Heart transplantation in children with markedly elevated pulmonary vascular resistance: Impact of right ventricular failure on outcome

Inhaled nitric oxide in cardiac surgery: Evidence or tradition?

“…24 support similar conclusions from the paediatric heart transplant field, whereby preemptive use of iNO was associated with a decreased incidence of RV failure (87). However, no large prospective studies have been undertaken to confirm such potential.…”

Elevated pre-transplant pulmonary vascular resistance is not associated with mortality in children without congenital heart disease: A multicenter study

“…Most of these studies relied upon single-center populations or public registries, both of which have significant limitations, and utilize analysis methods which may be less accurate when examining a time-varying hazard such as death after transplant (7). While acute right ventricular failure has been proposed as the mechanism of early death in patients with elevated PVRI (11,(14)(15)(16) this relationship is not clear, especially in the modern era of improved treatment of right ventricular failure (4,9,13,14,16,17). Additionally, decreasing the pulmonary vascular resistance pre-transplant, may or may not have an effect upon early mortality (5,18), suggesting that there are more important factors that play a role in early mortality than pulmonary vascular resistance.…”

Transplantation and Mechanical Circulatory Support in Congenital Heart Disease

“…Although several studies have examined PH and posttransplantation outcome, they either purposely did not include patients with CHD or patients with CHD represented a minority of the cohort. [121][122][123][124] Furthermore, these studies included only those who were preselected to undergo transplantation. Therefore, no simple criteria exist to determine who is considered too high risk for orthotopic HTx.…”