2020
DOI: 10.1038/s41572-020-00224-3
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Abstract: Most head and neck cancers are derived from the mucosal epithelium in the oral cavity, pharynx and larynx and are known collectively as head and neck squamous cell carcinoma (HNSCC). Oral cavity and larynx cancers are generally associated with tobacco consumption, alcohol abuse or both, whereas pharynx cancers are increasingly attributed to infection with human papillomavirus (HPV), primarily HPV-16. Thus, HNSCC can be separated into HPV-negative and HPV-positive HNSCC. Despite evidence of histological progres… Show more

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Cited by 1,737 publications
(1,441 citation statements)
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References 242 publications
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“…To obtain further insight into the CDC42 expression involved in signaling pathways in HCC, GSEA was performed. GSEA showed that CDC42 expression was positively associated with the Wnt signaling pathway (Figure 11 a- Immunotherapy with immune checkpoint inhibitors is a promising approach for cancer treatment [34], and it has been used to treat various cancers, including lung, liver, and head and neck cancers [35][36][37]. Abnormal immune checkpoint marker expression is a risk factor for many diseases [38].…”
Section: Cdc42 Positively Associated With Wnt Signaling Pathwaymentioning
confidence: 99%
“…To obtain further insight into the CDC42 expression involved in signaling pathways in HCC, GSEA was performed. GSEA showed that CDC42 expression was positively associated with the Wnt signaling pathway (Figure 11 a- Immunotherapy with immune checkpoint inhibitors is a promising approach for cancer treatment [34], and it has been used to treat various cancers, including lung, liver, and head and neck cancers [35][36][37]. Abnormal immune checkpoint marker expression is a risk factor for many diseases [38].…”
Section: Cdc42 Positively Associated With Wnt Signaling Pathwaymentioning
confidence: 99%
“…However, because of the treatment sensitivity of HPV-positive oropharyngeal carcinoma, appropriately reducing the treatment intensity would be an ideal strategy [29]. Therefore, in recent years, studies on intensity reduction therapy for HPV-positive oropharyngeal carcinoma emerge one after another.…”
Section: Hpv-associate Disease May Not Receive Aggressive Chemoradiotmentioning
confidence: 99%
“…As described above, HPV status contributes less to conventional treatment. As we know, cancer derives through the accumulation of genetic and epigenetic alteration in genes involved in a variety of signaling pathways and precipitates the cancerassociated phenotypes [29,36].…”
Section: Egfr/pi3k/akt/mtor Pathway Aberrant Activation Frequently Ocmentioning
confidence: 99%
“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide (1). There are ~650,000 new cases of HNSCC diagnosed every year, with >350,000 associated deaths occurring in a year (2).…”
Section: Introductionmentioning
confidence: 99%