Heart-type fatty acid binding protein (hFABP) in the diagnosis of myocardial damage in coronary artery bypass grafting

Petzold, Thomas; Feindt, P.; Sunderdiek, Ulrich; Boeken, Udo; Fischer, Y.; Gams, E.

doi:10.1016/s1010-7940(01)00709-6

Cited by 42 publications

(42 citation statements)

References 23 publications

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“…HFABP mRNA levels are increased by testosterone administration and in response to fasting or exercise in heart, probably due to a higher fatty acids oxidation rate (15). The administration of lipopolysaccharide decreased the expression levels of HFABP in heart (11), and recent work suggests that HFABP protein levels are a good indicator of myocardial damage (12).…”

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confidence: 99%

Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats

Marti

Vaquerizo

Zulet

et al. 2002

J. Physiol. Biochem.

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[69][70][71][72][73][74] 2002 Long-term exposure to hypercaloric high fat diet induced marked tissue fatty acid accumulation and may influence cell function, Previous results in our laboratory showed that uncoupling proteins (UCPs) and fatty acid-binding protein (FABP) gene expression are changed in adipose tissue and skeletal muscle tissue in diet-induced (cafeteria) obese animals. The aim of this study was to examine heart FABP (HFABP) and UCP2 gene expressions in dietary obese rats. Rats fed on a high-fat diet for 65 days had significantly higher fat stores and body weight than control rats. Interestingly, we found that both HFABP and UCP2 mRNA levels were significantly reduced in cafeteria-obese rats when compared to control animals. Moreover, a statistically significant correlation was observed between the two gene expression levels. The down-regulation of heart HFABP and UCP2 parallels the lower lipid utilization which may account for an enhanced fat deposition. It is plausible that these two genes are regulated by the same family of transcription factors.

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confidence: 99%

Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats

Marti

Vaquerizo

Zulet

et al. 2002

J. Physiol. Biochem.

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“…Therefore, the usage of H-FABP as a marker of myocardial damage is problematic (36). The myoglobin/H-FABP ratio in plasma could be used as a solution to this problem (37,38). EST is not a kind of heavy exercise.…”

Section: Discussionmentioning

confidence: 99%

Relationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress testing: an observational study

Arı¹,

Tokaç²,

Alihanoğlu³

et al. 2011

Anadolu Kardiyol Derg

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Objective: Although, there has been great improvement on the diagnosis and early treatment of acute coronary syndromes, especially in terms of myocardial damage biochemical markers, we do not have a specific marker yet, for using the diagnosis of stable coronary artery disease (CAD). This study aimed to evaluate the relationship between CAD and the changes of heart-type fatty acid binding protein (H-FABP) levels before and after exercise stress testing (EST). Methods: A total of 47 patients were enrolled in this observational study. Of 47 patients, 21 had normal coronary anatomy; the remaining 26 patients had coronary lesions over 70% in at least one major coronary artery. All patients performed EST. Along with this, H-FABP levels before EST and at peak exercise, 1 st hour, 3 rd hour (3h), were measured in all patients. Differences among the measurements were evaluated through the Friedman test and Wilcoxon test, and the Bonferroni correction was applied to determine which measurement caused the difference. Results: Contrary to expectations, the means of the H-FABP values measured at particular intervals for each group tended to decline from the basal level to the 3h level. When the difference between the 3h measurement and the basal level was compared in each group, the decreasing was statistically significant in both groups (p<0.05). A statistically significant decrease at the 3h measurement compared to the basal level in the CAD group was more apparent than in the control group (2.790±2.569ng/ml vs. 0.837±2.070ng/ml, p=0.009). Conclusion: We found that H-FABP levels did not increase during EST and contrary to expectation, were inclined to decrease. We thought that decreasing H-FABP levels likely resulted from exercise-induced proteinuria. (Anadolu Kardiyol Derg 2011; 11: 685-91) Key words: Coronary artery disease, heart-type fatty acid binding protein, exercise stress testing 685 ÖZET Amaç: Akut koroner sendrom tanısı ve erken tedavisinde özellikle miyokardiyal hasar belirteçlerinde sağlanan ilerleme ile önemli bir mesafe alınmasına rağmen stabil koroner arter hastalığı (KAH) tanısında kullanılabilecek özel bir markır henüz yoktur. Bu çalışmada egzersiz stres testi (EST) öncesi ve sonrası H-FABP düzeylerindeki değişim ile koroner arter hastalığı arasındaki ilişki araştırılmıştır. Yöntemler: Gözlemsel çalışmamıza en az bir majör koroner arterinde %70 ve üzerinde darlığı olan 26 hasta ve koroner arterleri normal bulunan 21 hasta olmak üzere toplam 47 hasta alındı. Tüm hastalara EST yapıldı. Tüm hastalarda bazal, pik egzersiz, 1. saat ve 3. saatte H-FABP ölçümü yapıldı. Ölçümler arası farka Friedman Testi ile bakıldı, farkın hangi ölçümden kaynaklandığını bulmak için Bonferroni düzeltmeli Wilcoxon Testi kullanıldı. Bulgular: Her bir grupta belirlenen zaman aralığında ölçülen H-FABP değerleri ortalamaları beklenenin aksine bazaldan üçüncü saate azalma eğiliminde idi. Üçüncü saat ile bazal ölçümler arasındaki farklar (fark 3) grup içinde karşılaştırıldığında her iki grupta da azalma anlamlı idi (p<0.05). H...

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“…Although cardiac specific markers such as cardiac troponin I have promising results to discriminate graft related and non-graft-related myocardial injury 12 or 24 hours detection time seems to be too long for emergent myocardial muscle salvage. Therefore prospective randomized trials with new biomarkers for myocardial ischemia such as heart type fatty acid binding proteins or ischemia modified albumin which have recently been reported to detect myocardial ischemia within the first 30 min, may enable early reintervention to restore myocardial perfusion [25][26][27][28].…”

Section: Treatment Optionsmentioning

confidence: 99%

Early graft failure after coronary artery bypass grafting: diagnosis and treatment

Türk

2016

Eur Res J

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Early postoperative graft failure after coronary artery bypass grafting (CABG) is still a significant problem that results in high morbidity and mortality. Different therapeutic options are available to manage this complication which include reoperation, balloon angioplasty, angioplasty along with stenting and conservative medical management. Herein, we review the existing literature in diagnosis and treatment options for overcoming early graft failure immediately following CABG.Eur Res J 2016;2(2):85-92

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Heart-type fatty acid binding protein (hFABP) in the diagnosis of myocardial damage in coronary artery bypass grafting

Cited by 42 publications

References 23 publications

Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats

Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats

Relationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress testing: an observational study

Early graft failure after coronary artery bypass grafting: diagnosis and treatment

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