Health and the use of health care services in 5‐year‐old very‐low‐birth‐weight infants

Rautava, Liisi; Häkkinen, Unto; Korvenranta, Emmi; Andersson, Sture; Gissler, Mika; Hallman, Mikko; Korvenranta, Heikki; Leipälä, Jaana; Peltola, Mikko; Tammela, Outi; Lehtonen, Liisa

doi:10.1111/j.1651-2227.2010.01737.x

Cited by 21 publications

(18 citation statements)

References 34 publications

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“…However, visual outcome varied according to birth hospital level [15]. In our data, the time of birth or the birth hospital level were not associated with the quality of life at age 5 or the quality-adjusted life-years [16], the use of health care services, or with subsequent prematurity-related morbidity [17]. Although it is essential to know how the organisation of the care during the perinatal period and early infancy affect the long-term outcome of children born very preterm, there are, to our knowledge, no studies on the effects of the time of birth or birth hospital region on the development or behaviour of this patient group.…”

Section: Introductionmentioning

confidence: 65%

Development and behaviour of 5-year-old very low birthweight infants

Rautava

Andersson

Gissler

et al. 2010

Eur Child Adolesc Psychiatry

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The place and time of birth influence the mortality of premature infants. We studied the effect of prematurity, time of birth, birth hospital level and district on the development and behaviour in a national cohort of 5-year-old Finnish very low birthweight infants (VLBWI). All surviving VLBWI (gestational age \32 weeks or birthweight B1,500 g) born in 2001-2002 in level II or III hospitals in Finland and full-term controls were included. The parents of 588 (64%) VLBWI and 176 (46%) controls returned the Five to Fifteen questionnaire (FTF) on the development and behaviour of their 5-year-old children. The questionnaire scores were linked to data from the National Medical Birth Register, the Hospital Discharge Register, the Register of Congenital Malformations and the Cause of Death Register. VLBWI had lower developmental and behavioural scores compared to the controls in all FTF domains. In VLBWI, the scores were less optimal, the lower the gestational age was. The time of birth, birth hospital level and district were not associated with the developmental and behavioural scores in VLBWI. In conclusion, short duration of pregnancy adversely influences development and behaviour in VLBWI. Despite differences previously demonstrated in mortality related to time and place of birth, there were no differences in developmental and behavioural scores in VLBWI according to the time of birth, birth hospital level or district. Thus, the survival advantage in level III hospitals seems not to be gained at the expense of behavioural or developmental problems.

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Section: Introductionmentioning

confidence: 65%

Development and behaviour of 5-year-old very low birthweight infants

Rautava

Andersson

Gissler

et al. 2010

Eur Child Adolesc Psychiatry

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“…Many such factors have also been linked to the development of wheezing disorders [40],[44],[67]. Through interference with the foetus's natural environment during critical windows of development, the processes underlying preterm birth challenge the developmental plasticity of the lungs and airways [1],[4],[43]. Common antecedents of preterm birth such as inflammation, maternal smoking, metabolic derangement, hypoxia, and growth restriction have well-recognised adverse effects on lung maturation and structure, T cell polarisation and development, and airway reactivity [4],[31],[67]–[69].…”

Section: Discussionmentioning

confidence: 99%

Preterm Birth and Childhood Wheezing Disorders: A Systematic Review and Meta-Analysis

et al. 2014

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“…34,35 This is further aggravated by the fact that premature infants are at high-risk of recurrent hospitalization due to lower respiratory tract infections, as well as chronic pulmonary symptoms. 36 Moreover, although severely premature children have a high incidence of hospitalizations in the first few years of life, 37,38 there is also evidence than these children need more respiratory health care services later in childhood. 37,38 This may in part be due to other co-morbidities associated with prematurity such as neurological impairment, artificial airways, and respiratory support that result in high care resource utilization at least during the first 5 years of life.…”

Section: Discussionmentioning

confidence: 99%

“…36 Moreover, although severely premature children have a high incidence of hospitalizations in the first few years of life, 37,38 there is also evidence than these children need more respiratory health care services later in childhood. 37,38 This may in part be due to other co-morbidities associated with prematurity such as neurological impairment, artificial airways, and respiratory support that result in high care resource utilization at least during the first 5 years of life. 31 Accordingly, our current data demonstrates that there is an association between prematurity and severe HMPV infection during the first 5 years of life and thus provide additional support for the potential use of preventive measures for HMPV infected children with history of prematurity to ameliorate morbidity and mortality in this vulnerable population through childhood.…”

Section: Discussionmentioning

confidence: 99%

Human Metapneumovirus Infection is Associated with Severe Respiratory Disease in Preschool Children with History of Prematurity

Pancham

Sami

Pérez

et al. 2016

Pediatrics & Neonatology

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Rationale Human metapneumovirus (HMPV) is a recently discovered respiratory pathogen of the family Paramyxoviridae, the same of Respiratory Syncytial Virus (RSV). Premature children are at high risk of severe RSV infections, but it is unclear whether HMPV infection is more severe in hospitalized children with history of severe prematurity. Methods We conducted a retrospective analysis of the clinical respiratory presentation of all PCR-confirmed HMPV infections in preschool age children (≤5 yrs.) with and without history of severe prematurity (<32 weeks gestation). Respiratory distress scores were developed to examine the clinical severity of HMPV infections. Demographic and clinical variables were obtained from reviewing electronic medical records (EMR). Results A total of 571 pre-school children were identified by PCR-confirmed viral respiratory tract infection during the study period. HMPV was identified as a causative organism in 63 cases (11%). Fifty–eight (n=58) preschool age children with HMPV infection were included in this study after excluding those with significant co-morbidities. Our data demonstrated that 32.7% of children admitted with HMPV had history of severe prematurity. Preschool children with history of prematurity had more severe HMPV disease as illustrated by longer hospitalizations, new or increased need for supplemental O2, and higher severity scores independently of age, ethnicity and history of asthma. Conclusion Our study suggests that HMPV infection causes significant disease burden among preschool children with history of prematurity leading to severe respiratory infections and increasing health care resource utilization due to prolonged hospitalizations.

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Health and the use of health care services in 5‐year‐old very‐low‐birth‐weight infants

Abstract: Although morbidity and the use of health care services were increased in the surviving VLBWI, the average use of services was relatively small at age 5. In surviving VLBWI, the time of birth and the birth hospital level did not affect morbidity or the use of services.

Cited by 21 publications

References 34 publications

Development and behaviour of 5-year-old very low birthweight infants

Development and behaviour of 5-year-old very low birthweight infants

Preterm Birth and Childhood Wheezing Disorders: A Systematic Review and Meta-Analysis

Human Metapneumovirus Infection is Associated with Severe Respiratory Disease in Preschool Children with History of Prematurity

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