Health‐Promoting Proteins and Peptides in Colostrum and Whey

Korhonen, Hannu J. T.

doi:10.1002/9780813811048.ch11

Cited by 2 publications

(1 citation statement)

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“…Milk proteins, being a rich source of bioactive compounds, have been extensively studied and used for the production of health-promoting functional foods ( Korhonen, 2009 ). In particular, the minor proteins that naturally occur in the whey fraction, such as immunoglobulins, lactoferrin, lactoperoxidase, and growth factors, have received considerable commercial and scientific interest ( Korhonen, 2010 ). For example, lactoferrin supplements are widely considered beneficial due to their antimicrobial, antioxidative, and immunomodulatory properties ( Superti, 2020 ).…”

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confidence: 99%

A bioactive bovine whey protein extract improves intestinal barrier function in vitro

Ulluwishewa

Mullaney²,

Adam³

et al. 2022

JDS Communications

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Graphical Abstract Summary: The human intestinal barrier plays an important role in health and disease. Individual whey proteins, such as lactoferrin, that are separated out from the whey, have been shown to improve intestinal barrier function. We hypothesized that the combination of whey proteins that naturally co-occur in milk could exert greater effects on intestinal barrier than lactoferrin alone. In this study we utilized a novel bioactive whey protein (BWP) extract containing all whey proteins in bovine milk with an isoelectric point (pI) >6.8. In support of the hypothesis, our data showed that the BWP extract, but not lactoferrin, (1) enhanced barrier integrity in healthy intestinal epithelial monolayers in vitro, and (2) protected against immune-mediated barrier dysfunction in an in vitro model of the intestinal epithelium. Future studies that consider the natural co-occurrence of bioactive proteins and their synergistic properties could aid in the development of improved dairy-based solutions for health.

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confidence: 99%