This article describes 3 distinct ethnocultural male-to-female transgender communities in New York City: the low-income African American/Black1 and Latina(o) House Ball community; lowincome, often undocumented immigrant Asian sex workers; and middle-class White crossdressers. These communities are highly socially isolated from each other and are more connected to their ethnocultural contexts than to an abstract and shared transgender identity. Whereas previous research either has viewed male-to-female transgender people as one monolithic group or has separated them into abstract racial categories unconnected to their communities and lifestyles, this article positions them within specific social networks, cultures, neighborhoods, and lifestyles. With regard to HIV vulnerabilities, violence, and rape, House Ball community members seemed to engage in the riskiest form of survival sex work, whereas Asian sex workers seemed to engage in moderate-risk survival sex work. White cross-dressers seemed to engage in very low-risk recreational sex work.2 Keywords sex work; House Ball community; Asian immigrants; social networks; ethnocultural community contexts; transgender This article charts new territory by mapping ethnocultural communities and connecting HIV risk behaviors within a nexus of racial, ethnic, cultural, social, and economic factors. Findings from our study of three ethno-cultural transgender communities demonstrate the fundamental roles of economics and marginalization in determining identities and HIV risk behaviors.Male-to-female (MTF) transgender people make up a population that is especially hidden, difficult to reach, and marginalized from the general population