HbA_1c combined with glycated albumin or 1,5‐anhydroglucitol improves the efficiency of diabetes screening in a Chinese population

Abstract

Aims: This study aimed to evaluate the ability of HbA 1c combined with glycated albumin (GA) or 1,5-anhydroglucitol (1,5-AG) to detect diabetes in residents of Jiangsu, China. Methods:The oral glucose tolerance test (OGTT) was performed on 2184 people in Jiangsu. HbA 1c , GA, 1,5-AG and other serum biochemical parameters were measured. Receiver operating characteristic curves were plotted to determine the optimal thresholds of HbA 1c , GA and 1,5-AG according to the Youden index. Results:(1) The optimal thresholds of HbA 1c , GA and 1,5-AG for the screening of diabetes were ≥45 mmol/mol (6.3%), ≥13.0% and ≤23.0 μg/ml, respectively. (2)The sensitivities of HbA 1c combined with GA and 1,5-AG were both 85%, higher than that of HbA 1c (70%, p < 0.001). Conclusions:This study is suitable for cases where plasma glucose is unavailable. Among the residents of Jiangsu, HbA 1c combined with GA or 1,5-AG can improve the sensitivity of diabetes screening, reduce the miss rate and save the use of OGTT. GA and 1,5-AG are superior in individuals with mild glucose metabolism disorder. GA enhances the detection of diabetes in the nonobese, and 1,5-AG enhances the detection in those with hyperuricaemia.

Optimal 1,5-anhydroglucitol cut-off points for diagnosing diabetes based on prevalence of retinopathy in Chinese population

“…As can be seen in Table 2, the sensitivity for diagnosing diabetes increased slightly as the level of 1,5-AG increased, accompanied by sharp decreasing speci city. Notably, our previous study [20] showed that 23 µg/mL was a reasonable point for 1,5-AG to screen for diabetes. In this study, the sensitivity and speci city were 81.5% and 67.7%, respectively, at the point of 23.55 µg/mL.…”

The progress of clinical research on the detection of 1,5-anhydroglucitol in diabetes and its complications

“…J Qian et al. ( 42 ) conducted a study of 2,184 people in Jiangsu Province which showed that the optimal threshold for 1,5-AG screening for diabetes was ≤23.0 μg/mL, and the sensitivity of HbA1c combined with 1,5-AG was 85% higher than HbA1c (70%). H Su et al.…”

“…Combining 1,5-AG with HbA1c, FPG, and GA to screen for diabetes with high sensitivity and specificity is more conducive to clinical application. J Qian et al (42) conducted a study of 2,184 people in Jiangsu Province which showed that the optimal threshold for 1,5-AG screening for diabetes was ≤23.0 mg/mL, and the sensitivity of HbA1c combined with 1,5-AG was 85% higher than HbA1c (70%). H Su et al (43) discovered that the sensitivity of 1,5-AG combined with FPG screening for diabetes was 84.92% and the specificity was 91.45% higher than the GA combined with FPG (77.71% and 90.88%) or using the above-mentioned indicators alone.…”

An Efficient Electrochemical Biosensor to Determine 1,5-Anhydroglucitol with Persimmon-Tannin-Reduced Graphene Oxide-PtPd Nanocomposites

“…The normal concentration of 1,5-AG is approximately 12–40 μg/mL. However, serum 1,5-AG concentrations have been found to decrease in patients with DM [ 6 , 7 , 8 ]. Several methods have been explored to detect the level of serum 1,5-AG in a sensitive and accurate way.…”