Heart rate variability based on risk stratification for type 2 diabetes mellitus

Silva-e-Oliveira, Julia; Amélio, Pâmela Marina; Abranches, Isabela Lopes Laguardia; Damasceno, Dênis Derly; Furtado, Fabianne

doi:10.1590/s1679-45082017ao3888

Cited by 16 publications

(16 citation statements)

References 32 publications

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“…These findings thus collectively imply that the impairment of vagus functional status appears early in the disease course of DM [27]. Silva et al [28] found that lower HRV value was a risk factor for worse outcome among DM patients. Our results showed that sympathetic dysfunction is more significant in DM patients with higher HbA1c level.…”

Section: Discussionmentioning

confidence: 79%

Impact of blood glucose control on sympathetic and vagus nerve functional status in patients with type 2 diabetes mellitus

et al. 2019

Acta Diabetol

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Aims Present study observed the impact of blood glucose control on sympathetic and vagus functional status in type 2 diabetes mellitus (DM) patients through observing the association between glycosylated hemoglobin (HbA1c) level and sympathetic and vagus functional status detected by heart rate recovery (HRR) and heart rate variability (HRV) assessments. Methods Consecutive hospitalized DM patients were divided into well glycemic control group (HbA1c < 7.0%, group WGC, n = 100) and poor glycemic control group (HbA1c ≥ 7.0%, group PGC, n = 100), 100 hospitalized patients without DM served as control group (group C). All subjects underwent blood biochemistry test, treadmill exercise testing and 24-h Holter monitoring. Results HRR and HRV parameters were significantly lower in group WGC and PGC than in group C. Standard deviation of NN intervals (SDNN), standard deviation of all 5-min average NN intervals (SDANN), very low frequency (VLF) values were significantly lower in group PGC than in group WGC. HbA1c level was negatively correlated with HRR1, SDNN, SDANN, VLF, low frequency and high frequency. Logistic regression analysis showed that lower SDNN, SDANN and VLF values were risk factors for high HbA1c levels in DM patients after adjusting for gender, age and beta-blocker use in the model 1, and for gender, age, beta-blocker use, coronary artery disease and hypertension in the model 2. Conclusions Present results indicate that sympathetic and vagal functional status are impaired independent of HbA1c level, while poor glycemic control is related to more significant neurocardiac dysfunction in DM patients.

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Section: Discussionmentioning

confidence: 79%

Impact of blood glucose control on sympathetic and vagus nerve functional status in patients with type 2 diabetes mellitus

et al. 2019

Acta Diabetol

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“…35,36 Yet, many other studies associate DM with the appearance of complications in the cardiovascular system. [37][38][39] Therefore, DM is a potential predictor, knowing that it may cause impairment of the vascular system walls, in addition to carrying other clinical factors such as obesity, physical inactivity, and dyslipidemia. 40,41 The overall diabetic population is denoted at high cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

<p>Impact of Metabolic Syndrome Components in High-Risk Cardiovascular Disease Development in Older Adults</p>

Barbalho

Stival

Lima

et al. 2020

CIA

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Objective: Analyze the influence between the components of metabolic syndrome and the independent risk for cardiovascular disease (CVD) in the elderly. Methods: A descriptive cross-sectional study was carried out with 205 older adults from a primary healthcare unit of the Federal District, Brazil. The cardiovascular risk was determined by the Framingham Risk Score (FRS). The National Cholesterol Evaluation Program for Adult Treatment Panel III 2001 (NCEP-ATP III) criteria were considered to analyze metabolic syndrome (MS) diagnoses. Results: There was a strong association between MS and high cardiovascular risk (OR = 8.86). The univariate analysis main findings revealed that male gender, diabetes, smoking habit, systolic blood pressure, HDL level, high blood glucose, glycated hemoglobin, and LDL level were associated with high cardiovascular risk. FRS increases significantly with the presence of four or more MS components (by 30%, if 4 components are present, and by 40%, if 5 components) when compared with the presence of three or fewer components (P <0.001). A logistic regression analysis of high-risk predictors was described to reduce the effects of confounding and bias factors. Conclusion: The identification of MS associated with high FRS values represents a cascading of adverse effects on the population's aging process.

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“…Furthermore, we found that serum level of cystatin C was higher in DM patients with grade III hypertension than in patients with grade I or II, indicating that serum cystatin C level is correlated with hypertension. Silva-E-Oliveira et al ( 23 ) found that level of serum cystatin C is correlated with the flow-mediated vasodilation. Bhavsar et al ( 24 ) also found that serum cystatin C in patients with pregnancy-induced hypertension syndrome was significantly higher than that in normal control group.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the levels of serum cystatin�C and substance�P in peripheral blood in diabetes mellitus patients complicated with hypertension

Zhu

Gong²,

Luo

et al. 2018

Exp Ther Med

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Correlation between the serum cystatin C and substance P in peripheral blood of diabetes mellitus patients complicated with hypertension was investigated. Diabetes mellitus patients with or without hypertension were selected in No. 215 Hospital of Shaanxi Nuclear Industry from December 2015 to February 2017. There were 60 patients with only hypertension (hypertension control group), 60 patients with only diabetes mellitus (diabetes mellitus control group) and 60 patients with diabetes mellitus combined with hypertension (observation group). Levels of serum cystatin C and substance P in peripheral blood were measured via immunoturbidimetry and enzyme-linked immunosorbent assay, respectively, and the correlation with hypertension was analyzed. The average level of serum cystatin C in the observation group was higher than that of the two control groups (P<0.05). The level of substance P in peripheral blood of the observation group was lower than that of the diabetic control group (P<0.05). The levels of serum cystatin C in patients with grade III hypertension in observation group were higher than those in grades II and I, and the levels of substance P in peripheral blood of patients with grade III hypertension in observation group were lower than those in grades II and I. Systolic pressure of patients in observation group was significantly positively correlated with level of serum cystatin C, but significantly negatively correlated with level of substance P in peripheral blood (P<0.05). Compared with the diabetes mellitus patients, level of serum cystatin C was higher, and level of substance P peripheral blood was lower in diabetes mellitus patients complicated with hypertension. In diabetes mellitus patients, blood pressure was positively correlated with serum cystatin C level, and negatively correlated with substance P level in peripheral blood.

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Heart rate variability based on risk stratification for type 2 diabetes mellitus

Cited by 16 publications

References 32 publications

Impact of blood glucose control on sympathetic and vagus nerve functional status in patients with type 2 diabetes mellitus

Impact of blood glucose control on sympathetic and vagus nerve functional status in patients with type 2 diabetes mellitus

<p>Impact of Metabolic Syndrome Components in High-Risk Cardiovascular Disease Development in Older Adults</p>

Correlation between the levels of serum cystatin�C and substance�P in peripheral blood in diabetes mellitus patients complicated with hypertension

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