Heat Shock Proteins in Leishmania Parasites

Kröber-Boncardo, Constanze; Grünebast, Janne; Clos, Joachim

doi:10.1007/7515_2020_27

Cited by 3 publications

(2 citation statements)

References 120 publications

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“…The members of the family Trypanosomatidae express highly conserved members of HSP families. Leishmania species possess a full set of HSPs that play an important role in the biphasic life cycle of the parasite [ 184 , 185 ]. These proteins are highly abundant in both stages of the parasite.…”

Section: Virulence Factors Of Leishmaniamentioning

confidence: 99%

Insights into Leishmania Molecules and Their Potential Contribution to the Virulence of the Parasite

Elmahallawy

Alkhaldi

2021

Veterinary Sciences

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Neglected parasitic diseases affect millions of people worldwide, resulting in high morbidity and mortality. Among other parasitic diseases, leishmaniasis remains an important public health problem caused by the protozoa of the genus Leishmania, transmitted by the bite of the female sand fly. The disease has also been linked to tropical and subtropical regions, in addition to being an endemic disease in many areas around the world, including the Mediterranean basin and South America. Although recent years have witnessed marked advances in Leishmania-related research in various directions, many issues have yet to be elucidated. The intention of the present review is to give an overview of the major virulence factors contributing to the pathogenicity of the parasite. We aimed to provide a concise picture of the factors influencing the reaction of the parasite in its host that might help to develop novel chemotherapeutic and vaccine strategies.

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Section: Virulence Factors Of Leishmaniamentioning

confidence: 99%

Insights into Leishmania Molecules and Their Potential Contribution to the Virulence of the Parasite

Elmahallawy

Alkhaldi

2021

Veterinary Sciences

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“…Conversion into amastigotes is crucial for survival within the mammalian host and thus plays an important role in the pathogenicity of Leishmania spp.. The pivotal role of heat shock proteins in differentiation and adaption was proposed early and has been extensively studied in Leishmania [21] .…”

Section: Introductionmentioning

confidence: 99%

Leishmania: Responding to environmental signals and challenges without regulated transcription

Grünebast

Clos

2020

Computational and Structural Biotechnology Journal

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Here we describe the non-canonical control of gene expression in Leishmania , a single-cell parasite that is responsible for one of the major neglected tropical diseases. We discuss the lack of regulated RNA synthesis, the post-transcriptional gene regulation including RNA stability and regulated translation. We also show that genetic adaptations such as mosaic aneuploidy, gene copy number variations and DNA sequence polymorphisms are important means for overcoming drug challenge and environmental diversity. These mechanisms are discussed in the context of the unique flow of genetic information found in Leishmania and related protists.

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Promastigote-to-Amastigote Conversion in Leishmania spp.—A Molecular View

2022

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A key factor in the successful infection of a mammalian host by Leishmania parasites is their conversion from extracellular motile promastigotes into intracellular amastigotes. We discuss the physical and chemical triggers that induce this conversion and the accompanying changes at the molecular level crucial for the survival of these intracellular parasites. Special emphasis is given to the reliance of these trypanosomatids on the post-transcriptional regulation of gene expression but also to the role played by protein kinases, chaperone proteins and proteolytic enzymes. Lastly, we offer a model to integrate the transduction of different stress signals for the induction of stage conversion.

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Heat Shock Proteins in Leishmania Parasites

Cited by 3 publications

References 120 publications

Insights into Leishmania Molecules and Their Potential Contribution to the Virulence of the Parasite

Insights into Leishmania Molecules and Their Potential Contribution to the Virulence of the Parasite

Leishmania: Responding to environmental signals and challenges without regulated transcription

Promastigote-to-Amastigote Conversion in Leishmania spp.—A Molecular View

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