Health-related quality of life of patients on antiretroviral treatment in Botswana: A cross-sectional study

Ndubuka, Nnamdi; Lim, Hyun J.; Ehlers, V.J.; Wal, D.M. Van der

doi:10.1017/s1478951516000638

Cited by 7 publications

(12 citation statements)

References 22 publications

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“…HIV patients on ART, who were living in urban residences were 4 times more likely to experience a better QoL as compared to HIV individuals on ART living in rural residences. A similar finding was observed in studies from Jimma Ethiopia, Botswana, Zimbabwe, and Uganda [4,9,14,18,20]. This might be associated with the presence of poor infrastructures, financial limitations as well as social stigma and bias in rural areas.…”

Section: Discussionsupporting

confidence: 82%

“…The World Health Organization (WHO) define QoL as "individuals' insight of their situation in life within the context of the culture and value, in which they live and in reference to their goals, standards, expectations, and concerns" [7,8]. During the past twenty years, QoL has become a significant outcome measure in medical and psychological research, and evaluations of latest treatments, and interventions to enhance healthcare require measurement of QoL [9]. QoL measures are becoming an integral part of patient follow-up, providing valuable feedback from patients' perspective on the disease and associated interventions [3].…”

Section: Participants and Variables Of The Studymentioning

confidence: 99%

See 1 more Smart Citation

Health-related quality of life and associated factors among HIV-positive individuals on antiretroviral therapy at Debre Markos Referral Hospital, Northwest Ethiopia

Koster¹,

Taddele²,

Aderaw³

et al. 2022

hivar

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Introduction: Human immunodeficiency virus (HIV)-positive patients struggle with numerous social problems; they are vulnerable to repeated opportunistic infections that withdraw them from regular work, which further leads to economic problems and reducing their overall quality of life. Therefore, the aim of this study was to assess health-related quality of life (HR-QoL) and associated factors among HIVpositive individuals on antiretroviral therapy at

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Section: Discussionsupporting

confidence: 82%

Section: Participants and Variables Of The Studymentioning

confidence: 99%

Health-related quality of life and associated factors among HIV-positive individuals on antiretroviral therapy at Debre Markos Referral Hospital, Northwest Ethiopia

Koster¹,

Taddele²,

Aderaw³

et al. 2022

hivar

View full text Add to dashboard Cite

show abstract

“…Nevertheless, we noted the rising popularity of WHOQOL‐HIV BREF and EQ‐5D‐3L/EQ‐5D‐5L and declining use of MOS‐HIV. The WHOQOL‐HIV BREF was developed by the World Health Organization to capture quality‐of‐life cross‐culturally in PLHIV and is available in more than 20 languages, hence, its popularity may be explained by its extensive applicability across many cultural contexts [ 29 ]. WHO instruments are also one of the only HRQoL scales incorporating a spirituality domain.…”

Section: Resultsmentioning

confidence: 99%

Use of quality‐of‐life instruments for people living with HIV: a global systematic review and meta‐analysis

Zhang

Peasgood

et al. 2022

J Int AIDS Soc.

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Introduction Due to the effectiveness of combined antiretroviral therapy and its growing availability worldwide, most people living with HIV (PLHIV) have a near‐normal life expectancy. However, PLHIV continue to face various health and social challenges that severely impact their health‐related quality‐of‐life (HRQoL). The UNAIDS Global AIDS Strategy discusses the need to optimize quality‐of‐life, but no guidance was given regarding which instruments were appropriate measures of HRQoL. This study aimed to review and assess the use of HRQoL instruments for PLHIV. Methods We conducted a global systematic review and meta‐analysis, searching five databases for studies published between January 2010 and February 2021 that assessed HRQoL among PLHIV aged 16 years and over. Multivariable regression analyses were performed to identify factors associated with the choice of HRQoL instruments. We examined the domains covered by each instrument. Random‐effects meta‐analysis was conducted to explore the average completion rates of HRQoL instruments. Results and discussion From 714 publications, we identified 65 different HRQoL instruments. The most commonly used instruments were the World Health Organization Quality‐of‐Life‐ HIV Bref (WHOQOL‐HIV BREF)—19%, Medical Outcome Survey‐HIV (MOS‐HIV)—17%, Short Form‐36 (SF‐36)—12%, European Quality‐of‐Life Instrument‐5 Dimension (EQ‐5D)—10%, World Health Organization Quality‐of‐Life Bref (WHOQOL BREF)—8%, Short Form‐12 (SF‐12)—7% and HIV/AIDS Targeted Quality‐of‐Life (HAT‐QOL)—6%. There were greater odds of using HIV‐specific instruments for middle‐ and low‐income countries (than high‐income countries), studies in the Americas and Europe (than Africa) and target population of PLHIV only (than both PLHIV and people without HIV). Domains unique to the HIV‐specific instruments were worries about death, stigma and HIV disclosure. There were no significant differences in completion rates between different HRQoL instruments. The overall pooled completion rate was 95.9% (95% CI: 94.7−97.0, I 2 = 99.2%, p < 0.01); some heterogeneity was explained by country‐income level and study type. Conclusions A wide range of instruments have been used to assess HRQoL in PLHIV, and the choice of instrument might be based on their different characteristics and reason for application. Although completion rates were high, future studies should explore the feasibility of implementing these instruments and the appropriateness of domains covered by each instrument.

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“…Various studies reported that the psychological domain (5.99) [ 27 ], general health functioning (41.35±10.28) [ 28 ], role emotional (41.5±15.1) [ 29 ], environment domain (12.9±2.5) [ 30 ], and energy (60.6±23.3) [ 18 ] had the lowest HRQoL mean score. In Iran, HIV patients had low QoL in all health-related domains [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…This finding discord with other studies conducted elsewhere in the world. Education was significantly correlated with all domains of HRQoL scores [ 30 ], and lower education was responsible for lower HRQoL [ 13 , 25 , 26 ]. Thus, it is not surprising that better educational status will yield good HRQoL as patients who have formal education might have superior knowledge regarding the disease, related opportunistic infections, and the medication, and become adherent [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life and associated factors among people living with human immunodeficiency virus on highly active antiretroviral therapy in North East Ethiopia: Cross-sectional study

et al. 2021

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Introduction HIV/AIDS remains a public health concern affecting millions of people across the world. Although the health-related quality of life (HRQoL) of patients living with HIV has significantly improved after treatment, its chronicity makes the HRQoL uncertain. This study assessed factors associated with the health-related quality of life among people living with HIV/AIDS on HAART in North-East Ethiopia. Methods An institutional-based cross-sectional study was conducted from March to April 2018, and systematic random sampling was used to select 235 participants who were on HAART. HRQoL was assessed using the Medical Outcomes Study HIV Health Survey. Descriptive and multiple linear regression analysis were computed using the statistical package for social sciences version 20. Results The study revealed one-factor structure and had good overall internal consistency (78.5). Over one-third (42.6%; 95% CI; 36.2%, 48.9%) of participants had good HRQoL. The least HRQoL mean score was found for cognitive functioning 32.21(±19.78), followed by social functioning 40.58(±29.8). Factors associated with the overall HRQoL were 25–45 years of age (β = − 3.55, 95% CI;-6.54, -0.55), working in private sector (β = -5.66, 95% CI;-9.43, -1.88), government (β = -4.29, 95% CI;-7.83, -0.75) and self-employment (β = -8.86, 95% CI;-13.50, -4.21), 100–200 (β = − 4.84, 95% CI;-9.04, -0.63) and 201–350 CD4 at the time of diagnosis (β = − 7.45, 95% CI;-11.73, -3.16), 351–500 current CD4 level (β = 8.34, 95% CI;5.55, 11.41), 6–10 years of disease duration (β = -8.28, 95% CI;-12.51, -4.04), WHO stage II (β = -4.78, 95% CI;-8.52, -1.04) and III (β = 3.42, 95% CI;0.06, 6.79) during treatment initiation and not taking of Cotrimoxazole prophylaxis (β = -5.79, 95% CI;-8.34, -3.25). Conclusions High proportion of participants had a poor HRQoL. Routine assessment and appropriate interventions at each visit is recommended to improve HRQoL.

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Health-related quality of life of patients on antiretroviral treatment in Botswana: A cross-sectional study

Abstract: HRQoL assessments can identify and address patients' needs, and it is important that guidelines be developed that will yield improved care to ART patients in Botswana.

Cited by 7 publications

References 22 publications

Health-related quality of life and associated factors among HIV-positive individuals on antiretroviral therapy at Debre Markos Referral Hospital, Northwest Ethiopia

Health-related quality of life and associated factors among HIV-positive individuals on antiretroviral therapy at Debre Markos Referral Hospital, Northwest Ethiopia

Use of quality‐of‐life instruments for people living with HIV: a global systematic review and meta‐analysis

Health-related quality of life and associated factors among people living with human immunodeficiency virus on highly active antiretroviral therapy in North East Ethiopia: Cross-sectional study

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