Helicobacter pylori–associated iron-deficiency anemia in adolescent female athletes

Choe, Yon Ho; Kwon, Young Se; Jung, M.; Kang, Suk‐Ku; Hwang, Tae Sook; Hong, Yun Chui

doi:10.1067/mpd.2001.114700

Cited by 125 publications

(114 citation statements)

References 22 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…We found that H pylori infection was independently associated with iron deficiency and iron-deficiency anemia among children in this region, with high prevalences of all 3 conditions. This association has been observed in previous studies in rural Alaska 5,6,11 and elsewhere, [16][17][18][19][20][21] but never in a study that was population based, had a relatively large cohort of children, and used a validated measure of active H pylori infection. Our findings suggest that H pylori infection may be an important risk factor for iron deficiency and iron-deficiency anemia among children in rural Alaska and possibly in other areas of the world where these conditions are highly prevalent.…”

Section: Discussionmentioning

confidence: 58%

“…However, H pylori infection and iron deficiency are highly prevalent in other indigenous arctic populations and many areas of the developing world, and similar associations between H pylori and iron deficiency have been found in smaller studies in diverse populations. [16][17][18][19]21 CONCLUSIONS A significant disparity persists in the prevalence of iron deficiency between Alaska Native and other US schoolaged children, with Alaska Native children more closely resembling children from developing countries. Our data suggest that H pylori infection may be an important contributor to the disparity in this region, where endemic iron deficiency persists despite apparent adequate nutritional intake and lack of parasitosis.…”

Section: Discussionmentioning

confidence: 99%

“…However, the association was much stronger in children who were 9 years or older (PR: 3.7-4.0) and among those with irondeficiency anemia, and our findings are consistent with previous studies that evaluated the relationship between H pylori and iron deficiency in Alaska and in other settings. 5,6,11,[16][17][18][19][20][21] Confounding by unmeasured socioeconomic factors could also have occurred, but there is relatively little variation in socioeconomic status among Alaska Natives from southwestern Alaska, particularly within villages. Finally, our study was conducted in small villages in rural Alaska, which may limit the generalizability of our findings.…”

Section: Discussionmentioning

confidence: 99%

“…12 Many areas of the world with high iron deficiency prevalences also have high Helicobacter pylori prevalences, [13][14][15] including western Alaska, where seroprevalence among adults exceeds 80%. 6 Recent investigations among Alaska Natives 5,6,11 and other populations worldwide [16][17][18][19][20][21] found an association between iron deficiency and H pylori infection. Previous studies were limited by small sample sizes or the use of anti-H pylori immunoglobulin G antibody positivity as a surrogate marker of infection.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska

et al. 2006

View full text Add to dashboard Cite

OBJECTIVES. Rural Alaska Natives have a high prevalence of iron deficiency and Helicobacter pylori infection. The objective of this study was to estimate the prevalence of iron deficiency, iron-deficiency anemia, and active H pylori infection among school-aged children in rural Alaska.METHODS. We enrolled 68% (688) of the 7-to 11-year-old children from 10 predominantly Alaska Native villages in southwestern Alaska. We collected venous blood samples to assess iron deficiency and anemia. Each child was tested for active H pylori infection by 13 C-urea breath test (UBT). Evaluated risk factors included age, gender, village of residence, number of household members, number of household members who were younger than 5 years, recent antibiotic use, and household water source.RESULTS. Of 688 enrolled children, iron deficiency was present in 38%, iron-deficiency anemia was present in 7.8%, and H pylori infection by UBT was present in 86%. Iron deficiency was independently associated with living in a household with Ͼ6 people and village of residence. H pylori infection by UBT was independently associated with child's age Ն10 years and village of residence. Ninety-one percent of children with iron deficiency had H pylori infection by UBT, and children with active H pylori infection were more likely to be iron deficient than uninfected children. Children with H pylori infection by UBT were also more likely to have iron-deficiency anemia than uninfected children.CONCLUSIONS. In this study of nearly 700 children in 10 different villages in Alaska, we confirmed that the high prevalence of iron deficiency persists among schoolaged children. We found that active H pylori infection was independently associated with iron deficiency and iron-deficiency anemia among children in this region. H pylori infection may account for a portion of the iron deficiency and iron-deficiency anemia in rural Alaska and other areas with high prevalences of both conditions. Innovative approaches are critically needed to address the iron deficiency in high prevalence areas such as rural Alaska and most of the developing world. Dr Baggett assisted with study design, was the primary person responsible for study implementation during the first study year, conducted all data analysis, and was the primary manuscript author. Dr Gessner was the study primary investigator, wrote the study protocol, was the primary person responsible for study implementation during the second study year, and assisted with data analysis and preparing the manuscript. Dr Parkinson was responsible for all components of laboratory analysis, assisted with study design, and provided critical input into the final manuscript. Ms Muth assisted with study design and writing the study protocol, was the primary person responsible for administrative project management, and reviewed the final manuscript. Dr Gold contributed to the study design, data analysis, and interpretation and provided critical input into the final manuscript. 2 The prevalence of iron deficiency among children...

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Various studies are suggesting that H. pylori infection as a risk factor for iron deficiency anemia. Probably mechanisms include decreased secretion of HCL (Hydrochloric acid), achlorhydria in gastric mucosa that reduces the absorption of iron, also absorbed iron by H. pylori bacteria is the one of the mechanism [7,8].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Serum Ferritin, TIBC Level and Helicobacter pylori Infection

Tari

Shamsi

Rahimi

et al. 2016

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: In iron deficiency anemia (IDA), serum ferritin level is decreased and total iron binding capacity (TIBC) is increased Objectives: In this study the relationship between H. pylori infection and iron deficiency anemia were studied. Methods: This research was a cross-sectional study. TIBC and ferritin levels were measured in 133 patients, suspected to H. pylori infection, then serum levels of IgM and IgG antibody against H. pylori infection were measured Results: From 133 patients, 97 were females (72.93%) and 36 males (28.07%), 36 of them (23 women and 13 men) have a TIBC levels more than 400 ug/dL and ferritin levels were less than 12ng/dL. Twenty patients had IgG antibodies and 5 patients had IgM against H. pylori. Conclusions:The results show the association between H. pylori infection and increased levels of TIBC and decreased serum ferritin.

show abstract

What Is New Related to Helicobacter pylori Infection in Children and Teenagers?

Kato

Sherman²

2005

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

Helicobacter pylori infection is a common bacterial infection for humans, and the organism is the most prevalent gastric microbial pathogen. However, the major route of transmission remains poorly understood. The outcome of chronic H pylori infection varies from asymptomatic gastritis to peptic ulceration and gastric malignancies. Recently, H pylori has been associated with the development of extradigestive disorders, including refractory iron-deficiency (sideropenic) anemia and chronic autoimmune thrombocytopenic purpura. Virulence factors of H pylori and host genetic factors are both considered important determinants of disease outcome. Multiple tests, including novel noninvasive approaches, are available for establishing the presence of H pylori infection, but there is still little consensus about which study should be performed and in what clinical setting. Eradicating H pylori uses combination therapy, including a proton pump inhibitor and 2 antibiotics taken twice daily for 7 to 14 days. Antibiotic resistance is a growing and serious problem that interferes with the success of eradication therapy. Testing and eradication therapy for H pylori are currently recommended only for the subset of infected persons in whom the disease sequelae are proven or highly suspected.

show abstract

Helicobacter pylori–associated iron-deficiency anemia in adolescent female athletes

Cited by 125 publications

References 22 publications

Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska

Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska

Relationship Between Serum Ferritin, TIBC Level and Helicobacter pylori Infection

What Is New Related to Helicobacter pylori Infection in Children and Teenagers?

Contact Info

Product

Resources

About