Hazard-rate analysis in state I malignant melanoma

EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanoma

“…(We were unable to address the possibility that the patient's prior vulvar tumor was itself a misdiagnosed CCS because that specimen originated at an outside institution and was not available for study.) Case 11 therefore demonstrates that although metastatic involvement of the GI tract by melanoma is a well-established pattern of disease, and although MM can present after disease-free intervals of a decade or more [43][44][45], a GI tumor with the morphologic and immunohistochemical features of MM in a patient with a history of melanoma may nonetheless represent an independent CCS. However, the cases in our study suggest that this is a rare event.…”

“…As it is well established that melanoma can initially present as a metastasis even in the absence of a recognized primary cutaneous tumor [41,42], and that metastasis from a known cutaneous melanoma can develop after a prolonged disease-free interval [43][44][45], we performed a detailed review of the patients' medical records (including, where appropriate, questioning the patients about their history of melanoma) to assure that the clinical history of the study cases was accurate.…”