Health-related quality of life in patients with multiple myeloma participating in a multidisciplinary rehabilitation program

Nielsen, Lene Kongsgaard; Larsen, Rikke Faebo; Jarlbæk, Lene; Möller, Sören; Jespersen, Eva

doi:10.1007/s00277-020-04356-0

Cited by 9 publications

(17 citation statements)

References 60 publications

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“…In this study, worrying (a core symptom of MM patients with chemotherapy) had the most effect on other symptoms. A total of 54.1% of the participants in our study experienced worrying; this prevalence was higher than in previous studies [ 15 ]. According to the Symptom Experience Mould (SEM), personal and clinical characteristics have an effect on MM patients’ illness perception, and compared to non-chemotherapy patients, worrying includes not only worry about the disease, but also about the effectiveness of the chemotherapy and financial pressure [ 42 ].…”

Section: Discussioncontrasting

confidence: 67%

“…Moreover, MM patients suffer from various psychological symptoms due to the combination of the disease and the adverse effects of chemotherapy. Indeed, approximately 25% of MM patients reportedly suffer from anxiety and depression [ 15 ]. Uncertainty is a common psychological problem due to a lack of information about fear of the disease [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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The core symptom in multiple myeloma patients undergoing chemotherapy: a network analysis

Zeng

Huang

Liu

et al. 2023

Support Care Cancer

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Background During chemotherapy for multiple myeloma, symptoms include those related to the disease, as well as adverse effects of the treatment. Few studies have explored the relationships between these symptoms. Network analysis could identify the core symptom in the symptom network. Objective The aim of this study was to explore the core symptom in multiple myeloma patients undergoing chemotherapy. Methods This was a cross-sectional study in which sequential sampling was used to recruit 177 participants from Hunan, China. Demographic and clinical characteristics were surveyed using a self-developed instrument. The symptoms of chemotherapy-treated multiple myeloma, including pain, fatigue, worry, nausea, and vomiting, were measured using a questionnaire with good reliability and validity. The mean ± SD, frequency, and percentages were used as descriptive statistics. Network analysis was used to estimate the correlation between symptoms. Results The results showed that 70% of multiple myeloma patients using chemotherapy exhibited pain. In the network analysis, worrying was the dominant symptom, and the strongest relationship was between nausea and vomiting in chemotherapy-treated multiple myeloma patients’ symptoms. Conclusion Worrying is the core symptom of multiple myeloma patients. Interventions could be most effective if there is a symptom management focus on worrying when providing care to chemotherapy-treated multiple myeloma patients. Nausea combined with vomiting could be better managed, which would decrease the cost of health care. Understanding the relationship between the symptoms of multiple myeloma patients undergoing chemotherapy is beneficial for precise symptom management. Implications for practice Nurses and health care teams should be a priority to intervene in the worrying for chemotherapy-treated multiple myeloma patients to maximize the effectiveness of an intervention. Except, nausea and vomiting should be managed together in a clinical setting. Supplementary Information The online version contains supplementary material available at 10.1007/s00520-023-07759-7.

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Section: Discussioncontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

The core symptom in multiple myeloma patients undergoing chemotherapy: a network analysis

Zeng

Huang

Liu

et al. 2023

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“…In addition, the effect of PT on health-related quality of life was not examined in this study. A recent previous study reported that there was no change in health-related quality of life before and after the 12-week multidisciplinary rehabilitation program in MM patients 17) . In the future, it is necessary to study more such cases and verify the safety and effectiveness of PT including health-related quality of life in patients with MM.…”

Section: Discussionmentioning

confidence: 91%

Physical therapy for multiple myeloma patients with severely hindered daily living activities due to bone lesions: a report of two cases

Jinbo¹,

Fujita

Kasahara³

et al. 2021

J Phys Ther Sci

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Physical therapy for patients with multiple myeloma requires appropriate exercise intensity and risk management due to osteolytic lesions. However, the optimal strategy for setting exercise intensity remains unclear. We report cases in which physical therapy was performed using the Borg scale and the Common Terminology Criteria for Adverse Events v4.0 as indicators of improvement in the performance of activities of daily living without causing adverse events. [Participants and Methods] Two patients with multiple myeloma, whose performance status was 4, underwent resistance training of the upper and lower limbs and activities of daily living practice in stages according to their functional status. Each exercise was performed for 20 to 40 minutes twice a day for 6 days a week. The exercise intensity was set to 13 on the Borg scale as a guide, and the allowable bone pain was up to Grade 1 according to Common Terminology Criteria for Adverse Events v4.0. [Results] No adverse events occurred in either patient, and the performance status improved to 1 or 2. Subsequently, autologous peripheral hematopoietic stem cell transplantation was performed. [Conclusion] Physical therapy with exercise intensity set to 13 on the Borg scale and Grade 1 per Common Terminology Criteria for Adverse Events v4.0 may safely improve the performance of activities of daily living of patients with multiple myeloma.

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“…Furthermore, MM patients suffer from psychological distress due to the combination of the disease and the adverse effects of chemotherapy. The study showed that one-quarter of MM patients experience the anxiety and depression (Nielsen et al, 2021).…”

Section: Backg Rou N Dmentioning

confidence: 99%

Multiple myeloma patients undergoing chemotherapy: Which symptom clusters impact quality of life?

Zeng

Huang

Chen

et al. 2023

Journal of Clinical Nursing

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Aims and ObjectivesTo identify symptom clusters and examine their association with health‐related quality of life.BackgroundMultiple myeloma patients undergoing chemotherapy suffer from disease symptoms and adverse effects during the course of the disease. However, single symptom management has little effect, and symptom management for these patients remains challenging. Symptom clusters open a new perspective and provide important clues for symptom management.DesignA cross‐sectional study.MethodParticipants were invited to complete the Chinese version of the Memorial Symptom Assessment Scale and Quality of Life Questionnaire‐core 30. Appropriate indicators were used for descriptive statistics. Principal component analysis was used to identify symptom clusters. Associations between symptom clusters and quality of life were examined with Pearson correlation coefficients, Pearson correlation matrix and multiple linear regression. This study was reported following the STROBE checklist.ResultsA total of 177 participants were recruited from seven hospitals in this study. We identified self‐image disorder, psychological, gastrointestinal, neurological, somatic and pain symptom clusters in multiple myeloma patients with chemotherapy. Approximately 97.65% of patients suffer from multiple symptom clusters. The pain, psychological and gastrointestinal symptom clusters have negatively influence on health‐related quality of life. The strongest association was found with the pain symptom cluster.ConclusionMost of multiple myeloma patients suffer from multiple symptom clusters. When improving the multiple myeloma patients' health‐related quality of life, the clinical staff should prioritise relieving the pain symptom cluster.Relevance to Clinical PracticeWhen multiple myeloma patients undergoing chemotherapy suffer from multiple symptom clusters, nurses should prioritise relieving the pain symptom cluster to improve their health‐related quality of life. When drawing up and providing interventions, nurses should focus on the correlation among symptoms rather than single symptom. By relieving one symptom in a given cluster, other symptoms within the same symptom cluster may also be relieved.

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Health-related quality of life in patients with multiple myeloma participating in a multidisciplinary rehabilitation program

Cited by 9 publications

References 60 publications

The core symptom in multiple myeloma patients undergoing chemotherapy: a network analysis

The core symptom in multiple myeloma patients undergoing chemotherapy: a network analysis

Physical therapy for multiple myeloma patients with severely hindered daily living activities due to bone lesions: a report of two cases

Multiple myeloma patients undergoing chemotherapy: Which symptom clusters impact quality of life?

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