Helicobacter pylori 30ans après : quoi de neuf ?

Korwin, J. D. De

doi:10.1016/j.revmed.2014.01.009

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…The CNRCH in France in 2019, Naïma in 2018 in Algeria, and Bouihat in 2017 in Morocco did not find resistance to tetracycline.Resistance to metronidazole affects several genes. It was on average 3 times higher than for macrolides worldwide in 20149 . In this study, we determined a sensitivity rate of 15.25% and a resistance rate of 74.58%.…”

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confidence: 81%

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Biochemical and resistance profile of Helicobacter pylori isolated in N’Djamena in Chad

Nadlaou

Moussa

Habkreo

et al. 2021

J. Drug Delivery Ther.

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Helicobacter pylori infection and resistance to antibiotics is a public health problem. The objective of this study was to determine the prevalence and rates of resistance to antibiotics used in the protocol for the management of patients with Helicobacter pylori infection. Spanning a period from February 2020 to February 2021, it was an observational diagnostic study on gastric biopsies and stool including 97 patients admitted for endoscopy. It was carried out according to standard methods of medical microbiology. Of 97 patients whose mean age was 46.10 years with extremes of 16 and 85 years, an infection prevalence of 60.82% was observed. 44.07% of infected patients were between 16 and 39 years old, 33.90% between 40 and 63 years old, and 22.03% between 63 and 85 years old. Significant differences were observed between the proportions of positive (81.44%) and negative (18.56%) cultures, between infection with H. pylori (75%) and other microbial agents (25.35%) with probabilities of 0.01 and 0.02 respectively. The most resistant antibiotics were: Metronidazole, Clarithromycin, Levofloxacin, Tetracycline and Amoxicillin with resistance rates of 74.58%, 16.95%, 13.56%, 8.47%, and 5.08% respectively. The frequencies of antibiotic resistance revealed 74.58% for Metronidazole, 16.95% for Clarithromycin, 13.56% for Levofloxacin, 8.47% for Tetracycline, and 5.08% for Amoxicillin. This study made it possible to determine a significant proportion of H. pylori infection and to shed light on the resistance to the antibiotics used in the eradicating treatment of the bacteria. From this study, we retain that the prescription of Metronidazole is prohibited in Chad. Keywords: Helicobacter pylori, Resistance, Antibiotic, Chad.

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confidence: 81%

“…Thirty years later, medicine is faced with the problem of H. pylori's resistance to antibiotics. This resistance is mainly to clarithromycin, a very effective macrolide when administered in combination, but also to imidazoles, fluoroquinolones and to a lesser extent other antibiotic 8, 9 .…”

Section: Introductionmentioning

confidence: 99%

Biochemical and resistance profile of Helicobacter pylori isolated in N’Djamena in Chad

Nadlaou

Moussa

Habkreo

et al. 2021

J. Drug Delivery Ther.

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Helicobacter pylori : quand rechercher une infection et la traiter chez l’adulte ?

Korwin

2021

La Revue de Médecine Interne

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Histo-epidemiological aspect of Helicobacter pylori chronic gastritis in a Moroccan population

Gui

Hechlaf²,

Ed-Day

et al. 2021

E3S Web Conf.

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Helicobacter pylori (H. Pylori) is the best example of the implication of chronical infection in carcinogenesis. The World Health Organization recognized it as a class I carcinogen since it triggers the progression of premalignant gastric lesions. The aim of this study is to define the prevalence of H. Pylori infection, related risk factors, and explore the histological features of the chronic gastritis. This is a retrospective study of 248 gastric specimens, examinated and evaluated according Sydney to system. The prevalence of H. Pylori is 67 %, chronic gastritis is observed in all the biopsies (100%). Age and gender were not a risk factors for the H. Pylori infection. Prevalence of H. Pylori was 71.93% in low socio-economic class. The severity of the chronic gastritis increases if the colonization of H. Pylori increases. In 74, 58% of cases chronic gastritis was active. Glandular atrophy presented 10.37% and in 80% was related to H. Pylori infection (p=0,004) and 12 % related to autoimmune diseases. The prevalence of Intestinal metaplasia is 10.53%, and H. Pylori was observed in 42.31% of cases (p=0.001). The dysplasia is detected in one case, in a 72 years old patient. We also observed one case of gastric adenocarcinoma, of an 80 years. Follicular gastritis are in 32% of cases, and they were more frequent in H. Pylori infected slides (82% of subjects) (p< 0.005).According to this study, H. Pylori Chronic Gastritis is very common in our population, and a coherent relationship exists between H. Pylori colonization and pre-cancerous lesions. An early eradicating should be considered as a health goal.

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Helicobacter pylori 30ans après : quoi de neuf ?

Cited by 3 publications

References 17 publications

Biochemical and resistance profile of Helicobacter pylori isolated in N’Djamena in Chad

Biochemical and resistance profile of Helicobacter pylori isolated in N’Djamena in Chad

Helicobacter pylori : quand rechercher une infection et la traiter chez l’adulte ?

Histo-epidemiological aspect of Helicobacter pylori chronic gastritis in a Moroccan population

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