The heat transfer characteristics of propylene glycol-water (PG-W) mixture (10%, 20%, and 30% propylene glycol) on the shell side of a spiral-wound heat exchanger (SWHE) were investigated experimentally. Among the SWHE selected, there are 18 twined tubes with a diameter of 8 mm. PG-W mixture is on the shell side and water is on the tube side. The results show that the heat transfer coefficient of PG-W mixture flowing downwards is higher than upwards under countercurrent conditions. The heat transfer coefficient decreases with the increasing of concentration of PG-W mixture. When the inclination angle of the SWHE is 90°, the heat transfer coefficient of PG-W mixture is the largest; and when the inclination angle is less than 90°, the heat transfer coefficient decreases with the decrease of inclination angle. The inclination angle has a great effect on the heat transfer coefficient at a high concentration. The fitting correlation equations between Nu, Re, Pr, and inclination angles of SWHE are established.