2012
DOI: 10.1186/1471-213x-12-32
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: BackgroundTemperature affects virtually all cellular processes. A quick increase in temperature challenges the cells to undergo a heat shock response to maintain cellular homeostasis. Heat shock factor-1 (HSF-1) functions as a major player in this response as it activates the transcription of genes coding for molecular chaperones (also called heat shock proteins) that maintain structural integrity of proteins. However, the mechanisms by which HSF-1 adjusts fundamental cellular processes such as growth, prolife… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
37
0

Year Published

2014
2014
2022
2022

Publication Types

Select...
3
2
2

Relationship

0
7

Authors

Journals

citations
Cited by 39 publications
(42 citation statements)
references
References 27 publications
5
37
0
Order By: Relevance
“…However, activating conditions failed to induce a classic HSR, as expression of both hsp-1 and daf-21 are down regulated over the first 12h, indicating that hsf-1 functions independently of the HSR in activation. HSF-1 is known to regulate development and aging in C. elegans , and has transcriptional targets that are key components of signal transduction pathways in addition to those with chaperone functions [20, 21, 25, 27, 73]. Recently Morton et al hypothesized that these targets are not transcribed by trimeric HSF-1 in heat shock granules, as occurs during stress, but rather by monomeric HSF-1 [27].…”
Section: Discussionmentioning
confidence: 99%
“…However, activating conditions failed to induce a classic HSR, as expression of both hsp-1 and daf-21 are down regulated over the first 12h, indicating that hsf-1 functions independently of the HSR in activation. HSF-1 is known to regulate development and aging in C. elegans , and has transcriptional targets that are key components of signal transduction pathways in addition to those with chaperone functions [20, 21, 25, 27, 73]. Recently Morton et al hypothesized that these targets are not transcribed by trimeric HSF-1 in heat shock granules, as occurs during stress, but rather by monomeric HSF-1 [27].…”
Section: Discussionmentioning
confidence: 99%
“…These data suggest that the temperature sensing neurons can infl uence the activity of the endocrine pathways involved in dauer formation. This may be mediated by changes in the activity of heat-shock factor-1 [ 43 ].…”
Section: Sensory Inputs Affecting Dauer Formationmentioning
confidence: 96%
“…At a moderate heat (42.5°C) the phosphorylation of this receptor shows a transient pattern having an increased activity for a few minutes followed by a downregulation in parallel with ERK1/2 activation ( Figure 3.13 and Figure 3.14). It is well established that glucose deprivation induces HSP synthesis through the downregulation of IGF1R/IR pathway (Chiang et al 2012;Barna et al 2012;Hsu, Murphy, and Kenyon 2003;Hooper and Hooper 2005). This effect is completely antagonized by dexamethasone, the synthetic glucocorticoid which is a well know membrane fluidizing agent with the ability to remodel cellular lipid composition (Kasambalides and Lanks 1985).…”
Section: Igf1r Signallingmentioning
confidence: 99%
“…The connection has been made long ago when increase in lifespan was observed in worms and flies when insulin-like growth factor 1 (IGF-1) signalling was disrupted and resulted in upregulation of the stress resistance genes ( signalling causes HSF1 to be released and causes more stress induced HSF-1 to be available (Barna et al 2012;Chiang et al 2012). The second level of regulation is through the Akt pathway which negatively regulates HSF1 through indirect phosphorylation on Ser303 (Chu et al 1996;X.…”
Section: Membrane Sensor Theorymentioning
confidence: 99%
See 1 more Smart Citation