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Cited by 200 publications
(226 citation statements)
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References 35 publications
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“…Sigal et al also reported an increase of the number of antral Lgr5 + cells in H. pylori-associated gastritis and carcinoma in humans. As these cells are susceptible to DNA damage, it suggests that Lgr5 + stem cells could be at the origin of cancer [38,39]. An Lgr5 mice leads to adenoma formation in the gastric antrum, but not in the corpus [7].…”
Section: Tumors Can Originate From Epithelial Stem Cell Transformationmentioning
confidence: 99%
“…Sigal et al also reported an increase of the number of antral Lgr5 + cells in H. pylori-associated gastritis and carcinoma in humans. As these cells are susceptible to DNA damage, it suggests that Lgr5 + stem cells could be at the origin of cancer [38,39]. An Lgr5 mice leads to adenoma formation in the gastric antrum, but not in the corpus [7].…”
Section: Tumors Can Originate From Epithelial Stem Cell Transformationmentioning
confidence: 99%
“…Stem cells are critical for regulating the self-renewing gastric epithelium and maintaining homeostasis, and evidence from mouse models and human tissue has indicated that H. pylori can interact with stem cell populations[27]. In vivo lineage tracing of the gastric epithelium has demonstrated that Lgr5 (leucine-rich repeat-containing G protein-coupled receptor 5) positive cells are self-renewing, multipotent stem cells capable of generating an entire antral gastric gland[28].…”
Section: Host Factors and Gastric Cancermentioning
confidence: 99%
“…Furthermore, in H. pylori -infected persons with cancer, Lgr5-positive cells are more susceptible to DNA damage than Lgr5-negative cells[29]. A recent novel study using 3D-confocal microscopy has demonstrated that H. pylori can specifically interact with Lgr5 + progenitor and stem cells, leading to their functional activation[27]. …”
Section: Host Factors and Gastric Cancermentioning
confidence: 99%
“…To persist in the highly acidic stomach, H. pylori populate the mucus layer that covers and protects the epithelium [18]. The bacteria have the ability to actively sense the epithelium [19] and a subpopulation attaches directly to it, penetrating deep into the epithelial gastric glands to grow on intercellular junctions of progenitor and stem cells [20]. It has been described that attachment to host cells and injection of the virulence factor CagA is important for H. pylori to acquire nutrients and micronutrients [21,22,23].…”
mentioning
confidence: 99%
“…It has been impressively demonstrated that bacterial muramyl dipeptide, a peptidoglycan component common to all bacteria, is sensed directly by stem cells, enhancing the survival and proliferation of crypt stem cells [33]. Hyperproliferative and hyperplastic epithelial responses have been found in different gastrointestinal infections, including H. pylori and Citrobacter rodentium [20,34], reminiscent of such mechanical pathogen clearance.…”
mentioning
confidence: 99%