HbA1c and Aortic Calcification Index as Noninvasive Predictors of Pre-Existing Histopathological Damages in Living Donor Kidney Transplantation

Tanaka, Kosuke; Yamanaga, Shigeyoshi; Hidaka, Yoshiki; Nishida, Sho; Kinoshita, Kohei; Kaba, Akari; Ishizuka, Toshinori; Hamanoue, Satoshi; Okumura, Kenji; Kawabata, Chiaki; Toyoda, Mariko; Takeda, Asami; Miyata, Akira; Kashima, Masayuki; Yasuda, Hiroshi

doi:10.3390/jcm9103266

Cited by 2 publications

(3 citation statements)

References 55 publications

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“…Chronic histopathological findings were classified according to the banff classification as ci, ct, and ah 27 . Other than IFTA, the definition of chronicity change is the combination of those above (ci + ct ≥ 1 ∩ ah ≥ 1) as previously reported 28 , 29 .…”

Section: Methodsmentioning

confidence: 99%

“…This included chronicity change, which is a combination of interstitial fibrosis (ci), tubular atrophy (ct), and arteriolar hyalinosis (ah) of Banff scores 27 (ci + ct ≥ 1 ∩ ah ≥ 1), which was related to suboptimal compensatory hypertrophy irrespective of donor age 28 . This chronicity change would have a long-term impact on the recipient as well 29 .…”

Section: Introductionmentioning

confidence: 99%

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Water intake, baseline biopsy, and graft function after living donor kidney transplantation

Yamanaga,

Hidaka,

Kawabata

et al. 2024

Sci Rep

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Increased water intake is recommended for kidney transplant recipients; however, its efficacy remains controversial. We hypothesized that pre-existing histological findings of the allograft might modulate the impact of water intake. We retrospectively analyzed 167 adults with living-donor kidney transplants (April 2011–May 2020; median observation period, 77 months) whose baseline biopsy data were available. We compared the chronic-change group (n = 38) with the control group (n = 129) to assess the impact of self-reported daily water intake on the estimated glomerular filtration rate (eGFR). The range distribution of water intake was as follows: − 1000 ml (n = 4), 1000–1500 ml (n = 23), 1500–2000 ml (n = 64), 2000–2500 ml (n = 57), 2500–3000 ml (n = 16), and 3000 − ml (n = 3). Donor age was significantly higher in the chronic-change group. In the control group, the ΔeGFR/year increase was correlated with water intake. However, the increase in the water intake of the chronic-change group significantly decreased ΔeGFR/year (1000–1500 ml: + 1.95 ml/min/1.73 m2 and > 2000 ml: − 1.92 ml/min/1.73 m2, p = 0.014). This study suggested a potential influence of increased water intake on recipients with marginal grafts in living donor kidney transplantation.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Water intake, baseline biopsy, and graft function after living donor kidney transplantation

Yamanaga,

Hidaka,

Kawabata

et al. 2024

Sci Rep

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“…In donors, a seemingly healthy population, abdominal aortic calcification has been less researched. However, a study has claimed that aortic calcification might be an independent risk factor for pre-existing histopathological injuries in the allograft [19].…”

Section: Introductionmentioning

confidence: 99%

Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors

Ribeiro

Almeida

Malheiro

et al. 2023

JCM

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Background: Vascular calcification is an ever-more-common finding in protocoled pre-transplant imaging in living kidney donors. We intended to explore whether a connection could be found between the Agatston calcification score, prior to kidney donation, and post-donation renal function. Methods: This is a retrospective analysis of 156 living kidney donors who underwent living donor nephrectomy between January 2010 and December 2016. We quantified the total calcification score (TCaScore) by calculating the Agatston score for each vessel, abdominal aorta, common iliac, and renal arteries. Donors were placed into two different groups based on their TCaScore: <100 TCaScore group and ≥100 TCaScore group. The relationship between TCaScore, 1-year eGFR, proteinuria, and risk of 1 measurement of decreased renal function (eGFR < 60 mL/min/1.73 m2) over 5 years of follow-up was investigated. Results: The ≥100 TCaScore group consisted of 29 (19%) donors, with a median (interquartile range) calcification score of 164 (117–358). This group was significantly older, 56.7 ± 6.9 vs. 45.5 ± 10.6 (p < 0.001), had a higher average BMI (p < 0.019), and had a lower preoperative eGFR (p < 0.014). The 1-year eGFR was similarly diminished, 69.9 ± 15.7 vs. 76.3 ± 15.5 (p < 0.048), while also having an increased risk of decreased renal function during the follow-up, 22% vs. 48% (p < 0.007). Conclusions: Our study, through univariate analyses, found a relationship between a TCaScore > 100, lower 1-year eGFR, and decreased renal function in 5 years. However, a higher-than-expected vascular calcification should not be an excluding factor in donors, although they may require closer monitoring during follow-up.

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HbA1c and Aortic Calcification Index as Noninvasive Predictors of Pre-Existing Histopathological Damages in Living Donor Kidney Transplantation

Cited by 2 publications

References 55 publications

Water intake, baseline biopsy, and graft function after living donor kidney transplantation

Water intake, baseline biopsy, and graft function after living donor kidney transplantation

Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors

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