Head movement compensation in real-time magnetoencephalographic recordings

Little, Graham; Boe, Shaun G.; Bardouille, Timothy

doi:10.1016/j.mex.2014.10.008

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…Various approaches such as real-time source estimation are described that can be taken into account in future work now we have demonstrated that patients with chronic lung disease can tolerate the procedures and that useful data are possible. 37 38 Other methods of neural activity measurement such as EEG, for which head movement would not be an issue, should also be explored in future study in this area.…”

Section: Discussionmentioning

confidence: 99%

Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: a feasibility pilot

et al. 2015

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ObjectivesNeuroimaging in chronic breathlessness is challenging. The study objective was to test the feasibility of magnetoencephalography (MEG) for functional neuroimaging of people with chronic breathlessness.DesignFeasibility pilot study.SettingRespiratory clinic out-patients.Participants8 patients (mean age=62; (range 47–83); 4 men) with chronic non-malignant lung disease; modified MRC breathlessness score ≥3 (median mMRC=4), intensity of exercise-induced breathlessness >3/10; no contraindication to MRI scanning.Methods and measures4 MEG scans were conducted for each participant: (1) at rest (5 mins), (2) postseated leg exercise-induced breathlessness during recovery (10 mins). Recovery scans (2) were conducted with/without facial airflow in random order; both scans were repeated 1 h later. Participants rated breathlessness intensity (0–10 Numerical Rating Scale (NRS)) at baseline, maximal exertion and every minute during recovery, and rated acceptability of study procedures at the end of the study (0–10 NRS). A structural MRI scan was conducted for MEG coregistration and source-space analyses. Rest data were compared with data from healthy volunteers (N=6; 5 men; mean age=30.7 years±3.9 years).ResultsExercises and MEG scanning were acceptable to all participants; 7/8 completed the MRI scans. Maximum breathlessness intensity was induced by 5 min’ exercise. The same level was induced for repeat scans (median=8; IQR=7–8). All recovered to baseline by 10 min. Time-frequency profiles of data from the first and last 3 min were analysed in MEG source space based on breathlessness location estimates. Source localisation was performed, but anatomical source inference was limited to the level of the lobe. Differences in areas of activity were seen: during recovery scans; with and without airflow; and between participants/normal volunteers at rest.ConclusionsMEG is a feasible method to investigate exercise-induced breathlessness in people breathless with chronic lung disease, and able to identify neural activity related to changes in breathlessness.

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Section: Discussionmentioning

confidence: 99%

Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: a feasibility pilot

et al. 2015

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“…3 ). However, online correction for head movement could potentially eliminate the need to recalibrate and has been demonstrated as feasible [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

MEG-based neurofeedback for hand rehabilitation

Foldes

Weber

Collinger

2015

J NeuroEngineering Rehabil

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BackgroundProviding neurofeedback (NF) of motor-related brain activity in a biologically-relevant and intuitive way could maximize the utility of a brain-computer interface (BCI) for promoting therapeutic plasticity. We present a BCI capable of providing intuitive and direct control of a video-based grasp.MethodsUtilizing magnetoencephalography’s (MEG) high temporal and spatial resolution, we recorded sensorimotor rhythms (SMR) that were modulated by grasp or rest intentions. SMR modulation controlled the grasp aperture of a stop motion video of a human hand. The displayed hand grasp position was driven incrementally towards a closed or opened state and subjects were required to hold the targeted position for a time that was adjusted to change the task difficulty.ResultsWe demonstrated that three individuals with complete hand paralysis due to spinal cord injury (SCI) were able to maintain brain-control of closing and opening a virtual hand with an average of 63 % success which was significantly above the average chance rate of 19 %. This level of performance was achieved without pre-training and less than 4 min of calibration. In addition, successful grasp targets were reached in 1.96 ± 0.15 s. Subjects performed 200 brain-controlled trials in approximately 30 min excluding breaks. Two of the three participants showed a significant improvement in SMR indicating that they had learned to change their brain activity within a single session of NF.ConclusionsThis study demonstrated the utility of a MEG-based BCI system to provide realistic, efficient, and focused NF to individuals with paralysis with the goal of using NF to induce neuroplasticity.

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“…For example, prolonged video-MEG/EEG increase the probabilities to record and identify seizures [51]. Movement compensation [26,52] and the projection of recorded data to a standard virtual MEG helmet [53] enable the correction of (limited) patient movement during a seizure and increases the percentage of usable MEG recordings. Analytically, the application of STFT [27,28,31] for identification of seizure onsets, and the use of distributed source localization approaches [32,34], especially frequency-based methods [31], seem to improve the localization accuracy in comparison to ECD approaches.…”

Section: Discussionmentioning

confidence: 99%

Interictal and Ictal MEG in presurgical evaluation for epilepsy surgery

Stefan

Rampp

2020

Acta Epileptologica

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Although presurgical evaluation of patients with pharamacoresistent focal epilepsies provides essential information for successful epilepsy surgery, there is still a need for further improvement. Developments of noninvasive electrophysiological recording and analysis techniques offer additional information based on interictal and ictal epileptic activities. In this review, we provide an overview on the application of ictal magnetoencephalography (MEG). The results of a literature research for published interictal/ictal MEG findings and experiences with own cases are demonstrated and discussed. Ictal MEG may provide added value in comparison to interictal recordings. The results may be more focal and closer to the invasively determined seizure onset zone. In some patients without clear interictal findings, ictal MEG could provide correct localization. Novel recording and analysis techniques facilitate ictal recordings. However, extended recording durations, movement and artifacts still represent practical limitations. Ictal MEG may provide added value regarding the localization of the seizure onset zone but depends on the selection of patients and the application of optimal analysis techniques.

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Head movement compensation in real-time magnetoencephalographic recordings

Cited by 9 publications

References 29 publications

Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: a feasibility pilot

Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: a feasibility pilot

MEG-based neurofeedback for hand rehabilitation

Interictal and Ictal MEG in presurgical evaluation for epilepsy surgery

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