Health-Related Quality of Life in Long Term Breast Cancer Survivors Treated with Breast Conserving Therapy: Impact of Age at Therapy

Fehlauer, Fabian; Tribius, Silke; Mehnert, Anja; Rades, Dirk

doi:10.1007/s10549-005-2420-2

Cited by 63 publications

(60 citation statements)

References 32 publications

(28 reference statements)

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“…Longitudinal studies have confirmed fatigue as the most prevalent physical effect after breast cancer treatment 40,44,45 . However, these sa women reported that pain and nerve damage were also largely responsible for a decline in quality of life that limited their ability to function at their previous jobs 46 .…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Survivorship and South Asian Women: Understanding about the Follow-Up Care Plan and Perspectives and Preferences for Information Post Treatment

et al. 2013

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be experienced in common with bcss of other ethnic backgrounds, but the present study also suggests the presence of unique cultural nuances such as spiritual and language-specific support resource needs. The results provide direction for designing key content and format of scps, and information about elements of care that can be customized to individual patient needs. KEY WORDSSouth Asian women, breast cancer survivors, survivorship care, social and cultural aspects of cancer, psychosocial and physical functioning, life stage

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Section: Discussionmentioning

confidence: 99%

Breast Cancer Survivorship and South Asian Women: Understanding about the Follow-Up Care Plan and Perspectives and Preferences for Information Post Treatment

et al. 2013

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“…This includes clarifying patterns of physical and psychosocial recovery over time, identifying social backgrounds, clinicopathological and treatment-related factors that influence long-term HRQOL, and identifying areas and persons requiring support in the future. Factors with significant effects on long-term HRQOL after treatment of breast cancer include age [18][19][20][21][22][23][24][25], race [9,25], educational status [19][20][21], income [7,8,13], marriage [11,13,21,24,25], recurrence [9,26], disease period [11,20], surgical procedure [7,19,20], chemotherapy [8,10,11,14,20,24], physical activities [27] and culture [25,28]. In our previous longitudinal prospective study, the factors predicting HRQOL at one year after surgery were mood disturbance, poor body image, lower income and positive axillary nodes one month after surgery [17].…”

Section: Introductionmentioning

confidence: 99%

“…As described above, the improvement of overall HRQOL after surgery for breast cancer is generally dependent on the time from diagnosis to treatment, so evaluation at this point is very important when assessing HRQOL [8,22,23]. Social and clinicopathological factors that have significant effects on HRQOL may differ at different time points, and therefore accurate evaluation of HRQOL requires prospective studies.…”

Section: Introductionmentioning

confidence: 99%

Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery

Taira

Shimozuma

Shiroiwa

et al. 2011

Breast Cancer Res Treat

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Provision of social support and rehabilitation for patients with physical, mental and functional problems after cancer treatment is important for long-term health-related quality of life (HRQOL). Effective use of human and financial healthcare resources requires identification of patients requiring rehabilitation. The objectives of the current study were to clarify the patterns of physical and psychosocial recovery over time, to evaluate the associations among baseline variables, treatment-related factors and HRQOL at 6 months, 1 and 2 years after breast cancer surgery, and to identify the significant factors predicting HRQOL at each point. A multicenter longitudinal study was performed to evaluate physical conditions, anxiety, depression and HRQOL at one month (baseline), 6 months, and 1 and 2 years after surgery in 196 patients (mean age: 53.3 years old) with early breast cancer and no postoperative recurrence. Physical conditions were evaluated using a patient-reported symptom checklist. HRQOL was rated using the Functional Assessment of Cancer Treatment scale-General (FACT-G) and the Breast Cancer subscale (FACT-B). Anxiety and depression were rated using the Hospital Anxiety and Depression Scale (HADS).More than 50% of patients had local problems of "tightness", "arm weakness" and "arm lymphedema", and systemic problems of "reduced energy, fatigue, and general weakness" postoperatively. The HRQOL score significantly improved one year after surgery, and scores for physical, emotional and functional well-being also increased with time, whereas the score for social well-being was highest at baseline and decreased with time. Depression and anxiety significantly improved with time. Concomitant disease, marital status and the presence of a partner, anxiety and depression at baseline, pathological lymph node involvement, and adjuvant intravenous chemotherapy were significant factors predicting FACT-G scores at 6 months and 1 and 2 years after surgery. Depression at baseline was a strong predictor of HRQOL up to 2 years after surgery. These results suggest that physical rehabilitation is required for tightness and lymphedema to improve long-term postoperative physical function. A further study of psychosocial interventions is required to improve depression and social well-being after breast cancer surgery.

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“…A influência da idade sobre a reação psicológica ao diagnóstico e ao tratamento antineoplásico remete-nos ao conceito de QV, uma vez que essa reação representa, ao menos parcialmente, o grau de amadurecimento em que a mulher se encontra. Além do impacto psicológi-co, mulheres jovens referem mais dificuldades econômicas 9,10 e maior número de dias perdidos no trabalho 24 . Em recente avaliação de mulheres com média de idade de 43 anos e de tempo de diagnóstico de aproximadamente dois anos, a ausência ao trabalho associou-se negativamente à QV 24 .…”

Section: Idade Ao Diagnósticounclassified

“…Esse quadro pode contribuir para uma percepção negativa da qualidade de vida (QV) 2 . Outros aspectos que podem comprometer a QV de mulheres com câncer de mama relacionamse à diminuição da mobilidade e linfedema do membro superior 6 , uso de quimioterapia 7 , sintomas vasomotores, secura vaginal, disfunções sexuais 8 e dificuldades econômicas 9,10 . A presença de ondas de calor pode comprometer a qualidade e a duração do sono, com conseqüente piora da fadiga 11 e dos sintomas depressivos 4 .…”

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Qualidade de vida de mulheres com câncer de mama

Conde¹,

Pinto‐Neto²,

Júnior³

et al. 2006

Rev. Bras. Ginecol. Obstet.

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RESUMOO câncer de mama é uma das neoplasias mais comuns entre mulheres. O diagnóstico e a terapia antineoplásica determinam repercussões sociais, econômicas, físicas, emocionais/psicológicas e sexuais. Os principais parâmetros empregados na avaliação dos resultados da terapia antineoplásica são a sobrevida livre de doença e a sobrevida global. Mais recentemente, a qualidade de vida (QV) tem sido considerada mais um desses parâmetros. Não existe consenso quanto à definição de QV. Porém, a maioria das definições contempla os aspectos multidimensional e subjetivo da QV. A identificação dos fatores relacionados à QV e a compreensão da forma como esses fatores contribuem para a percepção da QV são motivos de discussão, uma vez que o conceito de QV está diretamente relacionado ao contexto sociocultural em que o indivíduo está inserido. A idade ao diagnóstico, uso de quimioterapia, tipo de cirurgia, sintomas climatéricos, relacionamento conjugal e sexualidade são alguns fatores associados à QV de mulheres com câncer de mama. A QV associada a diferentes terapias antineoplásicas pode auxiliar pacientes e médicos na escolha da melhor modalidade terapêutica. Nesse sentido, o presente artigo revisa diversos aspectos da QV de mulheres com câncer de mama, apresentando e discutindo o estado atual do conhecimento sobre o tema. PALAVRAS-CHAVE: Neoplasias mamárias; Qualidade de vida; Sintomas climatéricos ABSTRACTBreast cancer is one of the most common malignancies among women. Its diagnosis and treatment have social, economic, physical, emotional/psychological and sexual repercussions. The main parameters used to assess the results of anticancer therapy are disease-free survival and overall survival. More recently, quality of life (QOL) has been considered an additional parameter. No consensus exists about the definition of QOL. However, most definitions take into account multidimensional and subjective aspects of QOL. The identification of factors related to QOL and comprehension of how these factors contribute to the perception of QOL are reasons for debate, since the concept of QOL is directly related to the social and cultural context in which the individual is inserted. Age at diagnosis, chemotherapy, type of surgery, climacteric symptoms, relationship between the couple, and sexuality are several factors associated with QOL in women with breast cancer. QOL associated with different antineoplastic therapies may help patients and physicians choose the best therapeutic modality. Towards this end, the current article addresses various aspects of QOL of breast cancer women, and presents the state-ofthe-art knowledge on the topic. KEYWORDS:

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Health-Related Quality of Life in Long Term Breast Cancer Survivors Treated with Breast Conserving Therapy: Impact of Age at Therapy

Cited by 63 publications

References 32 publications

Breast Cancer Survivorship and South Asian Women: Understanding about the Follow-Up Care Plan and Perspectives and Preferences for Information Post Treatment

Breast Cancer Survivorship and South Asian Women: Understanding about the Follow-Up Care Plan and Perspectives and Preferences for Information Post Treatment

Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery

Qualidade de vida de mulheres com câncer de mama

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