Hearing Disorders After Haemophilus influenzae Meningitis: Comparison of Different Drug Regimens

Progress in the Prevention of Hearing Loss in Infants

“…These figures, together with the approximate 4,000 infants born with severe bilateral hearing loss annually in the United States (National Institutes of Deafness and Other Communicative Disorders, 19931, could represent almost one third of all children under 5 years of age who either are born with or acquire severe hearing impairment each year. Antimicrobial Therapy Reports began appearing in the late 1970s questioning the effectiveness of ampicillin (a synthetic penicillin) and chloramphenicol, the antibiotics of choice at the time, in reducing the high frequency of neurologic residuals, particularly sensorineural hearing loss, after Haemophilus influenzae Type b meningitis (Lindberg, 1977;Raivio & Koskiiemi, 1978). Concern over the failure of conventional antibiotic therapy together with reports of the appearance of strains of Hib resistent to ampicillin and/or chloramphenicol prompted searches for alternative therapies; among them, the newer cephalosporin broad spectrum antibiotics (cefuroxime, ceftriaxome, and cefotaxime) resistant to the enzyme which converts penicillin into an inactive product (beta-lactamase).…”

Correlação entre volume coclear residual pós-labirintite ossificante e medidas de impedância dos eletrodos intracocleares em pacientes submetidos à cirurgia de implante coclear

“…Alterações auditivas secundárias à meningite podem ocorrer por três mecanismos diferentes (Raivio;Koskiniemi, 1978): a) labirintite purulenta (conforme disseminação dos mediadores inflamatórios e das bactérias associadas alcançando a orelha interna); b) perineurite do oitavo par craniano (se processo localizado no conduto auditivo interno); c) agressão direta ao núcleo coclear localizado no tronco encefálico ou nas vias auditivas superiores (se processo limitado ao sistema nervoso central).…”