Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review)

Katoh, Yuriko; Katoh, Masaru

doi:10.3892/ijmm.18.6.1019

Cited by 123 publications

(171 citation statements)

References 52 publications

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“…The HH gene family, which codes a much more sophisticated set of secreted proteins, was first identified (3,30,31). SHH is active only in stem cells and/or endodermal progenitor in adults (16,23).…”

Section: Discussionmentioning

confidence: 99%

“…SHH is active only in stem cells and/or endodermal progenitor in adults (16,23). Recent studies showed that aberrant signaling of this pathway is involved in a variety of human cancers (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). The HH pathway essentially consists of PTCH, the motive protein, SMOH, and the transcriptional factors GLI2 and GLI3.…”

Section: Discussionmentioning

confidence: 99%

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Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients

Li¹,

Che²,

Yanhua³

et al. 2012

Chin. J. Cancer Res.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients

Li¹,

Che²,

Yanhua³

et al. 2012

Chin. J. Cancer Res.

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“…3,31,37,48,49 We hypothesized that Hh signaling was likely to be involved in the latter process, because Hh ligands orchestrate the development of many tissues, as well as remodeling of damaged epithelia in various adult organs. 13,18,19,21,41 Although Hh signaling is not known to regulate adult liver regeneration, 2 evidence that mesendodermal-like cells in fetal livers exhibit Hh pathway activity, 11,25,26 and that chronic biliary injury induces …”

Section: Discussionmentioning

confidence: 99%

“…Gli activity promotes epithelial-mesenchymal transitions. 13,18,41,42 Therefore, we compared fibrosis markers in ethionine-treated lean and ob/ob mice. Although others have reported reduced fibrotic responses in ob/ob mice, 43,44 we found that ob/ob mice expressed higher mRNA levels of collagen 1aI (col1aI) (Figure 8a), asma (Figure 8b), and transforming growth factor-b (TGF-b) (Figure 8c) than lean mice after ethionine treatment.…”

Section: Hedgehog Activity and Nash Sv Fleig Et Almentioning

confidence: 99%

Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice

Fleig

Choi

Yang

et al. 2007

Laboratory Investigation

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“…MAPK/ERK signaling is active in undifferentiated human ES cells and is down-regulated upon differentiation [48]. These signaling pathways may thus constitute a complex signaling network actively maintaining ES cell pluripotency [49][50][51][52][53][54][55][56][57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells

et al. 2008

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npg Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their overexpression can induce pluripotency in both mouse and human somatic cells, indicating that these factors regulate the developmental signaling network necessary for ES cell pluripotency. However, systemic analysis of the signaling pathways regulated by Yamanaka factors has not yet been fully described. In this study, we identified the target promoters of endogenous Yamanaka factors on a whole genome scale using ChIP (chromatin immunoprecipitation)-on-chip in E14.1 mouse ES cells, and we found that these four factors co-occupied 58 promoters. Interestingly, when Oct4 and Sox2 were analyzed as core factors, Klf4 functioned to enhance the core factors for development regulation, whereas c-Myc seemed to play a distinct role in regulating metabolism. The pathway analysis revealed that Yamanaka factors collectively regulate a developmental signaling network composed of 16 developmental signaling pathways, nine of which represent earlier unknown pathways in ES cells, including apoptosis and cellcycle pathways. We further analyzed data from a recent study examining Yamanaka factors in mouse ES cells. Interestingly, this analysis also revealed 16 developmental signaling pathways, of which 14 pathways overlap with the ones revealed by this study, despite that the target genes and the signaling pathways regulated by each individual Yamanaka factor differ significantly between these two datasets. We suggest that Yamanaka factors critically regulate a developmental signaling network composed of approximately a dozen crucial developmental signaling pathways to maintain the pluripotency of ES cells and probably also to induce pluripotent stem cells.

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Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review)

Cited by 123 publications

References 52 publications

Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients

Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients

Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice

Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells

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