Harvey Cushing and Medulloblastoma

Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients

“…[27] Cushing[27] operated on 61 medulloblastomas by 1930 and it was clear that surgery alone did not impact survival. He was only cautiously optimistic about a posterior fossa medulloblastoma at the end of his career.…”

“…Cushing[27] in 1930 has an operative mortality of 32% in his experience with 61 cases of medulloblastoma. On comparative analysis of our case series between 1985 and 2000 and 2000-2010, the surgical mortality has significantly reduced from 8% to 2%.…”

Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients

“…[27] Cushing[27] operated on 61 medulloblastomas by 1930 and it was clear that surgery alone did not impact survival. He was only cautiously optimistic about a posterior fossa medulloblastoma at the end of his career.…”

“…Cushing[27] in 1930 has an operative mortality of 32% in his experience with 61 cases of medulloblastoma. On comparative analysis of our case series between 1985 and 2000 and 2000-2010, the surgical mortality has significantly reduced from 8% to 2%.…”

Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas

“…The histogenesis of embryonal brain tumors has been controversial since the time of Bailey and Cushing. 3,21 Young age of onset, primitive histological features, highly malignant behavior, and multilineage differentiation patterns suggest that these tumors originate from stem cells or early progenitor cells. The discovery of tumor-initiating cells in specimens from many brain tumors, including medulloblastomas, also supports this suggestion.…”

Pathology of Medulloblastoma: Morphologic Features and Molecular Classification

“…The origin of the term "medulloblastoma" and how its usage has evolved over time is important in understanding the histopathology and current classification of the tumor. Medulloblastoma was first characterized by Cushing and Bailey in 1924 as a rapidly growing cerebellar tumor with a relatively poor prognosis [2,3]. It was initially classified as a type of glioma and designated "spongioblastoma cerebelli" but was later changed to "medulloblastoma" to avoid confusion with other gliomas having a similar descriptive name [4].…”

Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients

“…[27] Cushing[27] operated on 61 medulloblastomas by 1930 and it was clear that surgery alone did not impact survival. He was only cautiously optimistic about a posterior fossa medulloblastoma at the end of his career.…”

“…Cushing[27] in 1930 has an operative mortality of 32% in his experience with 61 cases of medulloblastoma. On comparative analysis of our case series between 1985 and 2000 and 2000-2010, the surgical mortality has significantly reduced from 8% to 2%.…”

Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas

“…The histogenesis of embryonal brain tumors has been controversial since the time of Bailey and Cushing. 3,21 Young age of onset, primitive histological features, highly malignant behavior, and multilineage differentiation patterns suggest that these tumors originate from stem cells or early progenitor cells. The discovery of tumor-initiating cells in specimens from many brain tumors, including medulloblastomas, also supports this suggestion.…”

Pathology of Medulloblastoma: Morphologic Features and Molecular Classification

“…The origin of the term "medulloblastoma" and how its usage has evolved over time is important in understanding the histopathology and current classification of the tumor. Medulloblastoma was first characterized by Cushing and Bailey in 1924 as a rapidly growing cerebellar tumor with a relatively poor prognosis [2,3]. It was initially classified as a type of glioma and designated "spongioblastoma cerebelli" but was later changed to "medulloblastoma" to avoid confusion with other gliomas having a similar descriptive name [4].…”

Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients

“…[27] Cushing[27] operated on 61 medulloblastomas by 1930 and it was clear that surgery alone did not impact survival. He was only cautiously optimistic about a posterior fossa medulloblastoma at the end of his career.…”

“…Cushing[27] in 1930 has an operative mortality of 32% in his experience with 61 cases of medulloblastoma. On comparative analysis of our case series between 1985 and 2000 and 2000-2010, the surgical mortality has significantly reduced from 8% to 2%.…”

Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas

“…The histogenesis of embryonal brain tumors has been controversial since the time of Bailey and Cushing. 3,21 Young age of onset, primitive histological features, highly malignant behavior, and multilineage differentiation patterns suggest that these tumors originate from stem cells or early progenitor cells. The discovery of tumor-initiating cells in specimens from many brain tumors, including medulloblastomas, also supports this suggestion.…”

Pathology of Medulloblastoma: Morphologic Features and Molecular Classification

“…The origin of the term "medulloblastoma" and how its usage has evolved over time is important in understanding the histopathology and current classification of the tumor. Medulloblastoma was first characterized by Cushing and Bailey in 1924 as a rapidly growing cerebellar tumor with a relatively poor prognosis [2,3]. It was initially classified as a type of glioma and designated "spongioblastoma cerebelli" but was later changed to "medulloblastoma" to avoid confusion with other gliomas having a similar descriptive name [4].…”