Healthy aging, memory subsystems and regional cerebral oxygen consumption

Eustache, Francis; Rioux, Patrice; Desgranges, Béatrice; Marchal, G; Petit-Taboué, M.C.; Dary, Martine; Lechevalier, B; Baron, Jean‐Claude

doi:10.1016/0028-3932(95)00021-t

Cited by 80 publications

(60 citation statements)

References 54 publications

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“…First, the effect on the second-order common factor may be attributable to activity within the prefrontal cortex, possibly modulated by the level of a neurotransmitter, such as dopamine (e.g., Braver et al, 2001;Li, 2002). Second, the effect on the first-order memory factor might reflect functioning of the hippocampus and medial temporal lobe (e.g., Eustache et al, 1995;Golumb et al, 1994). Third, the effects on the first-order speed factor may be at least partially attributable to age-related degeneration of myelin (e.g., Bartzokis, 2004;Greenwood, 2000) that could impair the effectiveness of communication across different brain regions.…”

Section: Discussionmentioning

confidence: 99%

Localizing age-related individual differences in a hierarchical structure

2004

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Data from 33 separate studies were combined to create an aggregate data set consisting of 16 cognitive variables and 6832 different individuals who ranged between 18 and 95 years of age. Analyses were conducted to determine where in a hierarchical structure of cognitive abilities individual differences associated with age, gender, education, and self-reported health could be localized. The results indicated that each type of individual difference characteristic exhibited a different pattern of influences within the hierarchical structure, and that aging was associated with four statistically distinct influences; negative influences on a second-order common factor and on first-order speed and memory factors, and a positive influence on a first-order vocabulary factor.

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Section: Discussionmentioning

confidence: 99%

Localizing age-related individual differences in a hierarchical structure

2004

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“…In order to limit their number, the regions of interest were selected according to hypotheses drawn from the neuropsychological literature [see Table 1, and also Eustache et al (1995) and Discussion section]. Anatomical location of the cortical and sub-cortical regions of interest (14 per cerebral hemisphere, plus one per cerebellar hemisphere) was carried out on the MRI (or, if unavailable, on the CT-scan, according to Penniello et al, 1995) of each patient (Allain et al, 1993) with reference to the stereotaxic atlas of Talairach and Tournoux (1988).…”

Section: The Regions-of-interest Methodsmentioning

confidence: 99%

“…However, these studies did not focus on the neuronal systems underlying memory impairment in Alzheimer's disease, i.e. the tests used were not targeted in a prospective manner on particular memory systems, while the possible confounding effect of age (Duara et al, 1984;Eustache et al, 1995) was rarely considered. Recent studies (Collette et al, 1997;Grossman et al, 1997) aimed at identifying the cerebral regions underlying memory deficits, but they were each limited to one system only (short-term and semantic memory, respectively).…”

Section: Introductionmentioning

confidence: 99%

The neural substrates of memory systems impairment in Alzheimer's disease. A PET study of resting brain glucose utilization

Desgranges

Baron²,

Sayette³

et al. 1998

Brain

300

183

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“…In healthy subjects, the logic of this cognitive-metabolic approach in AM is based on the variability concerning both cognitive performance (Levine et al, 2002;Piolino et al, 2002Piolino et al, , 2006) and brain functions (Fransson, 2005;Coles et al, 2006). In this context, this approach is particularly potent in middle-aged and old healthy subjects who present an increasing in intersubject variability compared to young subjects (Eustache et al, 1995;Piefke and Fink, 2005;Coles et al, 2006). Moreover, the study of older subjects allows examination of the correlation between resting-state brain measures and thorough cognitive measures of AM for very long retention intervals, some lasting decades.…”

Section: Introductionmentioning

confidence: 99%

Reliving lifelong episodic autobiographical memories via the hippocampus: A correlative resting PET study in healthy middle‐aged subjects

et al. 2008

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We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to relive richly detailed episodic autobiographical memories from five time periods using the Remember/Know procedure. We computed an index of episodicity (number of Remember responses justified by the recall of specific events and details) and an index of retrieval spontaneity, and additionally an index of semanticized memories (number of Know responses). The regional cerebral blood flow (rCBF) was measured in the resting state, with H(2)O(15) as part of an activation PET study. The indexes were correlated with blood flow using volumes of interest in frontotemporal regions, including hippocampus and voxel-wise analyses in SPM. With both analyses, significant correlations were mainly found between the index of episodicity and rCBF in the medial temporal lobe, including hippocampus, across the five time periods (unlike the index of semanticized memories) and between the spontaneity index and rCBF in the prefrontal areas. These results highlight, in healthy subjects, the distinct role of these two structures in AM retrieval and support the view that the hippocampus is needed for reexperiencing detailed episodic memories no matter how old they are.

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Healthy aging, memory subsystems and regional cerebral oxygen consumption

Cited by 80 publications

References 54 publications

Localizing age-related individual differences in a hierarchical structure

Localizing age-related individual differences in a hierarchical structure

The neural substrates of memory systems impairment in Alzheimer's disease. A PET study of resting brain glucose utilization

Reliving lifelong episodic autobiographical memories via the hippocampus: A correlative resting PET study in healthy middle‐aged subjects

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