Health repercussions of environmental exposure to lead: Methylation perspective

Shiek, Sadiya S; Mani, Monica Shirley; Kabekkodu, Shama Prasada; Dsouza, Herman Sunil

doi:10.1016/j.tox.2021.152927

Cited by 27 publications

(15 citation statements)

References 197 publications

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“…The DOHaD theory is now widely accepted as a very important concept regarding health problems. The number of previous experimental studies on the effects of Pb from the viewpoint of DOHaD is not large and biased toward transcriptomics and epigenetic alterations including DNA methylation status ( Lee et al, 2018 ; Shiek et al, 2021 ), which investigate the cause of but not the result of adverse health effects induced by Pb exposure. In this context, our finding of developmental anomalies at 7 dpf is a new example supporting the DOHaD theory.…”

Section: Discussionmentioning

confidence: 99%

Developmental adverse effects of trace amounts of lead: Evaluation using zebrafish model

Komoike

Matsuoka

2022

Front. Pharmacol.

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Lead (Pb) is widely used as a raw material for various daily necessities in human civilization. However, Pb is a major toxicant and Pb poisoning has long been a global health concern. A large body of evidence has revealed that exposure to Pb causes a variety of adverse health effects. Meanwhile, experimental studies on the developmental effects caused by trace amounts of Pb remain to be fully conducted. Therefore, we aimed to provide direct experimental evidence of the adverse developmental effects of Pb exposure below the occupational regulatory standard concentrations using a zebrafish model. We also attempted to investigate the cellular stress response caused by such a trace amount of Pb at the individual level. Fertilized zebrafish eggs were exposed to 100 ppb Pb from 6 to 72 h post fertilization (hpf), the developmental period included within the mammalian implantation to birth. The embryos exposed to Pb did not show superficially evident morphological alterations or differences in viability compared with the controls until 72 hpf; however, they hatched earlier and were significantly shorter in body length than the controls at 48 and 72 hpf. Larvae that were exposed to Pb until 72 hpf and then cultured until 7 days post fertilization without Pb exhibited edema and inflation defects in the swim bladder. The reactive oxygen species level in the Pb-exposed embryos was similar at 24 hpf, slightly but significantly higher at 48 hpf, and lower than half that of the control at 72 hpf. Accordingly, the expression levels of oxidative stress response-related genes were analyzed, and five out of seven tested genes were upregulated in Pb-exposed embryos at 48 and 72 hpf. In addition, the endoplasmic reticulum (ER) stress related genes were upregulated at 48 hpf. These results indicate that exposure of embryos to trace amounts of Pb induces a transient increase in oxidative- and ER-stresses and results in weak hypotrophy and subsequent abnormalities later in development. Our findings may be key to understanding the total health effects of Pb exposure, and indicate that the zebrafish model is suitable for the investigation of developmental toxicity of pollutants such as Pb.

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Section: Discussionmentioning

confidence: 99%

Developmental adverse effects of trace amounts of lead: Evaluation using zebrafish model

Komoike

Matsuoka

2022

Front. Pharmacol.

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“…Among the three epigenetic modulators, altered DNA methylation causing non communicable diseases such as autism, impaired growth, neurodegenerative, cardiovascular diseases and risk of developing cancer is extensively reported in vivo studies as well as validated in human cohort. [70,110,111] On the other hand, scientific literature pertaining to histone modifications in response to in utero Pb exposure is very sparse and fails to highlight the potential link between Pb exposure in the prenatal and perinatal stages and their effect in developing fetus. Although the evidence is suggestive of link between oxidative stress, inflammation and altered PTHMs in various disease models, contributory role of Pb in pathophysiology of systemic manifestations is far from clear.…”

Section: Pthm a Potential Link Between Pb Exposure And Systemic Disea...mentioning

confidence: 99%

Effect of lead exposure on histone modifications: A review

Kumar,

Anjali,

Sharma

2023

J Biochem & Molecular Tox

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Lead at any levels can result in detrimental health effects affecting various organ systems. These systematic manifestations under Pb exposure and the underlying probable pathophysiological mechanisms have not been elucidated completely. With advancements in molecular research under Pb exposure, epigenetics is one of the emerging field that has opened many possibilities for appreciating the role of Pb exposure in modulating gene expression profiles. In terms of epigenetic alterations reported in Pb toxicity, DNA methylation, and microRNA alterations are extensively explored in both experimental and epidemiological studies, however, the understanding of histone modifications under Pb exposure is still in its infant stage limited to experimental models. In this review, we aim to present a synoptic view of histone modifications explored in relation to Pb exposure attempting to bring out this potential lacunae in research. The scarcity of studies associating histone modifications with Pb toxicity, and the paucity of their validation in human cohort further emphasizes the strong research potential of this field. We summarize the review by presenting our hypotheses regarding the involvement of these histone modification in various diseases modalities associated with Pb toxicity

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“…These changes include methylation, modification of chromatin proteins, and noncoding RNA, which regulates gene expression and regulates transcription. [ 98 ] In the late 1990s, epigenetic changes brought on by As exposure became a major focus of research. Mass and Wang (1997) established that when people were exposed to As, there was hypermethylation of the p53 gene.…”

Section: Epigenetic Changes After As Exposurementioning

confidence: 99%

Arsenic‐induced toxicity and the ameliorative role of antioxidants and natural compounds

Shiek

Sajai

Dsouza

2022

J Biochem & Molecular Tox

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Arsenic (As) poisoning has proven to be a major threat worldwide because of its toxic effects on the human body. As toxicity through drinking water is a global health concern. The toxicity of As is known to affect the liver, kidney, lungs, muscles, cardiovascular system, and nervous system and can even induce diabetes. Further As can cause skin lesions leading to notable diseases in the skin like Bowen's disease.Chronic exposure to As has caused many tragedies in Eastern, and several Southeast Asian and Latin American countries. Long-term exposure to As makes it an immediate threat that should be dealt with as a priority, and one of the ways to handle it may be with the use of antioxidants. In this review, we have discussed the natural and anthropogenic sources of As, its metabolism, pathophysiology, and mechanism of toxicity. Besides, we have also discussed some of the synthetic chelators and the ameliorative role of antioxidants and natural compounds in reducing As toxicity.

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Health repercussions of environmental exposure to lead: Methylation perspective

Cited by 27 publications

References 197 publications

Developmental adverse effects of trace amounts of lead: Evaluation using zebrafish model

Developmental adverse effects of trace amounts of lead: Evaluation using zebrafish model

Effect of lead exposure on histone modifications: A review

Arsenic‐induced toxicity and the ameliorative role of antioxidants and natural compounds

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