2012
DOI: 10.1038/ajg.2011.448
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Abstract: This population-based inception cohort has shown that the recent reduction in surgical rates was independently associated with increased and earlier AZA use.

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Cited by 195 publications
(169 citation statements)
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“…Our study echoed the observed trends that more IM but less 5-ASA products are currently used in CD management [18][19][20][21][22] . Immunomodulators are effective maintenance medications and azathioprine has been shown to modestly lower the risk of surgery [23][24][25] .…”
Section: Discussionsupporting
confidence: 74%
See 1 more Smart Citation
“…Our study echoed the observed trends that more IM but less 5-ASA products are currently used in CD management [18][19][20][21][22] . Immunomodulators are effective maintenance medications and azathioprine has been shown to modestly lower the risk of surgery [23][24][25] .…”
Section: Discussionsupporting
confidence: 74%
“…The recent shift in medical management of Crohn's disease has decreased the cumulative surgical rate of CD patients [15][16][17][18][19][20] . Our study echoed the observed trends that more IM but less 5-ASA products are currently used in CD management [18][19][20][21][22] .…”
Section: Discussionmentioning
confidence: 99%
“…Given the weak evidence to support the use of 5-ASA, this favourable judgement of 5-ASA response may rather reflect a benign natural course of CD than the intrinsic drug efficacy. 5,18 Looking at this striking gap between scientific evidence and clinical practice, other factors than only perceived previous treatment response may be related to the broad use of 5-ASA for CD treatment. The first may be that 5-ASA are generally perceived as safe and side effects are seldom reported.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, the analyses from our cohort and others demonstrate that side effects are not a limiting factor in prescribing 5-ASA products in CD patients. 18,19 A second factor potentially associated with the broad use of 5-ASA might be the physicians's intention to perform a chemoprevention of colonic dysplasia in patients with long-standing disease. 20 We expected the prescription rate of 5-ASA to increase over time, at least after a disease duration of more than 10 years.…”
Section: Discussionmentioning
confidence: 99%
“…It often develops at an early age and can affect the entire gastrointestinal tract from the oral cavity to the anus. It is also known to frequently require intestinal resection due to the development of intestinal complications such as stenosis and fistula through repeated relapses or recurrences [1][2][3][4]. Although there are some reports of the long-term course of patients with this disease, there are very few reports related to their survival and cause of death; moreover, most previous reports are derived from population-based cohort studies, and there are very few, long-term, hospital-based, cohort studies with a long duration of follow-up and a large sample size [5][6][7][8][9][10][11][12][13][14].…”
Section: Introductionmentioning
confidence: 99%