Healthcare utilization and costs in adults with stable and uncontrolled epilepsy

Cramer, Joyce A.; Wang, Zhixiao J.; Chang, Eunice; Powers, Annette; Copher, Ronda; Cherepanov, Dasha; Broder, Michael S.

doi:10.1016/j.yebeh.2013.09.046

Cited by 134 publications

(116 citation statements)

References 28 publications

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“…The consequence of AEDs nonadherence behavior has been associated with: poor seizure control, increased morbidity and mortality along with increased time of hospitalization, worsened patient outcome, increased health care cost and death (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Associated Factors of Antiepileptic Drugnonadherence Among Epileptic Patients Attending at Out Patient Departement of Dilla University Referral Hospital, Dilla,gedeo,snnpr, Southern Ethiopia

2017

IJBM

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Background: Antiepileptic drugs are effective in the treatment of epilepsy, but poor adherence to medication is major problem to sustained remission and to functional restoration. Poor adherence to treatment is one of many reasons for pharmacological treatment failure and seizure recurrence. Even though there were studies on the magnitude and associated factors of Antiepileptic drugs non-adherence, there is a shortage of published information regarding the prevalence and associated factors of Antiepileptic drugs none-adherence in Ethiopia. Objective: To assess prevalence and associated factors of antiepileptic drug none-adherence among epileptic patients attending at Dilla University Referral Hospital. Methods: Institutional based cross sectional study design was conducted at Dilla University Referral Hospital from March to May, 2016. A total of 265 individuals was selected by simplerandom sampling method and interviewed by using structured questionnaire. 8 itemMorisky Medication Adherence Scalewas used to assess the prevalence of antiepileptic drug non adherence. Data was coded and exported to SPSS version 20 for analysis. Results: The prevalence of Antiepileptic's drug none-adherence in this study was 38. .48, 95%, CI: 0.722,3.035] were found to be significantly associated (p<0.05). Conclusion: The prevalence of antiepileptic drug none-adherence among patients with epilepsy disorder was found 38.1%. Getting medication by payment, did not receive health information about (the illness, duration of treatment, medication side effect), skip dose, on treatment for 2-5 years, and poor social support were found to be the independent predictor of antiepileptic drug none-adherence.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Associated Factors of Antiepileptic Drugnonadherence Among Epileptic Patients Attending at Out Patient Departement of Dilla University Referral Hospital, Dilla,gedeo,snnpr, Southern Ethiopia

2017

IJBM

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“…C omorbid conditions are prevalent in epilepsy and actually exceed the disability caused by seizures themselves (Lin et al 2012); over a lifetime, their diagnosis and treatment more than doubles the overall economic burden of the disorder (Cramer et al 2014). Classically, the term "comorbidity" was introduced by Feinstein to denote cases in which "a distinct additional clinical entity" occurred during the clinical course of a patient presenting with an index disease.…”

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confidence: 99%

Single-Gene Determinants of Epilepsy Comorbidity

Noebels

2015

Cold Spring Harb Perspect Med

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“…Nowadays we have several AEDs with different mechanisms of action, and various double therapy combinations are being studied, trying to find additive, or even supra-additive enhancement of efficacy [3]. Nevertheless, triple therapy continues to be an option [4,5] and in fact it is used in selected cases. Among patients with stable epilepsy, 5 % use a three-AED combination therapy, while among patients with uncontrolled epilepsy the percentage reaches 21 % [5].…”

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confidence: 99%

“…Nevertheless, triple therapy continues to be an option [4,5] and in fact it is used in selected cases. Among patients with stable epilepsy, 5 % use a three-AED combination therapy, while among patients with uncontrolled epilepsy the percentage reaches 21 % [5].…”

mentioning

confidence: 99%

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Antiepileptic polytherapy: clinical outcome after reduction from three to two drugs. Is triple therapy justified?

et al. 2014

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Healthcare utilization and costs in adults with stable and uncontrolled epilepsy

Cited by 134 publications

References 28 publications

Prevalence and Associated Factors of Antiepileptic Drugnonadherence Among Epileptic Patients Attending at Out Patient Departement of Dilla University Referral Hospital, Dilla,gedeo,snnpr, Southern Ethiopia

Prevalence and Associated Factors of Antiepileptic Drugnonadherence Among Epileptic Patients Attending at Out Patient Departement of Dilla University Referral Hospital, Dilla,gedeo,snnpr, Southern Ethiopia

Single-Gene Determinants of Epilepsy Comorbidity

Antiepileptic polytherapy: clinical outcome after reduction from three to two drugs. Is triple therapy justified?

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