a large scale case-control study

Kawahara

Kodama

Mizukami

et al. 2019

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

Although some studies have indicated a correlation betweenHelicobacter pylori infection and the risk of colorectal neoplasms, these findings have not been consistent and are controversial. This case control study aimed to investigate the association between endoscopic gastric mucosal atrophy and colorectal polyp occurrence. Records of 7,394 participants who underwent colonoscopy examinations from August 2008 to July 2018 were reviewed retrospectively. A total of 2,404 subjects were registered; 1,565 (65.1%) were in the gastric mucosal atrophy positive group and 1,138 (47.3%) had colorectal polyps. The multivariate analysis adjusted by age, sex, smoking habits, alcohol habits, hemoglobin A1c, and systolic blood pressure indicated that patients in the gastric mucosal atrophy positive group more frequently had colorectal polyps compared with patients in the gastric mucosal atrophy negative group (odds ratio, 3.27; 95% confidence interval, 2.68-4.01; p<0.001). An analysis of the association between gastric mucosal atrophy degree and colorectal polyp status indicated that, compared with mild gastric mucosal atrophy, severe gastric mucosal atrophy was associated with a higher risk of proximal colon polyps (odds ratio, 1.47; 95% confidence interval, 1.05-2.07; p = 0.024) and two or more colorectal polyps (odds ratio, 1.80; 95% confidence interval, 1.30-2.49; p<0.001). In conclusion, gastric mucosal atrophy found during esophagogastroduodenoscopy may be an indication for complete colon screening.

show abstract

Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms

Abstract: Helicobacter pylori infection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas.

Cited by 46 publications

References 48 publications

Helicobacter pylori, gastric cancer and other gastrointestinal malignancies

Helicobacter pylori, gastric cancer and other gastrointestinal malignancies

Microbiota, Inflammation and Colorectal Cancer

Endoscopic gastric mucosal atrophy as a predictor of colorectal polyps: a large scale case-control study

Contact Info

Product

Resources

About