Heart valve replacement with the Ionescu-Shiley pericardial xenograft

Ionescu, Marian I.; Tandon, Anand P.; Mary, David A.S.G.; Abid, A.; McGoon, Dwight C.

doi:10.1016/s0022-5223(19)39979-9

Cited by 145 publications

(22 citation statements)

References 17 publications

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“…Ionescu et al (8) introduced a procedure for preserving and shaping BP that involves fixing the tissue with a 0.5% GA solution. In this circumstance, the molecular structure is permanently changed, with the creation of cross‐links between aldehydes and amino groups, thereby increasing tissue stability (11).…”

Section: Discussionmentioning

confidence: 99%

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Glutaraldehyde‐treated Bovine Pericardium: Effects of Lyophilization on Cytotoxicity and Residual Aldehydes

et al. 2003

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This work assesses the effect of lyophilization on the cytotoxicity and residual aldehyde concentration of glutaraldehyde-treated and lyophilized bovine pericardium (group A), comparing it to conventional glutaraldehyde-treated bovine pericardium (group B). Cytotoxicity was measured by incubating a pericardium sample from each group in saline and assessing the eluant's influence on cellular growth. Residual aldehydes were measured by HPLC. Although both groups' eluants exhibited some cytotoxicity, the eluant from group A was less cytotoxic, with a cytotoxicity index (IC50(%)) of 41%. Group B eluants all had marked cytotoxic effects; cell growth was 24.15% of the negative control at the most dilute eluant concentration (6.25%). The mean residual glutaraldehyde level was less in group A than in group B (2.36 +/- 0.11 and 9.90 +/- 3.70 g/l, respectively; n=3, P < 0.05), but residual formaldehyde levels did not differ. These results demonstrate that compared with conventional glutaraldehyde-treated bovine pericardium, lyophilized pericardium is less cytotoxic, with fewer glutaraldehyde residues.

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Section: Discussionmentioning

confidence: 99%

“…Bovine pericardium patches were treated with GA at 0.56%(8) and stored in 4% FA for no less than 3 months. Two sample sets, comprising three patches each, were used.…”

Section: Methodsmentioning

confidence: 99%

Glutaraldehyde‐treated Bovine Pericardium: Effects of Lyophilization on Cytotoxicity and Residual Aldehydes

et al. 2003

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“…Glutaraldehyde preserved bovine pericardium was first used in 1977 to construct a prosthetic heart valve 1 and has found widespread usage as a cardiovascular substitute for intracardiac and extracardiac repairs. Fresh (unfixed) bovine pericardial implants undergo inflammation and partial digestion without mineralization.…”

Section: Introductionmentioning

confidence: 99%

Histologic Evaluation of Explanted Tissue-Engineered Bovine Pericardium (CardioCel)

Prabhu

Armes

Bell

et al. 2017

Seminars in Thoracic and Cardiovascular Surgery

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“…bioprosthesis was first introduced for clinical use in 1971 by lonescu . 1 Since then a number of different pericardia! valves have been manufactured.…”

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confidence: 99%

Long-Term Evaluation of the Carpentier-Edwards Pericardial Valve in the Aortic Position

Perier

Mihaileanu²,

Fabiani³

et al. 1991

Journal of Cardiac Surgery

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From July 1980 to December 1985, 124 patients underwent isolated aortic valve replacement with the Carpentier‐Edwards pericardial bioprosthesis. The mean age of the patients was 64.9 ± 13.1 years. All patients but one (0.7%) were followed for an average of 5.52 ± 0.21 years after the operation and follow‐up totaled to 677 patient‐years. There were six early deaths (30‐day mortality of 4.8%) and 25 late deaths (3.7% ± 0.7% patient‐year). After 9 years the actuarial survival rate was 64% ± 14%. Six patients died of valve‐related deaths (three anticoagulant‐related hemorrhage, one endocarditis, one thromboembolic complication, and one sudden death) for an actuarial rate of 95% ± 5% patients free of valve‐related death at 9 years. Valve‐related complications included five thromboembolic episodes (0.7% ± 0.3% patient‐year), eight anticoagulant‐related hemorrhagic complications (1.2% ± 0.4% patient‐year), and two reoperations (0.3% ± 0.2% patient‐year). After 9 years, freedom from thromboembolic events was 96% ± 4%, that from anticoagulant‐related hemorrhage was 93% ± 5%, and that from reoperation was 98% ± 2%. There was no structural deterioration of the valve. We conclude that the Carpentier‐Edwards pericardial prosthesis has a low incidence of valve‐related complication and mortality within the 9‐year time frame of this study.

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Heart valve replacement with the Ionescu-Shiley pericardial xenograft

Cited by 145 publications

References 17 publications

Glutaraldehyde‐treated Bovine Pericardium: Effects of Lyophilization on Cytotoxicity and Residual Aldehydes

Glutaraldehyde‐treated Bovine Pericardium: Effects of Lyophilization on Cytotoxicity and Residual Aldehydes

Histologic Evaluation of Explanted Tissue-Engineered Bovine Pericardium (CardioCel)

Long-Term Evaluation of the Carpentier-Edwards Pericardial Valve in the Aortic Position

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