Helicobacter felis Eradication Restores Normal Architecture and Inhibits Gastric Cancer Progression in C57BL/6 Mice

Inflammation, atrophy, and gastric cancer

“…Although this study showed minimal benefit to patients with established atrophy, overall, studies of the effect of H. pylori eradication on gastric atrophy have been conflicting (111); some studies show improvements in atrophy with eradication (112,113), whereas others show little or no improvement (114). The issue of reversibility of gastric atrophy has been examined in C57BL/6 mice infected with H. felis and then given 3 different antibiotics for 14 days 2, 6, or 12 months after infection (94). Antibiotic therapy 2 and 6 months after infection resulted in reversal of atrophy and restoration of normal gastric architecture, whereas bacterial eradication 1 year after infection resulted in some restoration of parietal cell mass and prevention of further progression of dysplasia in most animals (94).…”

“…This pathological process is very similar to that which develops in H. felis-infected wild-type mice, again after long-standing achlorhydria and after Helicobacter spp. are almost undetectable (94). Evidence thus far indicates that H. pylori is more important as a trigger for the development of gastric atrophy and achlorhydria than as a promoter of advanced gastric cancer.…”

“…The issue of reversibility of gastric atrophy has been examined in C57BL/6 mice infected with H. felis and then given 3 different antibiotics for 14 days 2, 6, or 12 months after infection (94). Antibiotic therapy 2 and 6 months after infection resulted in reversal of atrophy and restoration of normal gastric architecture, whereas bacterial eradication 1 year after infection resulted in some restoration of parietal cell mass and prevention of further progression of dysplasia in most animals (94). Although some questions have been raised regarding the worsening of gastroesophageal reflux after H. pylori eradication (115), most studies have not confirmed an increase in gastroesophageal reflux in patients whose H. pylori infection has been eradicated (116)(117)(118)(119).…”

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

“…Studies using animal models have also confirmed that gastric cancer development can be prevented by early eradication of the microorganism (14,151) .…”

Preventive effects of etodolac, a selective cyclooxygenase‐2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori‐negative precancerous lesion

“…3 H. pylori eradication thus appears to be the most promising approach for the control of gastric cancer development, and the results of animal experiments have revealed that eradication of H. pylori, especially in the early stage, is effective for preventing stomach carcinogenesis. [4][5][6] However, current data indicate that H. pylori eradication does not lead to complete eradication of gastric cancer [7][8][9][10][11][12] and might be effective only in subjects without chronic atrophic gastritis (CAG) together with intestinal metaplasia. 7,10 Moreover, patients with extensive intestinal metaplasia-that is, metaplastic gastritis-should not be treated with eradication therapy, as bacterial load decreases with the progression of intestinal metaplasia, eventually resulting in spontaneous eradication.…”