Heart Rate Variability in Young Women with Polycystic Ovary Syndrome

Yildirir, Aylin; Aybar, F.; Kabakçı, Giray; Yaralı́, Hakan; Oto, Ali̇

doi:10.1111/j.1542-474x.2006.00122.x

Cited by 88 publications

(104 citation statements)

References 43 publications

(106 reference statements)

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“…In this study, we found that women with PCOS have reduced cardiac autonomic modulation, as demonstrated in previous studies [3][4][5][6], and ANS fluctuation was reduced in their stimulated ovulatory cycles.…”

Section: Discussionsupporting

confidence: 62%

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The Fluctuation in the Heart Rate Variability Throughout Ovulation Induction Cycle: Is the Case Different in Polycystic Ovary Syndrome?

Üçkuyu¹,

Toprak²,

Çiftçi³

et al. 2013

Gynecol Obstet

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Objective: Women with Polycystic Ovary Syndrome (PCOS) have an increased level of sympathetic nerve activity, which was identified by Heart Rate Variability (HRV). PCOS is a state of ovulatory dysfunction in which there may also develop an abnormal ovary response to gonadotropins. We aimed to compare the changes in the HRV of ovulatory women with PCOS and normoovulatory infertile women throughout their ovulation induction cycles. Methods:We included 38 infertile women in the study, 18 of them oligo/amenorrheic with PCOS and 20 eumenorrheic, who formed the control group. Using power spectral analysis, the HRV indices of the patients were examined in three phases of the ovulation induction cycle with gonadotropins. Results:The HRV indices on the menstrual and mid-luteal period were lower in the PCOS group compared to control group. In the PCOS group, the fluctuation was not observed in the HRV indices throughout the ovulation induction cycle. In the control group, the HRV indices were lower on the mid-luteal period and peri-ovulatory period compared to menstrual period. Conclusion:In anovulatory women with PCOS, HRV fluctuation is different from the normovulatory women throughout the ovulation induction cycles. There might be a link between the disturbed ovulation processes in PCOS and the reduced intra-cycle HRV fluctuation.

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Section: Discussionsupporting

confidence: 62%

“…Although the etiology of PCOS is not exactly known, some have argued that stress and adrenergic activation might be playing a role in its development [2]. It has been demonstrated in previous studies that there is an increase in the sympathetic nerve activity of women with PCOS [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The Fluctuation in the Heart Rate Variability Throughout Ovulation Induction Cycle: Is the Case Different in Polycystic Ovary Syndrome?

Üçkuyu¹,

Toprak²,

Çiftçi³

et al. 2013

Gynecol Obstet

View full text Add to dashboard Cite

show abstract

“…It has been shown that autonomic innervation of the heart may be affected in PCOS with increased sympathetic and decreased parasympathetic components of heart rate variability (39). In a recent study of 75 women with PCOS and matched controls heart rate recovery, a measure of autonomic dysfunction associated with increased mortality was impaired in PCOS after maximal cardiopulmonary exercise testing, and was inversely related to BMI (40).…”

Section: Cvr Markers By Imagingmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Sathyapalan

Atkin²

2012

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) has been associated with increased cardiovascular risk (CVR) markers, but population studies have not clarified whether there is an increase in cardiovascular morbidity and mortality. Four different PCOS phenotypes resulted from the Rotterdam criteria that may differ in their CVR potential, thus introducing further complexity. This has led to studies using surrogate CVR markers including biomarkers in blood and imaging such as flow-mediated vasodilatation. In PCOS, both peripheral and central insulin resistance (IR) have been shown. Weight loss has been shown to improve IR and visceral fat, while insulin sensitizer therapies with metformin or thiazolidinediones improve IR and endothelial dysfunction. IR is also found in non-alcoholic fatty liver disease that in turn is very common in PCOS; studies have suggested that IR may be improved by treatment with metformin and omega-3 fish oils. PCOS patients have a more dyslipidemic phenotype that is worse in 'classical PCOS' associated with a higher CVR. Studies with atorvastatin and simvastatin have reported a decrease in the lipid parameters and an improvement in CVR indices including IR, but it is unclear whether this is due to their lipid-lowering action or a pleiotropic effect of the statin. In this expert opinion review, the relevant literature published during the last 2 years was considered. It focuses on some recent important data that has emerged while also exposing the gaps that remain in our knowledge that need to be addressed.

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“…In the study group, the test was conducted during amenorrheic period 7 . The subjects were asked to report to AFT laboratory at 07.00 hours after overnight fasting.…”

Section: Methodsmentioning

confidence: 99%

“…With this potent comorbid factor, PCOS poses a significant cardiovascular (CV) risk which warrants an early assessment of CV health of patients suffering from this condition 5 . A significant relation between the adverse CV events and autonomic dysfunction has been evidenced from previous studies 6. Few studies have reported CV autonomic involvement in the form of decreased heart rate variability (HRV) and increased sympathetic tone in patients with PCOS 7,8 . But no studies have been conducted till date on the detailed assessment of the reactivity of the sympathetic and parasympathetic division of the autonomic nervous system in PCOS.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Cardiovascular Autonomic Reactivity in Patients With Polycystic Ovary Syndrome

Kuppusamy¹,

Pal²,

Habeebullah³

et al. 2014

J Biol Sci Opin

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Polycystic ovary syndrome (PCOS) in association with obesity poses a significant cardiovascular risk.Autonomic dysfunction is an early marker of cardiovascular risk. The conventional autonomic function tests (CAFT) are standard noninvasive methods of evaluating cardiovascular autonomic re activities.The study was conducted to assess the autonomic reactivity in patients with PCOS using CAFT. Forty newly diagnosed patients with PCOS and 36 age-matched controls were recruited. Body mass index (BMI), waist-hip ratio (WHR), cardiovascular parameters such as basal heart rate (BHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and rate-pressure product (RPP), were measured in them. CAFT assessed were HR and BP response to standing (30:15 ratio), deep breathing (E:I ratio) and isometric handgrip (ΔDBPihg). Association of CAFT reactivity parameters with RPP was assessed by Pearson correlation. Individual association of CAFT reactivity parameters to RPP was assessed by multiple regression analysis. The cases had significantly increased BMI, WHR, BHR, SBP, DBP, MAP and RPP. E:I ratio was decreased and 30:15 ratio and ΔDBPihg were increased in cases.30:15 ratio and ∆DBPihg had a significant positive correlation with RPP and E:I ratio showed negative correlation. Multiple regression analysis demonstrated independent association of RPP with E:I ratio and ∆DBPihg. We conclude that PCOS patients have altered autonomic modulation in the form of increased sympathetic and decreased parasympathetic reactivity. The autonomic dysregulation is linked to myocardial performance in PCOS, which could expose PCOS patients to cardiovascular morbidities.

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Heart Rate Variability in Young Women with Polycystic Ovary Syndrome

Cited by 88 publications

References 43 publications

The Fluctuation in the Heart Rate Variability Throughout Ovulation Induction Cycle: Is the Case Different in Polycystic Ovary Syndrome?

The Fluctuation in the Heart Rate Variability Throughout Ovulation Induction Cycle: Is the Case Different in Polycystic Ovary Syndrome?

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Assessment of Cardiovascular Autonomic Reactivity in Patients With Polycystic Ovary Syndrome

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