Zachary A. Kopp, Jo-Lin Hsieh, Andrew Li, William Wang, Dhelni T. Bhatt, Angela Lee, Sae Yeon Kim, David Fan, Veevek Shah, Emaad Siddiqui, Radhika Ragam, Kristen Park, Dev Ardeshna, Kunwoo Park et al.
Abstract:Downregulation of Rpd3, a homologue of mammalian Histone Deacetylase 1 (HDAC1), extends lifespan in Drosophila melanogaster. Once revealed that long-lived fruit flies exhibit limited cardiac decline, we investigated whether Rpd3 downregulation would improve stress resistance and/or lifespan when targeted in the heart. Contested against three different stressors (oxidation, starvation and heat), heart-specific Rpd3 downregulation significantly enhanced stress resistance in flies. However, these higher levels of…
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