Health from the Hive: Propolis as an Adjuvant in the Treatment of Chronic Periodontitis - A Clinicomicrobiologic Study

Abstract

Objectives: This study was aimed at the clinical and microbiological evaluation of the efficacy of subgingivally delivered Indian propolis extract as an adjunct to scaling and root planing (SRP) in the treatment of periodontitis.

Effectiveness of Propolis in the Treatment of Periodontal Disease: Updated Systematic Review with Meta-Analysis

“…After this, three more were removed for different reasons: one because it was a review/commentary [ 29 ], one that tested the efficacy of propolis in reducing chemotherapy-induced oral mucositis [ 30 ] and another [ 31 ] because it was study of equivalence conducted on induced gingivitis. This left a total of 13 studies: eight randomized clinical trials to be included in the meta-analysis [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ] and five non-randomized studies [ 32 , 33 , 34 , 35 , 36 ] ( Figure 1 , flowchart).…”

“…While the possibility of performing a quantitative analysis of the different parameters measured in the studies was considered, it was only possible to carry out the meta-analysis of probing depth assessment. Regarding the rest of the parameters assessed in the studies, the Oral Hygiene Index (OHI) was evaluated in 2 of the studies [ 24 , 25 ] and the Gingival Index (GI) in another 2 [ 25 , 28 ]. Although gingival bleeding was measured in most of the studies, it was tested using different indices depending on the study, which created a disparity of clinical criteria for assessment and precluded the unification of data [ 21 , 22 , 23 , 26 , 27 , 28 ].…”

“…Regarding the rest of the parameters assessed in the studies, the Oral Hygiene Index (OHI) was evaluated in 2 of the studies [ 24 , 25 ] and the Gingival Index (GI) in another 2 [ 25 , 28 ]. Although gingival bleeding was measured in most of the studies, it was tested using different indices depending on the study, which created a disparity of clinical criteria for assessment and precluded the unification of data [ 21 , 22 , 23 , 26 , 27 , 28 ]. As for plaque control, 4 studies tested it using the Plaque Index (PI) [ 23 , 24 , 25 , 26 ], although 2 of them [ 25 , 26 ] did not provide numerical data.…”

“…As for plaque control, 4 studies tested it using the Plaque Index (PI) [ 23 , 24 , 25 , 26 ], although 2 of them [ 25 , 26 ] did not provide numerical data. Concerning clinical attachment level, although it was measured in 3 of the studies [ 21 , 22 , 28 ], that by Sparabombe and colleagues [ 22 ] did not explain the measurement criterion, which means that it was discordant with the measurement units used in the other 2 studies. Because of this, it was determined that the only parameter that was tested with unity of criterion among the studies selected was probing pocket depth (PPD), measured in mm and examined in 6 of the 8 studies selected for the meta-analysis [ 21 , 22 , 23 , 25 , 26 , 28 ].…”

Review of modern herbal preparations used in treatment of inflammatory periodontal diseases

“…В нескольких зарубежных и отечественных исследованиях были зафиксированы биоцидные функции прополиса, в том числе антибактериальные, противогрибковые, антипротозойные, противовирусные, противоопухолевые, иммуномодулирующие и противовоспалительные. Исследования продемонстрировали антимикробную активность экстрактов прополиса против 6 устойчивых к метициллину штаммов Staphylococcus spp., исследования in vitro и in vivo показали активность прополиса про-тив трех пародонтальных патогенов Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn) [23]. В ходе экспериментального исследования на беспородных белых крысах, целью которого было изучение противовоспалительных и регенераторных свойств стоматологического геля на основе растительных компонентов, глюкозамина гидрохлорида и димексида, сока крапивы двудомной и сока каланхоэ, было установлено, что он оказывает противоотечное действие, ускоряет регенерацию тканей, метаболические и репаративные процессы в различных структурах соединительнотканного происхождения [24].…”